Trimethylaminuria

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In 1970, the first clinical case of trimethylaminuria (TMAU) was found by J.R Humbert, when diagnosing a 6-year old girl. Trimethylaminuria is a rare, genetic, metabolic disorder in which the bodily fluids being excreted contain Flavin Containing Monooxygenase 3, or FMO3. The FMO3 gene is unable to breakdown Trimethylamine (TMA) into Trimethylamine N-Oxide in a natural bodily process. The FMO3 protein oxidases a chemical reaction within the bodily fluids that allow Trimethylamine to break down into a non-pungent chemical, Trimethylamine N-Oxide (TMAO). Trimethylamine is the chemical compound that is responsible for the strong fishy odor in bodily fluids. When FMO3 proteins are working, the Trimethylamine is converted into the Trimethylamine

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