Tuberculosis (TB), a deadly contagious disease is among the three major infectious killers that causes high mortality and morbidity, worldwide.1 Tuberculosis infects one-third of the world's population with an estimated 8.7 million new cases and 1.4 million deaths every year (WHO, 2012)2. Tuberculosis prevention has become more complex due to increased resistance against different antibiotics including rifampicin.3
TB is a socio-economic disaster that is occurring worldwide, especially in Asia and Africa.4 Pakistan is ranked 6th in terms of estimated number of the tuberculosis cases by World Health Organization (WHO) among high burden countries.5It is the second leading cause of adult death in impoverished communities of Pakistan.6
Mycobacterium tuberculosis (MTB) is the main causative organism which attacks the lungs but can also infect other organs of the body. M.tuberculosis is an intracellular pathogen that is highly adapted to human.7The bacterium spread primarily through aerosolized infectious particles generated from coughing and sneezing by individuals with pulmonary tuberculosis and less commonly via skin wounds 8. The most important factors influencing the current TB epidemic in resource poor setting are closely related to malnutrition, overcrowded living conditions and lack of access to free or affordable health care services.9
Early diagnosis of tuberculosis is essential in limiting the spread of mycobacterium tuberculosis infection due to primary route of infection in humans. Sputum smear microscopy has remained the corner stone of TB diagnosis in the global strategy to control the disease. 10 The global targets for TB control, adopted by World Health Assembly, are to cure 85% of the newly detected smear positive T...
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...istics of diagnostic accuracy of ELISA have been also reported in different studies. 22,23
As far as serology in extra-pulmonary tuberculosis is concerned, different studies regarding antibodies detection in Mycobacterium Tuberculosis have shown good results with high sensitivity and specificity.24
In a study for comparison of conventional method AFB smear with PCR technique for detection Tuberculosis conducted in Sudan at 2004 , showed microscopic sensitivity was 65% and the specificity was 90.5%,Whereas sensitivity of PCR was 88.5% and specificity was 98.6 %.They concluded that though PCR sensitivity was 13.1% higher than smear microscopy .25
In a recent study, the diagnostic role of XpertMTB/RIF demonstrated sensitivities of 98.2% and 72.5% with smear-positive and negative TB, respectively. The tests specificity was 99.2% in patients without Tuberculosis. 26
Paul Farmer designed several studies that he used to help create new TB treatment methods, including a study about a system called active case finding, which helps find TB cases more quickly. The previous system of tuberculosis case finding is known as passive case finding. Passive case finding is when tu...
One of the largest epidemic events in history, the Bubonic Plague had a devastating effect on European society. It is believed to have begun in China, and it reached European soil in 1347, when it struck Constantinople (Document 1). It was carried by infected fleas that spread the disease between humans and rats. A symptom of the plague was the development of large, dark swellings called “buboes” on the victim’s lymph nodes. By the time the plague left, Europe’s population had been reduced by almost half. The devastation as a result of the plague may seem shocking, but there were several important factors that contributed to its deadliness.
The Black Death, also known as the Black Plague and Bubonic Plague, was a catastrophic plague that started out in Asia and began to spread into Europe. In the span of three years, the Black Death killed about one third of all the people in Europe. The plague started out in the Gobi Dessert in Mongolia during the 1320’s. From the desert the plague began to spread outwards in all directions. China was among the first to suffer from the plague in the early 1330s before the plague hit Europe.
Mycobacterium tuberculosis (MT) is a slender, rod-shaped, aerobic bacillus which causes tuberculosis. Tuberculosis (TB) is an airborn infection which is transmitted via inhaling droplet nuclei circulating in the air. These droplets are expelled from the respiratory secretion of people who have active TB through coughing, sneezing, and talking (Porth, 2011). Some bacilli stay in the upper airway and are swept out by mucus-secreting goblet cells and cilia on the surface of the airway. Others will escape from this protective mechanism to travel and settle down at alveoli (Porth, 2011). Local inflammatory reaction occurs and macrophages are cells that act as next line defense mechanism to fight with mycobacteria. First they engulf micobacteria, try to reduce their strength and ability, and kill them. In the same way they send antigen to helper T lymphocytes to initiate a cell-mediated immune response (Knechel, 2009). The infected macrophages will send produced cytokines and enzymes to breakdown mycobacteria’s protein. It is the released cytokines that attract T ly...
According to World Health Organization, the statics show that: - The world needs 17 million more health workers, especially in Africa and South East Asia. - African Region bore the highest burden with almost two thirds of the global maternal deaths in 2015 - In Sub-Saharn Africa, 1 child in 12 dies before his or her 5th birthday - Teenage girls, sex workers and intravenous drug users are mong those left behind by the global HIV response - TB occurs with 9.6 million new cases in 2014 - In 2014, at least 1.7 billion people needed interventions against neglected tropical diseases (NTDs) (“Global Health Observatory data”, n.d.) B. A quote of Miss Emmeline Stuart, published in the article in
One of the first steps to treating Tuberculosis is identifying which form has developed in the body. The two forms that could progress in the body are latent Tuberculosis infection and active Tuberculosis infection (CDC, Morbidity and Mortality Weekly Reports). Latent Tuberculosis is the dormant form of the bacteria, meaning that it is inactive and doesn?t cause an infectious reaction in the body. Even if the latent form enters the body, treatment should be sought (CDC, Morbidity and Mortality Weekly Reports). Latent Tuberculosis can become active Tuberculosis easily though, especially if the immune system is compromised by another infection, like HIV (CDC, Morbidity and Mortality Weekly Reports). Active Tuberculosis infects the body immediately. Symptoms show in the body meaning the bacteria is effecting the cells of the body. Identifying the form is important because treatment is dependent upon it. Testing for TB involves a skin test, usually within seven work-days of contact with the bacteria. Without knowing what is in the body, the drugs won?t be as effective and might even cause drug-resistance.
is positive; three Sputum Test reveals if TB germs are in thick liquid a person
The bubonic plague was a horrifying plague that wiped out about 1/3 of the world’s population. The bubonic plague travelled very quickly but some question what it was that caused it to travel so quickly. In analyzing the fact that infectious droplets, human choices and trade were all major factors of the spread, one can conclude that humans had a major impact on the spread of the Bubonic Plague.
Tuberculosis is an air-borne disease, hence, it can be passed from an infected person to a healthy individual through coughing, sneezing and other salivary secretions. Tuberculosis is caused by the transfer of Mycobacteriun Tuberculosis (M. Tuberculosis) also known as Tubercle Bacillus, a small particle of 1-5 microns in diameter, due to the small size, when an infected person sneezes or coughs, about 3,000 particles are expelled. M. Tuberculosis responsible for tuberculosis is able to stay in the air for a long period of time (about 6hoursAnother way of acquiring Tuberculosis is by drinking unpasteurized milk, milk straight from cow, although this is not a common mode of transmission, it can be found in rural areas. Ingestion of contaminated cow milk transmits Mycobacterium Bovis, the animal form which is still potent enough to cause tuberculosis in humans. ). Tuberculosis transmission is affected by exposure, socioeconomic status of person, proximity, immune status of uninfected individual (%&&%&? CDC).
Mycobacterium tuberculosis is a nonmotile, acid-fast, obligate aerobe. The bacilli are 2-4 um in length and have a very slow generation time of between 15 and 20 hours. The cell wall of the mycobacterium is unique in that it is composed mainly of acidic waxes, specifically mycolic acids. M. tuberculosis is unusually resistant to drying and chemicals, contributing to the ease with which it is transmitted.
Wines, M. 2007. Virulent TB in South Africa may imperil millions. New York Time. January 8. Accessed online at http://www.nytimes.com/2007/01/28/world/africa/28tuberculosis.html?pagewanted=all
... about Pakistan, where I live there very less hospitals at the moment which provide proper care to patients and if the hospital beds would be full of such patients then other people whose diseases can be cured would not be treated properly.
In Australia in the last ten years more then 137 known people have died and many more fallen very ill from contagious and infectious disease. Diseases such as diphtheria; tetanus, pertussis, poliomyelitis, measles, mumps rubella and Haemophilus influenzae, This is a great tragedy considering all these diseases are easily preventable by immunisation.
Tuberculosis has plagued mankind for a long time. This disease, which was previously believed to be eradicated, has once again shown up and begun attacking the lives of many humans. Tuberculosis infects a third of the population and kills a fraction of them. Many approaches have been used including different varieties of infection control, bodily defenses, and treatments to try to protect humans from tuberculosis. The best way to prevent tuberculosis infections is to contain the source of tuberculosis. The most common source of tuberculosis infection is from infected humans. By diagnosing, containing, and treating people with latent tuberculosis before they get active, contagious tuberculosis, tuberculosis can be quickly contained. Once someone has been diagnosed with TB, they should be placed under isolation.
The disease can be caused by different mycobacterium such as Mycobacterium bovis, M. africanum, M. canettii, M. microti, and most commonly, M. tuberculosis; although the five are highly similar and are together termed the Mycobacterium tuberculosis complex (MTBC). Recently, two additional organisms. Mycobacterium pinnipedii and Mycobacterium caprae have also been implicated with the disease in humans. 6, 7 Members of the MTBC are gram-positive, long, rod-shaped bacterium with unique characteristics such as an exceptionally slow growth rate and a high content of lipids in their cell wall which provide protection against degradation and may account for their persistent survival in the environment even after the death of a host. 8