The Potential of Gene Therapy to Cure Diabetes
Abstract
Gene therapy treats and prevents a disease by introducing a vector of genetic material into certain cells to alter the function or ability of a gene. The promise of gene therapy as a cure for diabetes has been considered ever since this new technology emerged into the clinical and research sphere. Although such methods have yet to undergo human clinical tests, gene therapy holds much potential to bring a radical new way of treating autoimmune diseases such as diabetes. By targeting certain genes that control the insulin and ?-cell production in the pancreas, gene therapy will someday fulfill its potential to cure the disease that is the number one cause of heart disease in the United States. This paper will explore the potential protocols and products that can be used to treat Type I Diabetes.
Diabetes is an autoimmune disease that has affected more than 140 million people in the world. This disease, results from the attack of the killer T-cells of the immune system upon the ?-cells in the pancreas that produces insulin. (Lin et al., 2001). Until recently, this disease could only be treated with daily insulin injections and adherence to a strict, low glucose diet. With more than ninety percent of diabetics at risk for future complications like heart disease, blindness, and renal failure, diabetes has developed into more than just a medical issue. Diabetes is also becoming largely an emotional and economic issue. Victims of this disease have no choice but to adjust their lives around the only object that could change their lives?a daily injection that may cost 50% of the annual income in developing countries and up to 600% in non-developed countries. New technology th...
... middle of paper ...
...ne Therapy, (10), 875-889.
Grey, S.T., et al. (1999). Adenovirus-mediated gene transfer of the anti-apoptotic protein A20 in rodent islets inhibits IL-1�-induced NO release. Transplantation Proceedings, (31),789.
Lin, Andrew, Cathy Huang, and Kendrick Ong. (2001). Type I AutoImmune Diabetes. Diabetes & Gene Therapy. July 21, 2005: http://dragon.zoo.utoronto.ca/~jlm2001/J01T0301B/index.html
Nitta, Y., et al. (1998). Systemic Delivery of Interleukin 10 by Intramuscular Injection of Expression Plasmid DNA Prevents Autoimmune Diabetes in Nonobese Diabetic Mice. Human Gene Therapy, (9), 1701-1707.
Rudolph, Frederick B., et al. (1996). Biotechnology: Science, Engineering, and Ethical Challenges for the 21st Century. Washington, D.C.: Joseph Henry P.
Thule, P.M. and Liu, J.M. (2000). Regulated hepatic insulin gene therapy of STZ-diabetic rats. Gene Therapy 7: 1744-1752.
During the year 1889, two researchers, Joseph Von Mering and Oskar Minkowski, had discovered the disease that is known today as diabetes. Diabetes is a disease in which the insulin levels (a hormone produced in unique cells called the islets of Langerhans found in the pancreas) in the bloodstream are irregular and therefore affect the way the body uses sugars, as well as other nutrients. Up until the 1920’s, it was known that being diagnosed with diabetes was a death sentence which usually affected “children and adults under 30.” Those who were diagnosed were usually very hungry and thirsty, which are two of the symptoms associated with diabetes. However, no matter how much they ate, their bodies wouldn’t be able to use the nutrients due to the lack of insulin. This would lead to a very slow and painful death. In 1922, four Canadian researchers by the names of Frederick G. Banting, Charles H. Best, John J.R. MacLeod, and James B. Collip had discovered a way to separate insulin in the pancreas of dogs and prepare it in such a way so that it can be used to treat diabetic patients. In the year 2008, there were 1,656,470 people who suffered from diabetes in Canada, and by 2010, it is predicted that this disease will take over the lives of 285 million people . Although there is no cure for diabetes, the treatment of prepared insulin is prolonging the lives of diabetics and allowing them to live freely. The discovery of insulin was important and significant in Canada’s history because Banting was a Canadian medical scientist who had a purpose in finding a treatment for diabetes, its discovery has saved lives and improved the quality of life of those suffering from this disease, and it showed the world Canada’s medical technology was ...
4. Phillips B, Trucco M. Immunotherapy-based strategies for the treatment of autoimmune diabetes: searching for the cure. Current Pharmaceutical Design [serial online]. 2011;17(29):3217-3223. Available from: MEDLINE with Full Text, Ipswich, MA. Accessed November 19, 2013.
To conclude, although gene therapy can cure a wide variety of diseases which cannot be cured by traditional medicine, and patients can get permanent cure without rejections, it can be high-risk and immoral. The negative effects of gene therapy lead to the shrink of the number of volunteers, and many trials have been forced to cease. The Gene therapy's potential to revolutionize medicine in the future is exciting, and hopes are high for its role in curing and preventing childhood diseases.
Science and technology are rapidly advancing everyday; in some ways for the better, and in some, for worse. One extremely controversial advance is genetic engineering. As this technology has high potential to do great things, I believe the power genetic engineering is growing out of control. Although society wants to see this concept used to fight disease and illness, enhance people 's lives, and make agriculture more sustainable, there needs to be a point where a line is drawn.
Since Egyptians described diabetes in their manuscript and Indian physicians identified diabetes around 1500 BC, lots of discoveries are made regarding the pathogenesis and the treatment of diabetes: new technologies are invented and used in the diagnosis and treatment of diabetes, type-1 and type-2 diabetes are differentiated through time, lots of researches are done to find out a lasting solution to the devastating disease. Regardless of all the effort made diabetes type-1 remains incurable. It still continues to be one of the causes of death. The Genetics Home Reference web page noted the occurrence of type-1 diabetes in 10 to 20 per 100,000 people per year in the United States. By age 18, approximately 1 in 300 people in the United States develop type 1 diabetes. Worldwide, the number increases every year by 2 to 5 percent. (Genetics Home Reference, 2013)
The types of diseases that can be treated by gene therapy are those where replacement of a single gene is able to cure the disorder. Some of the main diseases currently being researched in gene therapy studies include cancer, hemophilia, sickle cell anemia, muscular dystro...
Genetic engineering has revolutionized over the years and it is being used to improve food, to discover new medicines, to remove environmental contaminants, to recycle waste, and to provide permanent cures for inherited diseases (Le Vine, 1999). The purpose of genetic engineering in the medical field has been to produce mass-produce insulin, human growth hormones, human albumin, monoclonal antibodies, vaccines, and many other drugs (Applications of Genetic Engineering,
Since its inception, gene therapy has captured the attention of the public and ethics disciplines as a therapeutic application of human genetic engineering. The latter, in particular, has lead to concerns about germline modification and questions about the distinction between therapy and enhancement. The development of the gene therapy field and its progress to the clinic has not been without controversy. Although initially considered as a promising approach for treating the genetic of disease, the field has attracted disappointment for failing to fulfil its potential. With the resolution of many of the barriers that restricted the progress of gene therapy and increasing reports of clinical success, it is now generally recognised that earlier expectations may have been premature.
... middle of paper ... ... Retrieved December 29, 2013, from http://www.dnaforensic.org/index.html. What is Biotechnology? n.d. - n.d. - n.d.
Webber, G. D. Regulation of Genetically Engineered Organisms and Products. Office of Biotechnology | Iowa State University Office of Biotechnology. Retrieved September 22, 2013, from http://www.biotech.iastate.edu/biotech_info_series/bio11.html - anchor96278
Coker, Jeffrey Scott. "Genetic Engineering Is Natural and Should Be Pursued." Genetic Engineering, edited by Noël Merino, Greenhaven Press, 2013. Opposing Viewpoints. Opposing Viewpoints in Context,
As human technological innovation proceeds into the twenty-first century, society is faced with many complex issues. Genetic engineering and cloning, encryption and information security, and advanced weapons technologies are all prominent examples of technological issues that have substantial moral and ethical implications. Genetic engineering in particular is currently a very volatile subject. One important aspect of this field is GMO or Genetically Modified Organisms, which has far-reaching potential to revolutionize modern agriculture. GMO crops are already being developed by many leading biotech companies, and have come under intense scrutiny by society. This is easily understood, however, because there is not much that is more important than how people get fed. Specifically, where their food comes from, and how it is produced. Thus, it is essential that we examine the ethical dilemmas as well as the practical benefits posed by such a powerful technology.
Gene therapy enables patients to survive incurable diseases. In the field of genetic diseases, ADA-SCID, CGD and hemophilia are three main ones. ADA-SCID is known as the bubble boy disease. CGD is related to immune system that would lead to fungal infections which are fatal. Patients with Hemophilia are not able to induce bold bleeding (Gene therapy for diseases, 2011). Gene therapy also has good effects on cancer treatment and neurodegenerative diseases, which include Parkinson’s disease and Huntington’s disease. Viral infections, including influenza, HIV and hepatitis can also be treats by it (Gene therapy for diseases, 2011). According to the Science Daily in 2011, gene therapy now can apply to heart failures and neurologic diseases as well.
Imagine not being able to have a snack or candy whenever you want to in a day. Many people have to watch what they eat, especially diabetics because of lack of insulin in their bodies. They have to watch their sugar intake daily and also keep up with insulin shots. Diabetes is a life long disease which isn’t easy to have without new technological advancements. The rapid growth of technology has made health care more successful, specifically in the advancements for the cure and treatments of diabetes.
This means that the ethicality for synthetic biology is mostly based on predictions for the future. However, the ethicality of synthetic biology can be determined by applying the principles of laws for bioethics and emerging technologies to these factors. Social implications are the most important factor when it comes to considering how ethical a technology is. As of 2010, the Presidential Commision for the Study of Bioethical Issues developed a set of basic principles to assess emerging technologies based on some of their social