Pancreatic Transplantation

1945 Words4 Pages

Pancreatic transplantation is an established therapy for patients with type 1 DM. Discuss the evidence, the advantages and disadvantages and the outcomes of pancreatic transplantation. What other developments are they’re relating to beta-cell transplantation and what are the difficulties?

Introduction

Pancreatic transplantation is a surgical procedure in which a diseased pancreas is replaced with a healthy one in type 1 diabetic patients enabling the production of insulin, which they can’t produce endogenously. Pancreas transplant is commonly combined with kidney transplant which was proved to reduce the complications of type 1 DM. Pancreatic transplant is the patients’ key for insulin independence, which in turn, leads to a better quality of life with less diabetes complications, it showed successful outcomes of 76% with well functioning Pancreas a year after. The procedure has been known to be quite popular (1), it had been estimated that over 300 people in the UK are on the waiting list for the transplant (1). Ever since the success of the early pancreas transplant, people are looking forward performing that operation to solve their problems with diabetes.

The first pancreatic transplant was carried out in 1966, at the University of Minnesota Medical Center, by a team, Dr. Kelly, Dr. Lillehei, Dr. Merkel, Dr. Idezuki Y, & Dr. Goetz, who transplanted a kidney and duodenum as well as a pancreas into a 28-year-old woman's body, right after the transplant, her blood sugar levels decreased, and unfortunately she died three months later because of pulmonary embolism. In 1979, in the same center, David E.R. Sutherland, MD, PhD, performed the world's first successful partial pancreas transplant. The University of Minnesota Medical...

... middle of paper ...

...and cancers. (----------- )

Islet transplantation is a rapidly evolving technology with advantages and disadvantages, that’s why it should be performed only within the setting of controlled research studies.
Conclusion: -
Pancreatic transplant is the patients’ key for insulin independence that leads to a better quality of life, with less diabetic complications. Pancreatic islet cell transplantation is another intervention for life long management for uncontrolled and complicated DM types I especially the hypos. The Indications and contraindications for Pancreas Transplantation and islet cell transplant depend on which type of transplant the patient need. The outcomes of Pancreatic transplant and Islet cell transplantation are promising. Further developments in this field are coming hoping to find effective and efficient solution for DM type1 and its complications.

Open Document