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Effects of teratogens on prenatal development
Lifestyle effects of teratogens
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Recommended: Effects of teratogens on prenatal development
Childbirth is nothing short of a miracle. The placenta—the organ connecting a developing fetus to the uterine wall and allowing for waste elimination, nutrient uptake and gas exchange via the mother's blood supply—filters most harmful substances that threaten an embryo, though some may still pass on to the fetus. These harmful substances, called “teratogens,” range from environmental chemicals to the passing of maternal diseases, and can negatively impact the normal developmental cycle of a fetus. The title “teratogen,” however, effectually refers to any substance or chemical exposure with the potential to cause birth defects in prenatal development. Exposure to teratogens can result in a broad spectrum of physiological and psychological issues in later life, including malformations of the body. (Malformations resulting from exposure to one of the most common teratogens—alcohol—can be observed notoriously in Fetal Alcohol Syndrome, or FAS, where patterns of mental and physical defects develop in association with high levels of alcohol consumption during pregnancy.) Though the toxicity of these teratogens is particularly damaging during the fourth through tenth weeks of gestation, teratogens can harm throughout the span of development in the womb. The manner in which a teratogen impacts the developing human may vary, though nicotine, caffine and medication consumption are all directly related to physical development. These are examples of habitual teratogens, each contributing to low birth weight and behavioral problems in adolescents. The level of influence of any given teratogen depends on many factors; the first, called the “threshold effect,” occurs when a relatively harmless teratogen in small quantity becomes toxic at a spe... ... middle of paper ... ...ve physical deformities, decreased birth weight and respiratory difficulties. The drugs can also carry adverse behavioral effects, including high pitched crying, abnormal sleep patterns and decreased attention. Studies have determined that some infants can rectify these behavioral inconsistencies, but that the change is dependent upon a responsive caregiver in a nurturing environment. The birth of a healthy child is a blessing. The prenatal period is susceptible in terms of embryonic development, and some exposures to teratogens can have adverse and lifelong affects on a baby. Although physical outcomes resulting from teratogen exposure cannot be reversed, with hope, some of the behavioral effects of Teratogens may have a decreased impact on the life of the child, though all mothers should pay special attention to the health of their child throughout their pregnancy.
The Centers for Disease Control and Prevention suggestion that a pregnant woman should not drink alcohol during pregnancy (Advisory on alcohol use in pregnancy 2005) has been widely criticized as being unnecessarily paternalistic, but the CDC goes further into explaining that, “Alcohol consumed during pregnancy increases the risk of alcohol related birth defects, including growth deficiencies, facial abnormalities, central nervous system impairment, behavioral disorders, and impaired intellectual development” (Advisory on alcohol use in pregnancy
Chemical pollution into the environment can cause both genotypic and phenotypic changes in many organisms, including humans. More specifically, environmental pollutants like BPA can act as xenoestrogens (estrogen imitators), ultimately affecting hormonal activity and production in an organism. This alteration in activity and production can be termed as endocrine disruption. The endocrine system regulates a variety of processes responsible for growth and development, including gonadal formation and function, digestion, metabolism, sex differentiation, and embryonic development (reviewed by Flint et al., 2012). Chemicals that interfere with the function or structure of the endocrine system can be defined as endocrine disrupting compounds (EDCs) (US Environmental Protection Agency, 2007).
The intake of drugs and alcohol during pregnancy can cause many different birth defects. Drugs and alcohol can easily reach the baby while inside the mother. When a pregnant woman consumes a drug or some alcohol it enters into her bloodstream, then makes its way to the placenta. When it reaches the placenta it travels through the umbilical cord to the baby’s body (Schniderman pg. 27). Once it reaches the bay it can cause a lot of different problems. Drinking alcohol can cause the baby to be born with Fetal Alcohol Syndrome. If too much alcohol gets into the baby’s bloodstream the baby will most likely have FAS. Fetal Alcohol Syndrome can affect an infant after it is born or even later on in life. Kids with Fetal Alcohol Syndrome can be impulsive at times, and they tend to not learn from their own mistakes and behavior unlike other children (Stewart pg. 47). Having a child with FAS could be very hard. They have difficulties trying to learn certain things. Learning from mistakes make life so much easier, and having a child who cannot do that could be very stressful. Many people put the...
The affects teratogens can have on the developing fetus can vary greatly. Research provided from the University of Iowa’s on teratogens explains some of the possible outcome to exposure to certain teratogens. Listed birth defects resulting from exposure to teratogens, range from prenatal death, to physical and mental abnormalities.
Many studies have established that a developing organism is susceptible to exogenous and endogenous factors during certain stage of the organism’s development. The effects of ethyl alcohol or ethanol on the developing fetus, which manifest a variety of characteristic abnormalities, are collectively called Fetal alcohol Syndrome. Ethanol exposure to the fetus causes various malformation ranging from the cellular to the organismic levels with the eventual results frequently being different levels of mental retardation (3).
The first trimester of pregnancy is the most sensitive trimester for a developing fetus. There are a few different ways that mothers and fetuses can be exposed during this sensitive time. They can be exposed accidentally, knowledgably, or with no knowledge of the pregnancy. An example of an accidental exposure is a radiation accident, like Chernobyl. There was no way to record the actual dosage of radiation that each child received in utero, or the amount of women who had spontaneous abortions after being exposed to the accidental radiation. It has been shown that those babies “exposed during the most sensitive period of pregnancy performed less well [on verbal IQ tests] than those who were exposed after week 16 of pregnancy” (Heiervang 213). There appear to be more significant birth defects and abnormalities in fetuses who were exposed prior to the 16 week gestational mark.
During recent years, numerous newspaper and magazine articles have suggested that humans may be at risk because small amounts of well known environmental contaminants, such as dioxin, PCBs and DDT, can affect hormone levels. Hormones are produced by the endocrine system as regulators of biological function in target organs. Because hormones play a critical role in early development, toxicological effects on the endocrine system often have an impact on the reproductive system. The term endocrine disruptor is used to describe chemicals that can mimic hormones and may either enhance or counteract their effects. It has been suggested that these hormone changes can, in turn, lead to a variety of health problems including cancer, decreased fertility, and abnormalities in newborns.
Development is a never ending cycle in life. Each person begins to develop from conception until passing away. Now, while most people think that development starts after birth that is incorrect. Development starts as soon as the baby is conceived. Everything that a woman carrying a baby does or takes place in will translate into the baby. The baby shares a blood flow with the mother. Drugs, even legal drugs, will go into the mother’s blood stream which will then go into the baby’s blood stream. The “maternal blood flows through the uterine arteries to the spaces housing the placenta, and it returns through the uterine vein to the maternal circulation” (Santrock, 2012, p. 80). This means that anything that enters into the blood stream will also affect the baby. Each type of drug is under a certain category. Psychoactive drugs are drugs that are constantly being studier. According to Santrock (2012), psychoactive drugs are drugs that act on the nervous system to alter states of consciousness, modify perception, and change moods. (p.83). They come in three categories: stimulants, depressants, and hallucinogens. Stimulants include caffeine, cocaine, methamphetamine and nicotine. Some people say that pregnant woman do not know what taking these into their system is doing to their baby. Stimulants are becoming more popular and there effects need to be studied and known. Each stimulant affects the baby in short-term and long-term.
...an infant is living in, and how he or she would get treat in the first three years, would get effect on his or her behavior. “ Babies’ brains are searching for clues about the world that they are entering, trying to predict what settings will best adapt them to the life ahead” (Patty 127). When the baby does not see any care, any kind of emotion in its life, they would grow up as an unemotional person, because the person’s brain did not process the steps of learning empathy in its life. “A baby is born with just one suite of genes. If they can produce only one pattern of responses, that pattern could turn out to be fatally maladaptive” (Patty 128). The baby is capable of learning whatever the environment is giving him to learn. Children may seem they don’t understand everything that goes around him or her, but it’s from that children will understand how to behave.
When a woman is pregnant it is recommended that she does not consume any alcohol. If a woman does consume alcohol during the pregnancy she can cause a disorder called Fetal Alcohol Syndrome (Rank, J.). In 1968, Fetal Alcohol Syndrome was characterized by P. Lamoine and colleagues form Nantes. They reported their findings in the French pediatric journal but unfortunately it didn’t draw to much attention. Five years later, in 1973, it was characterized again by K.L. Jones and colleagues in Seattle. Unlike the report in 1968 that wasn’t a success, this report in the British medical journal, The Lancet, triggered a great amount of reporters of Fetal Alcohol Syndrome (Perlstein, David, MD, FAAP). The disorder is characterized by brain problems, abnormal facial features, growth defects, and organ defects (Rank, J.) Alcohol is considered a teratogen and is the most common cause of mental retardation. “According to research published in Pediatrics, alcohol use among women of childbearing age (18-44 years) constitutes a leading, preventable cause of birth defects and development disabilities in U.S.” (Perlstein, David, MD, FAAP). Even though the disorder is preventable, the defects are not irreversible or unchangeable (Mayo Clinic Staff).
Jancárková, N., & Gregor, V. (2000). [Teratogens during pregnancy]. Ceska gynekologie/Ceska lekarska spolecnost J. Ev. Purkyne, 65(3), 188-194.
Another study measured the levels of flame retardants in both mothers’ prenatal and their children’ serums, and found that high concentrations of flame retardants like polybrominated diphenyl ethers were associated with a poorer attention than normal, slower cognitive development, and motor coordination difficulties. (Hamers, 2017)
(Gilman, Breslau, Subramanian, Hitsman, & Koenen, 2008). Despite the warnings about the dangers of smoking while pregnant, some women still choose to smoke, which places themselves and their baby at risk for many health issues. Damage caused by smoking while pregnant During pregnancy, smoking can cause problems for a woman’s own health, including, ectopic pregnancy, vaginal bleeding, placental abruption, in which the placenta peels away, partially or almost completely, from the uterine wall before delivery; Placenta Previa, a low-lying placenta that covers part or all of the opening of the uterus (March of Dimes, 2011). Women that smoke expose their unborn baby to dangerous chemicals, like carbon monoxide, tar and nicotine.... ...
The internal female anatomy that allows for reproduction is extremely particular. Starting in the ovary, otherwise known as the female gamete, eggs or oocytes are produced. These eggs, once fertilized can complete the process of meiosis, where daughter cells are formed. These daughter cells supply the embryo with its chromosomes in order to fully develop. Problems can also arise once sperm fertilizes an egg. Birth defects that follow patterns throughout a family line would be considered genetic or inherited. Teratogens are classified as any substance that may cause negative effects upon a developing fetus or embryo. For instance, substances such as alcohol and tobacco during pregnancy have been widely known to cause birth defects and can even lead to miscarriages. My focus is a study by Alan S. Brown, which proposes that alongside teratogens and genetic makeup, certain prenatal infections are leading to a birth defect that does not appear right at birth, but emerges as an adult: schizophrenia.
In recent years it has become clear that some environmental chemicals can cause risks to the developing embryo and fetus. Evaluating the developmental toxicity of environmental chemicals is now a prominent public health concern. The suspected association between TCE and congenital cardiac malformations warrants special attention because TCE is a common drinking water contaminant that is detected in water supplies throughout the U.S. and the world. There is a lot of concern about the clean up of toxic pollutants from the environment.