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Intervention for the treatment of diabetes
Advantages and disadvantages of using stem cells for therapeutic purposes
Advantages and disadvantages of using stem cells for therapeutic purposes
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Recommended: Intervention for the treatment of diabetes
Type one diabetes is a disease that is affecting millions of people worldwide. Studies have shown by the year 2010 the number of people suffering from diabetes exceed 350 million (Bethesda, 2013). This places a huge deficit in America’s health and is a burden to society. It is crucial to find a cure before millions more people become diagnosed with diabetes.
A therapeutic method has been tested to treat type one diabetes through stem cell therapy. Research has shown promise, but also risks along the way. May this be a medical break through or a risky trade for the cure? Studies have shown progress through experiments in mice, concluding that embryonic stem cells can be cultured into a cell that makes and secretes insulin (Serup, 2001). In many cases over the counter drugs do not provide enough stability or control of the glucose in the blood (Serup, 2001). Through the manipulation of cells such as stem cell embryotic, germinal, and adult stem cells have shown evidence for a possible cure.
Embryotic secretion takes place in the embryotic cells that have been cultured and donated. Stem cell therapy is used for the regeneration and reproduction of new cells in the pancreases. Ideally, stem cells should be able to multiply and reproduce themselves. There are other options regarding stem cell therapy, such as cloning cells, which may be beneficial as well. The reason why is because it minimizes the percentage of rejection, but its also risky on the count of a surgical transfusion that may have complications and can be very expensive (Park EL AL. 2008).
The use for stem cells in type one diabetes involves the insertions of the beta cell. The beta cells are located in the pancreas, which secretes insulin. Insulin is a protein that ge...
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...ure, 132(2,25) 183-184.
Eggleson, K. E. (2012). Stem Cell-Based Therapies: Promises, Obstacles, Discordance, and the Agora. Perspectives in Biology and Medicine, 55(1), 1-25.
Serup, P. S. (2001) Islet and stem cell transplantation for treating diabetes. Development of biology, 322(6). 29-32
Han, J. H., and Sidhu, K. S. (2011). Embryonic stem cell extracts: use in differentiation and reprogramming. Regenerative Medicine. 6(2), 215.
Rother, K. R, and Harlan, D. H. (2004) Challenges facing islet transplantation for the treatment of type 1 diabetes mellitus. Journal of Clinical Investigation 114(7), 877-883.
Bonner‐Weir, S. B-W., and Sharma, A. S. (2002) Pancreatic stem cells. The Journal of Pathology 197(4), 519-526.
Bethesda, B. National Institutes of Health, U.S. Department of Health and Human Services, [Online]. Available: http://www.nih.gov [02/22/14]
The beta cells affect a person’s glucose regulations within the blood. This is because the beta cells are in charge of sending insulin arou...
The wide range of prospective uses for stem cells could greatly improve the health and wellbeing of many people. In stem cell treatments, undifferentiated cells are programmed to form specific cells, which can then be transplanted to the afflicted area. Stems cells can possibly treat afflictions including “Alzheimer’s diseases, spinal cord injury, stroke, burns, heart disease, diabetes, osteoarthritis, and rheumatoid arthritis” (“Stem Cell Basics”). Another important use is in drug testing. Drugs can be tested on stem cells that develop into the target tissue before using it on human test subjects, which improves safety. Finally, transplantation of organs created from stem cells could eliminate the need for human...
Thesis: Diabetes type 1 is different from type 2 and if given the wrong treatment it could lead to devastating consequences.
6. Claiborn K, Stoffers D. Toward a cell-based cure for diabetes: advances in production and transplant of beta cells. The Mount Sinai Journal Of Medicine, New York [serial online]. August 2008;75(4):362-371. Available from: MEDLINE with Full Text, Ipswich, MA. Accessed November 19, 2013.
For example, the letter sent to President Bush says that "insulin-secreting cells have normalized blood glucose in diabetic mice." These experiments were done with ADULT stem cells from mice, NOT embryonic stem cells. In fact, there are as yet no reports of anyone being able to produce insulin-secreting cells from human embryonic stem cells, but human ADULT stem cells that secrete insulin HAVE been isolated.
The article, “Pancreas Transplant: A Cure for Diabetes?” written by Eli A. Friedman, M.D., explores the possibility of a cure for type 1 diabetes and the implications involving this experimental procedure. The article discusses current procedures and treatments that are commonly used to control type 1 diabetes and highlights provisional treatments that evolved into pancreatic transplant surgery.
... U.S. Department of Health and Human Services Public Health Service, National Institutes of Health, National Institute of
Stem cells are pluripotent cells of the body which are “undifferentiated.” This means that stem cells can ultimately give rise to any type of body tissue. Thus stem cells have the potential to cure a vast number of diseases and physical ailments including Parkinson’s, diabetes, spinal cord injury, and heart disease. Consequently, stem cell research and the development of associated medical applications are of great interest to the scientific and medical community. The area of stem cell research involving human embryonic stem cells is of particular interest in that embryonic stem cells are derived from week-old blastocysts developed from in vitro fertilized eggs. As opposed to adult stem cells, which must undergo a complicated process of de-differen...
Islet transplantation is a rapidly evolving technology with advantages and disadvantages, that’s why it should be performed only within the setting of controlled research studies.
Page-Reeves, J., Niforatos, J., Mishra, S., Regino, L., Gingrich, A., & Bulten, J. (2011). Health
“Stem Cells: The Future of Medicine.” Medschool.umaryland.edu. University of Maryland School of Medicine Web 14 Nov 2013
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United States. (2011). Type 1 Diabetes Research: Real Progress and Real Hope for a Cure. Hearing Before the Committee on Homeland Security and Government Affairs, United States Senate, of the One Hundred Eleventh Congress, First Session, June 24, 2009. Washington, DC: Washington: U.S. G.P.O., 2011
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