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Type 1 diabetes research paper
Type 1 diabetes research paper
Type 1 diabetes research paper
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According to Dr. Kishore who wrote the “Diabetes Mellitus” article in 2014 for the Merck Manual, Diabetes Mellitus is commonly known as Diabetes, and it is a chronic condition in which blood sugar, or glucose, levels are abnormally elevated because adequate insulin is not produced by the body to meet required needs.
Insulin is a hormone released from the pancreas which controls the amount of glucose in the blood (Kishore, 2014). The pancreas is stimulated by glucose in the bloodstream in order to produce insulin. Insulin is needed to help transport glucose from the blood into the cells of the body. The glucose is then transformed into energy for the body once inside the cells. The glucose levels in the blood vary throughout the day and is
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Pre-diabetes is a condition in which blood glucose levels are higher than normal but aren’t high enough to be considered diabetes (Kishore, 2014). Type 1 diabetes is formally known as insulin-dependent diabetes or juvenile diabetes. In type 1 diabetes, the body’s immune system acts against the insulin producing cells of the pancreas, and over 90% of those cells are destroyed permanently (Kishore, 2014). The pancreas is left with no choice but to produce a very small amount of insulin or none at all. For this reason, sugar is not able to reach into the body’s cells to be used for energy (Cleveland Clinic, 2013). Of all the people living with diabetes, only about ten percent live with Type 1 diabetes (Kishore, 2014). Type 2 diabetes is formally known as non-insulin dependent diabetes or adult-onset diabetes. In this type, the pancreas sometimes produce insulin at higher levels than normal. Unfortunately, the body then develops a resistance against the effects of insulin. At this point, there is not enough insulin to meet the needs of the body (Kishore, 2014). Type 2 diabetes usually begins in people older than the age of …show more content…
“Nine out of ten people with diabetes have type 2” (Cleveland Clinic, 2013). It mostly affected said older adults, but it has recently become more common in young children and adolescents than before. “About 27% of people older than 65 have type 2 diabetes,” Dr. Kishore stated. Type diabetes commonly runs within families, and they are more common in certain races more so than others. Blacks, Asian Americans, Hispanics, and American Indians who reside in the United States are at an extremely higher risk of acquiring type 2 diabetes than whites (Kishore, 2014). One factor that greatly contributes to the risk of developing type 2 diabetes is obesity. Amongst the people with type 2 diabetes in the country, about 80-90% are obese or overweight. Obesity may be considered the greatest risk factor for type 2 diabetes. Insulin resistance is caused by obesity. Therefore, people who are extremely overweight or obese need huge amounts of insulin to maintain blood glucose levels in good standing (Kishore,
Diabetes Mellitus is defined as “a disease in which too little or no insulin is produced or insulin is produced but cannot be used normally resulting in high levels of sugar in the blood” (merriam-webster.com, 2016). Insulin is a hormone which regulates glucose, or blood sugar, ensuring that it is used as energy by the body’s cells. If the insulin levels are irregular, the glucose remains in the blood
According WebMD 2014. Diabetes mellitus (or diabetes) is a chronic, lifelong condition that affects your body's ability to use the energy found in food. There are three major types of diabetes. Type 1 diabetes mellitus, type 2 diabetes mellitus and gestational diabetes. It is a hormonal disorder of the pancreas either decrease in insulin level also known as hypoinsulinism or increase in insulin level also known as hyperinsulinism. Lowered amounts, insufficient of, or ineffective use of insulin leads to the disorder of diabetes mellitus. It is common chronic disease requiring lifelong behavioral and lifestyle changes. According to Peakman (2012). The development of type 1 diabetes mellitus is a genetic and an autoimmune process that results in destruction of the beta cells of the pancreas, leading to absolute insulin deficiency. There is usually a pre-diabetic phase where autoimmunity has already developed but with no clinically apparent insulin dependency. Insulin autoantibodies can be detected in genetically predisposed individuals as early as 6-12 months of age. In persons genetically susceptible to type 1 diabetes, a triggering event, possibly a viral infection the leads to production of autoantibodies that kill the beta cells and results in decline and a lack of insulin secretion. According to Wherrett. It is caused by impaired insulin secretion and insulin resistance and has a gradual onset. Those with type 2 diabetes may eventually need insulin treatment. Gestational diabetes mellitus is glucose intolerance during pregnancy in a woman not previously diagnosed with diabetes, this may occur if placental hormones counteract insulin, causing insulin intolerance. Complications in diabetes mellitus includes: Hypoglycemia it is ca...
Our body obtains the energy by digesting the carbohydrates into glucose. Volumes of glucose are required by the body to create ATP. ATP is short for 'Adenosine Triphosphate ' and is an energy carrier. When we consume too many carbohydrates our body produces a lot of glucose and as a result blood glucose levels rise and sometimes they may rise over the normal range of blood glucose concentration. To bring it back within the healthy range, the homeostatic system of blood glucose regulation is used. The blood flows through the pancreas where the beta cells, receptors, detect the high blood glucose level. To counteract this stimuli beta cells alert the control centre, which are also the beta cells located in the islets of Langerhans in the pancreas. The secretion of insulin has to be done quickly but can only be carried out when insulin gene is switched on. Turning on the insulin gene switch can take 30 minutes to an hour therefore, the production of insulin by beta cells are done in advance and are packaged in vesicles right until blood glucose rises. Glucose comes into the beta cell to trigger the vesicle that contains the insulin to move towards the plasma membrane and fuse. This releases the insulin into the bloodstream where they are distributed throughout the body and only affect specific target cells. The receptor, a protein, on the target cell’s plasma membrane recognises and connects
Insulin: a hormone made by the pancreas that allows your body to use sugar (glucose) from carbohydrates in the food that you eat for energy or to store glucose for future use. Insulin helps keeps your blood sugar level from getting too high (hyperglycemia) or too low (hypoglycemia). Before insulin Diabetes mellitus was a chronic disease that affected thousands of people in Canada and beyond. In the first half of the 20th century, medical professionals understood that diabetes mellitus involved the body’s inability to metabolize food, especially carbohydrates. “Insuline” was already in development as many medical professionals like Joseph Freiherr and Oscar Minkowski, isolated its properties before Banting had his ideas. As well Ancient Greek
Diabetes Mellitus (Type 2 diabetes/adult onset diabetes) is an epidemic in American Indian and Alaska Natives communities.7 AI/AN have the highest morbidity and mortality rates in the United States.7 American Indian/Alaska Native adults are 2.3 more times likely to be diagnosed with Diabetes Mellitus than non-Hispanic Whites.7 More importantly, AI/AN adolescent ages 10-14 are 9 times likely to be diagnosed with Diabetes Mellitus than non-Hispanic Whites.7 Type 2 diabetes is high blood glucose levels due to lack of insulin and/or inability to use it efficiently.8 Type 2 diabetes usually affects older adults; 8 however, the incident rate is rising quicker amongst AI/AN youth than non-Hispanic Whites.7 This is foreshadowing of earlier serious complications that will be effecting the AI/AN communitie...
16Scientist have found trends in ethnic groups and ages begin to occur in today’s day and age. Type 2 diabetes has been found to be more
Diabetes is a disease in which a person’s body in unable to make or utilize insulin properly which affects blood sugar levels. Insulin is a hormone that is produced in the pancreas, which helps to regulate glucose (sugar) levels, break down carbohydrates and fats, and is essential to produce the body’s energy. The CDC (2013) offers reliable insight, summarized here, into the different types of diabetes, some causes, and health complications that may arise from the disease.
Insulin is a hormone produced by the B cells in the islets of Langerhans of the pancreas. Under normal conditions, insulin is continuously released into the bloodstream in small pulsatile increments (a basal rate), with increased release (bolus) when food is ingested. The activity of released insulin lowers blood glucose and facilitates a stable, normal glucose range of approximately 70 to 120 mg/dl. The average amount of insulin secreted daily by and adult is approx. 40 to 50 U, or 0.6 U/kg of body weight.
Diabetes is a disease that affects the body’s ability to produce or respond to insulin, a hormone that allows blood glucose (blood sugar) to enter the cells of the body and be used for energy. Diabetes falls into two main categories: type 1, or juvenile diabetes, which usually occurs during childhood or adolescence, and type 2, or adult-onset diabetes, the most common form of the disease, usually occurring after age 40. Type 1 results from the body’s immune system attacking the insulin-producing cells in the pancreas. The onset of juvenile diabetes is much higher in the winter than in the summer. This association has been repeatedly confirmed in diabetes research. Type 2 is characterized by “insulin resistance,” or an inability of the cells to use insulin, sometimes accompanied by a deficiency in insulin production. There is also sometimes a third type of diabetes considered. It is gestational diabetes, which occurs when the body is not able to properly use insulin during pregnancy. Type 2 diabetes encompasses nine out of 10 diabetic cases. Diabetes is the fifth-deadliest disease in the United States, and it has no cure. The total annual economic cost of diabetes in 2002 was estimated to be $132 billion, or one out of every 10 health care dollars spent in the United States. Diabetes risk factors can fall into three major categories: family history, obesity, and impaired glucose tolerance. Minority groups and elderly are at the greatest risk of developing diabetes.
The prevalence of diabetes according to the CDC is 26 million Americans currently diagnosed with diabetes, 79 million with pre-diabetes, and 7 million unaware they have diabetes.1 Diabetes is currently more prevalent in the western countries due to physical inactivity and obesity, but as more Eastern countries develop the western lifestyle it becomes an increasing worldwide epidemic.1 The risk for developing type 2 diabetes increases with age (especially after age 40), but is increasing most rapidly in the adolescent and young generation.1 It is therefore critical that education as well as drug therapies are implemented to decrease the rising prevalence of this illness.
Diabetes has been a growing problem for many years among adults in the United States. There is a growing number of Hispanic being diagnosed with type 2 diabetes. Hispanic people are at a higher risk of developing type 2 diabetes than non-Hispanic people (American 2013). Type 2 diabetes, in Hispanic should be addressed because the disease can be prevented. This disease can lead to number of medical problems if it goes untreated or if significant life style changes aren’t made. Simple changes can be made to prevent getting this disease. Such as, adding more fresh fruits and vegetables, drinking more water and limiting fast food intake (American 2013). Losing excess weight is an excellent way to reduce developing type 2 diabetes. A good way to do this is getting the whole family involved in biking or walking. If this issue isn’t addressed more people will develop the disease, that is preventable. Another result of this would be that the government will have to budget more money towards healthcare.
Insulin is a hormone in the body that is critical in many of the body’s functions. Insulin is a hormone made up of a small polypeptide protein that is secreted by the pancreas it affects carbohydrate, protein, and fat metabolism. Your body breaks these nutrients down into sugar molecules, amino acid molecules, and lipid molecules. The body can also store and reassemble these molecules into more complex forms. Insulin causes the storage of these nutrients. After eating a meal blood sugars rise rapidly especially after eating carbohydrates, this signals the release of insulin. Insulin binds to insulin receptors on the outside of cells to open up channels for glucose to move into the cell for storage by the means of GLUT-4 inside the cell. With insulin resistance the pancreas has to work harder to make up for the insulin resistance but as the resistance gets worse the pancreas can not keep up and blood glucose levels stay elevated. A major way to prevent type II diabetes and high blood glucose is to improve a patient’s insulin sensitivity.
You may ask yourself, what is diabetes? Diabetes is usually a lifelong (chronic) disease in which there is a high level of sugar in the blood. To understand that though, you must first understand the job of insulin. Insulin is a hormone produced by the pancreas to control your blood sugar. When you eat, your body turns that food into a sugary substance called glucose. Now your pancreas is supposed to release insulin. However, if you have diabetes, that process doesn’t work, causing ...
Blood glucose levels are the measurement of glucose in an individual’s blood. This is important because glucose is the body’s main source of fuel and the brains only source of fuel. Without energy from glucose the cells would die. Glucose homeostasis is primarily controlled in the liver, muscle, and fat where it stored as glycogen. The pancreas is also a significant organ that deals with glucose. The pancreas helps regulate blood glucose levels. Alpha-islet and beta-islet pancreatic cells measure blood glucose levels and they also regulate hormone release. Alpha cells produce glucagon and beta cells produce insulin. The body releases insulin in response to elevated blood glucose levels to allow the glucose inside of cells and
“Diabetes mellitus (sometimes called "sugar diabetes") is a condition that occurs when the body can't use glucose (a type of sugar) normally. Glucose is the main source of energy for the body's cells. The levels of glucose in the blood are controlled by a hormone called insulin, which is made by the pancreas. Insulin helps glucose enter the cells” (Diabetes Mellitus).