Vancomycin Research Paper

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Vancomycin
Vancomycin can be classified to the Glycopeptide antibiotic group.
• Vancomycin was first discoverd by Eli Lilly, from a soil sample which is collected from the jungles of Borneo. It is a naturally obtained antibiotic produced by the soil bacterium Actinobacteria species Amycolatopsis orientalis
• The one advantage that was apparent is that staphylococci did not develop very strong resistance inspite of introducing it several times in culture media with vancomycin
• The drug fast tracked in achieving Fda approval in 1958, which is very quick for any drug. Staph had developed a significant resistance towards penicillin based anyibiotic. This helped Vancomycin to get approval in drug market in a short span.
• found in soils obtained from Borneo and India
• The compound derived its name from VANQUISH
• Drug of last resort.

Mechanism of Action
• Constrains bacterial cell wall synthesis at a site different than beta-lactam. The Beta lactams attack the enzyme , where as Vancomycin attacks the substrate itself.
• Inhibits synthesis and assembly of peptidoglycan polymers. pept...

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