The Importance Of Requalification

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Requalification Requalification should be done in accordance with a defined schedule. The frequency of requalification may be determined on the basis of factors such as the analysis of results relating to calibration, verification and maintenance. There should be periodic requalification, as well as requalification after changes (such as changes to utilities, systems, equipment; maintenance work; and movement). Requalification should be considered as part of the change control procedure. 2.8) Revalidation • Processes and procedures should be revalidated to ensure that they remain capable of achieving the intended results. • There should be periodic revalidation, as well as revalidation after changes. • Revalidation should be done in …show more content…

of calibration, maintenance and cleaning); and o Analytical methods. Revalidation after change Revalidation should be performed following a change that could have an effect on the process, procedure, and quality of the product and/or the product characteristics. Revalidation should be considered as part of the change control procedure. The extent of revalidation will depend on the nature and significance of the change(s). Changes should not adversely affect product quality or process characteristics. Changes requiring revalidation should be defined in the validation plan and may include: • Changes in starting materials (including physical properties, such as density, viscosity or particle size distribution that may affect the process or product); • Change of starting material manufacturer; • Transfer of processes to a different site (including change of facilities and installations which influence the process); • Changes of primary packaging material (e.g. substituting plastic for glass); • Changes in the manufacturing process (e.g. mixing times or drying temperatures); • Changes in the equipment (e.g. addition of automatic detection systems, installation of new equipment, major revisions to machinery or apparatus and

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