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Case study of graves disease
Thyroid dysfunction
Graves disease pathology
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The thyroid, part of the endocrine system, is a butterfly shaped organ located in the neck superior to the collarbone and inferior to the Adam’s apple. It consists of two lateral lobes, which are then connected by a median tissue mass called the isthmus. Also, the thyroid helps in maintaining metabolism (process by which cells use energy) by producing two hormones known as triiodothyronine (T3) and thyroxine (T4). In an over productive thyroid (hyperthyroidism), T3 and T4 are going to be overproduced, leading to an overactive metabolism essentially causing irregular/rapid heartbeat, weight loss, irritability, and nervousness (U.S. National Library of Medicine). Studies have shown, that hyperthyroidism is more common in women than men, patients with thyroid issues, and people over 60 years of age (Queenn, 2005). Other factors and diseases that influence hyperthyroidism include Graves’ disease (most common cause), intake of iodine consumption, and tumors of the testes or ovaries (Uzelac & Moon, 2005). Hyperthyroidism can also lead to mechanical problems within the body which include heart problems associated with atrial …show more content…
Graves’ disease, a factor that contributes to hyperthyroidism, can also be obtained at any age, but is rare before the age of 10 and is more likely to be seen between the ages of 40-60. With a women’s increased risk of obtaining hyperthyroidism, also comes the risk of obtaining Graves’ disease. In a ratio of women to men, for every seven women with Graves’ disease, only one man will obtain the disease (U.S. National Library of Medicine). The Japanese culture has a greater risk for hyperthyroidism, because their diet of saltwater fish tends to have greater amounts of iodine. Also, switching from a diet that has low to no iodine to numerous amounts of the substance can lead to hyperthyroidism (Uzelac,
My case study was based on a women name Margie. Margie is a 50 year-old women that frequently exercises and maintains a healthy eating habit. Even though Margie is a fit 50 year-old her cholesterol was well above average 222. Her trainer then recommended her to sign up for extra kickboxing class and maintain a vegetarian low fat diet, therefore her cholesterol would decease. About a month later she tested her cholesterol again and after the extra exercise, low fat diet her cholesterol was higher than the previous time at 230. Therefore, Margie attended the doctor where she was diagnosed with hypothyroidism.
Hypothyroidism develops when the thyroid gland does not produce enough of certain hormones. (“Hypothyroidism”, n.d.). Hypothyroidism can be broken down even further. The two types of hypothyroidism are congenital hypothyroidism or acquired hypothyroidism. According to Porth 2011, “Congenital hypothyroidism develops prenatally and is present at birth. Acquired hypothyroidism develops later in life because of primary disease of the thyroid gland or secondary to disorders of hypothalamic or pituitary origin.” (p. 786). Some common symptoms include increased sensitivity to cold, dry skin, fatigue, constipation, drowsiness, hypothermia and muscle weakness (“Hypothyroidism”, n.d.).
Society for Endocrinology. (2010, March 15). May be safe for patients taking thyroxine to have lower TSH levels than currently recommended, new research shows. ScienceDaily. Retrieved March 30, 2014 from www.sciencedaily.com/releases/2010/03/100315230910.htm
Graves’ disease is an autoimmune disease that was discovered by Robert Graves in 1835. Graves’ disease is an autoimmune disease in which the body's immune system attacks the thyroid gland and causes hyperthyroidism. Graves’ disease occurs when the antibodies like thyroid-stimulating immunoglobulin and thyrotropin receptor antibodies (TRAbs) attack the thyroid gland as if it were a foreign object or a virus of some sort. This disease is the most common type of hyperthyroidism. Attacking the thyroid gland in such a manner makes it excessively overproduce the hormone thyroxine which controls the body’s metabolic rate. Heightened activity of the thyroid can increase the body’s metabolism by 60% to 100%. (Weeks 34-35).
Today in America thyroid disease is becoming a much larger issue and the worse part of this problem is that many people are not yet diagnosed. This is due to the lack of education and awareness about thyroid disease. There are many different types of diseases but the one that I am passionate about is hypothyroidism. Hypothyroidism, or underactive thyroid is when the thyroid is no longer able to produce triiodothyronine, also known as T3 and thyroxine, also referred to as T4. Some of the symptoms include unexpected weight gain, tiredness, depression, or slow movements and thoughts. Most of the time many people notice the way that their bodies act on what they are feeling to their physicians. Many Americans struggle with this disease that
There has been conflicting research and advice about the safety of hormones with the increase in the aging female population within the last twenty years (National Institute on Aging). Hormone therapy has demonstrated to be the most effective FDA approved medication in the relief of menopausal symptoms, but these benefits must be weighed against serious adverse effects that hormones can cause. Although many women differ in their response to hormone products, MHT has been universally linked to an increased risk of heart disease, heart attack, blood clots, and strokes. Concerns about the findings discovered in the clinical and observation trials performed on MHT, have left some doctors and women hesitant in utilizing MHT to combat menopausal symptoms.
Thyroid cancer is an abnormal and malignant cell growth in the thyroid gland (see figure 1). The wellbeing of a person’s thyroid gland is extremely important, as this organ secretes hormones and other chemicals that help a person maintain homeostasis, more specifically the weight, blood pressure, heart rate, and internal body temperature (Bethesda, National Cancer Institute). According to the Mayo Clinic, although it is not yet clear to researchers what exactly causes thyroid cancer, what medical scientists do know is why it occurs. One type of thyroid cancer that can be genetic is medullary thyroid cancer. This type of cancer is genetic because it is linked with a variety of risk factors that could lead up to cancer, such as gender, age, radiation exposure, hereditary conditions, and family history (“What Are the Risk Factors for Thyroid Cancer?”). A major specific cause of thyroid diseases and cancers is insufficient iodine intake. Thyroid cancer is less common in the United States, than places that do not include as much iodine in the diet because in the United States, iodine is often added to many foods and consumption products. An environmental factor that is associated with thyroid cancer is exposure to radiation. One major example of this is the radiation from the Chernobyl incident; many people were affected by the radiation and many people, especially children, developed thyroid cancer (“What Are the Risk Factors for Thyroid Cancer?”).
The balance of the thyroid hormone is complicated and involves the participation of different parts of the body (Kaplustin, 2010).
The thyroid gland plays a major role in the endocrine, thyroxine, triiodothyronine and metabolism system. The gland can be found in the front of the neck and above where the collar bones meet. The thyroid gland controls the body by releasing T4 and T3 hormones. Controlling metabolism plays an important role when regulating mood, weight,
The thyroid gland is found in the front of the neck and produces two main hormones. The hormones are called thuroxine (T4) and Triiodothyronine (T3). Together these hormones regulate the body’s metabolism by increasing energy use in cells, regulate growth and development, help to maintain body temperature and aid in oxygen consumption. These two hormones are regulated by hormones produced by the hypothalamus and pituitary gland. The hypothalamus senses changes in body’s metabolic rate and releases a hormone known as thyropin-releasing hormone (TRH). This hormone then flows through connecting vessels to the pituitary gland which signals it to release another hormone. This hormone is known as thyroid-stimulating hormone (TSH). TSH then makes its way to the bloodstream until it reaches the thyroid where it is then signaled to activate T3 and T4 production [1]. This mechanism is controlled by a negative feedback loop meaning that when there is a sufficient amount of thyroid hormones in the blood stream, this will signal back to stop production of thyroid stimulating hormones. Complications occur when the thyroid hormones keep increasing even though there is already a sufficient amount of T3 and T4 in the blood stream. This process of over expression of thryroid hormones is known as hyperthyroidism. Hyperthyroidism is a general term that includes any disease that has a consequence of an overabundance of thyroid hormones. Hyperthyroidism is a general term but there are many variant diseases that are in the hyperthyroidism category. These diseases include diffuse toxic goiter, Basedow’s disease, thyrotoxicosis, Parry’s and Graves’ disease.
Among these disorders are hypothyroidism and hyperthyroidism. Hypothyroidism is a disorder in which one is diagnosed for having and underactive thyroid. The probability for women over the age of sixty to develop an underactive thyroid is higher than those of other individuals. If left untreated it can potentially lead to obesity, joint pain, heart disease, and other health complications. On the contrary, hyperthyroidism is a disorder in which a person is diagnosed for having an overactive thyroid. This can cause nervousness and anxiety, hyperactivity, unexplained weight loss, and swelling of the thyroid gland which causes a noticeable lump to form on throat (known as a
middle of paper ... ... sk for cancer. There is no need to be alarmed with high levels of contaminants when it comes to consuming any kind of salmon. What we do need to be alarmed about is the media reporting and their level of contaminants! Ronad A. Hites, Jeffery A. Foran, David O. Carpenter, M. Coreen Hamilton, Barbara A. Knuth, Steven J. Schwager (2004) study: Global assessment of organic contaminants in farmed salmon, Science 303:226-229.
Our patient has 4 of the 5 risk factors: low HDL, high triglycerides, high fasting blood glucose, and central obesity. Because of this, she does seem to have metabolic syndrome. With metabolic syndrome concomitant disease states occur that the patient may have, including PCOS, and hypothyroidism.
Sushi is filled with fresh ingredients such as fish, vegetables, and fiber-filled rice which are loaded with nutrients which are a very healthy meal choice. Also, traditional rolls made with these fresh ingredients are low in calories. For example, the shrimp roll is only about 200 calories with no trace of fat. When you eat these rolls, you are ingesting many nutrients such as vitamin A, B-6 and C. Sushi also provides the important nutrient known as Iodine which is lacking in America. Iodine is an essential for good thyroid health which comes from the seaweed that the sushi rolls are wrapped in. Additionally, a 2011 review published in the "Journal of Agricultural and Food Chemistry" concluded that the proteins in the seaweed could reduce blood pressure and improve heart health (Collins). The fish or seafood in the rolls also has nutritional
Congenital hypothyroidism is the most common disorder identified by routine newborn screening. It is found in about 1:3000 screened infants (Dussault, 1993). The major clinical features of untreated congenital hypothyroidism are growth retardation and delayed cognitive development leading to mental deficiency.