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Importance of research methods in science
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Robert Gallo and the Role of HIV in AIDS
Introduction
In 1982, Robert Gallo from the National Cancer Institute in the USA, put forward the hypothesis that the cause of AIDS is a retrovirus. One year later, Myron Essex and his colleagues (1) found that AIDS patients had antibodies to the Human T-cell Leukemia virus Type-1 (HTLV-I), a virus discovered by Gallo a few years earlier. At the same time, Gallo and his colleagues (2) reported the isolation of HTLV-I from AIDS patients and advocated a role for this retrovirus in the pathogenesis of AIDS. This hypothesis however, was not without a few problems:
1. While HTLV-I was accepted to induce T4-cell proliferation and cause adult T-cell leukaemia,(3) the "hallmark" of AIDS was T4-cell depletion, and the incidence of leukaemia in AIDS patients was no higher than in the general population;
2. The highest frequency of antibodies to this virus was found in Japan, yet no AIDS cases had been reported from that country;(4)
3. In the same month in which Gallo's and Essex's groups reported their data, Luc Montagnier and his colleagues from the Pasteur Institute, described the isolation of a retrovirus, later known as Lymphadenopathy Associated Virus (LAV), from the lymph nodes of a homosexual patient with lymphadenopathy.(5) Although this virus was similar to HTLV-I, one of its proteins, a protein with a molecular weight of 24,000 (p24), did not react with monoclonal antibodies to the HTLV-I p24 protein. Samples of this virus were, on several occasions, sent to Gallo's laboratory.
In May 1984, Gallo, Popovic and their colleagues published four papers in Science in which they claimed to have isolated from AIDS patients, another retrovirus, which they called HTLV-III.(6,7,8,9) On the 23rd of April 1984, before the Science papers were published, Gallo and Margaret Heckler, the then Health and Human Services Secretary called a press conference to announce that Gallo and his co-workers had found the cause of AIDS and had developed a sensitive test to show whether the "AIDS virus" is present in blood.
In 1985, the Pasteur Institute alleged that Gallo had misappropriated LAV in developing the blood test. The ensuing conflict, which reached the American courts, was eventually settled by a negotiated agreement signed in 1987 by Gallo, Montagnier, US President Reagan and French Premier Chirac. The agreement declared Gallo and Montagnier to be co-discoverers of the AIDS virus, presently known as the Human Immunodeficiency Virus (HIV).
“The Terrifying Normalcy of AIDS” is an essay written by Stephen Jay Gould, in which he talks about a dangerous disease that is spreading and becoming an issue to mankind, and that it is more of a mechanism than an irregular occurrence which I agree with. Stephen Jay Gould also shares his thoughts on our capabilities with the utilization of technology are boundless; especially when it comes to these types of ailments that threaten our kind, which is something I do not side with. Also, Stephen Jay Gould goes on to say that most people are misinformed about the disease and do not fully understand it.
...cused of being patient zero and the one who purposely and knowingly infected as many as 250 men a year on both sides of the Atlantic was nothing but one of the many wrong hypotheses made in this process of finding the origin of the HIV/AIDS virus. The fact that he had single handedly started the epidemic, today is largely discredited by most scientists. With time computer models estimated that the first human infection occurred around 1930, give or take 20 years. The earliest known infection of an identified human dates back to 1959 which was found in a plasma sample taken from an adult male living in the Belgian Congo. Many assumptions and hypotheses were made and a human eating a chimp seems to be the likeliest form the infection occurred.
2) Moore, J. (2004). The puzzling origins of AIDS: Although no one explanation has been universally accepted, four rival theories provide some important lesson. American Scientist, 92(6), 540-547. Retrieved from http://www.jstor.org.proxy.lib.sfu.ca/stable/27858482
The one factor that brings the four categories of people infected with KS is HHV-8 found in KS tissues. Although, HHV-8 is thought to be connected to KS, HHV-8 itself has very low risk factor for KS development. Most reports on KS indicate a 2% to 10% prevalence of HHV-8 in the world, but in the U.S. there is thought to be a 5% prevalence among men according to a 1970s baseline incidence of KS. In relation to HIV-1 incidence of KS increases by a factor of 20,000 to 50,000 times with the presence of HHV-8.
McNeil suggests, there are still epidemics out there which have not developed human to human status yet. For example, AIDS is identified in 1981, which is after the publication of Plagues and Peoples. Because of AIDS relevancy to this book, McNeil writes a Preface in 1997 including his thoughts on the epidemic. Humans only thought that scientific medicine "had finally won decisive victory over disease germs" (9). With the discovery of the AIDS virus a social change occurred in American and similar societies.
Acquired Immune Deficiency Syndrome (AIDS) was first recognized as a new disease in 1981 when increasing numbers of young homosexual men succumbed to unusual opportunistic infections and rare malignancies (Gallant49).During this time, many people were contacting this disease because it was not discovered yet and people did not have knowledge about it.Scientists believe HIV came from a particular kind of chimpanzee in Western Africa. Humans contracted this disease when they hunted and ate infected animals. A first clue came in 1986 when a morphologically similar but antigenically distinct virus was found to cause AIDS in patients in western Africa (Goosby24). During this time, scientists had more evidence to support their claim about this disease. Once discovered this disease was identified as a cause of what has since become one of the most devastating infectious diseases to have emerged in recent history (Goosby101). This disease was deadly because it was similar to the Black Death, it was killing majority of the population. Since its first identification almost three decades ago, the pandemic form of HIV-1 has infected at least 60 million people and caused more than 25 million deaths ...
By searching for the causative agent of infectious disease the focus can then be shifted into discovering preventative and treatment of the disease. Examples of this process are the outbreak of acquired immunodeficiency syndrome (AIDS) and bovine spongiform encephalopathy (BSE). As published by McEwen & Wills (2011), BSE was identified as a protein transmitted through the ingestion of contaminated meat. Prevention and interventions were created as a result of the discovery of the protein. Comparably, AIDS, was first identified by the Centers for Disease Control and Prevention in September of 1982, however, months passed before the causative agent was deemed a retrovirus later to be determined the human immunodeficiency virus (HIV). Even before the virus was isolated methods of transmission was recognized and interventions were acknowledged (McEwen & Wills, 2011).
The medical community had much trouble in the progress of researching the disease. In the beginning and for a period of time, the disease had no name. This was partly because no one really wanted to announce that a new disease had been discovered. After being dubbed “GRID”, an acronym singling out gays, it was changed when it was finally discovered that AIDS could be transmitted though blood transfusions and IV drug use. There was also an amazing display of medical misconduct as the head of one laboratory in the US engaged in a competition-like struggle with a lab in Paris in the research of the disease. When he finally agreed to collaborate with the French, he announced discoveries ahead of time and took all the credit for himself. This led to a long legal action that delayed much of the research of AIDS and caused many people to “die of red tape.”
In the early 1980s deaths by opportunistic infections, previously observed mainly in organ transplant recipients receiving therapy to suppress their immune responses, were recognized in otherwise healthy homosexual men. In 1983 French cancer specialist Luc Montagnier and scientists at the Pasteur Institute in Paris isolated what appeared to be a new human retrovirus—a special type of virus that reproduces differently from other viruses—from the lymph node of a man at risk for AIDS (see Lymphatic System). Nearly simultaneously, scientists working in the laboratory of American research scientist Robert Gallo at the National Cancer Institute in Bethesda, Maryland, and a group headed by American virologist Jay Levy at the University of California at San Francisco isolated a retrovirus from people with AIDS and from individuals having contact with people with AIDS. All three groups of scientists isolated what is now known as human immunodeficiency virus (HIV), the virus that causes AIDS.
HIV and AIDS have affected millions of people throughout the world. Since 1981, there have been 25 million deaths due to AIDS involving men, women, and children. Presently there are 40 million people living with HIV and AIDS around the world and two million die each year from AIDS related illnesses. The Center for Disease Control estimates that one-third of the one million Americans living with HIV are not aware that they have it. The earliest known case of HIV was in 1959. It was discovered in a blood sample from a man in Kinshasa, Democratic Republic of the Congo. Looking further into the genetics of this blood sample researchers suggested that it had originated from a virus going back to the late 1940’s or early 1950’s. In 1999, researchers had discovered that HIV is derived from chimpanzees native to west equatorial Africa. This epidemic is spreading throughout countries and infecting 14 thousand victims every day. Learning about HIV includes knowing how to contract the virus, understanding most of the people it affects, how to prevent the spread of it, and knowing what treatments are available.
In the year 1981, the condition known as Acquired Immunodeficiency Syndrome (AIDS), had a considerable impact on the health of many Americans. It was until the actual discovery of the syndrome in the early 80s that doctors suddenly gained noticed of a new form of cancer, the likes of which they’ve never encountered before, and since the syndrome’s first public outing in the United States on the summer of 1981, the number of reported cases and human casualties greatly increased due to doctors’ and health officials’ inability to understand what was actually killing them. The rise of this illness became prevalent in the 1980s because even when though it was originally thought that the disease only affected homosexual men who encountered in anal
time as well as forward. They determined that the first cases of AIDS in the
The AIDS virus is the most common disease, and with no cure, an infected person will die. It is estimated that 90 to 95 percent of AIDS infections occur in developing countries where the world’s worst living conditions exist.
Many eyebrows raised late in 1979, when the then unkown HIV virus raised its ugly head. The first two cases of the rare cancer, Karposis Sarcoma was diagnosed in two homosexual men in N>Y>C. About the same time in Los Angeles, several cases of the rare infection, Pneumocytis cariini pneumonia were being treated. Incidences of these strange diseases and infections were sky-rocketting around the country. The disease was effecting mostly young gay men in their 30's. There was no official name for the syndrome, but it was referred to by various names, GRID (gay related inmmune disease), Gay Cancer, and, "Community Acquired Syndrome". In 1982 public health officials began to use the term, Acquired Immunodeficiency Disease (AIDS) to describe the incidences of oppotunistic infections that caused AIDS. Scientists discovered the virus that caused AIDS in 1983 (HorowitzXV). According to Brennnan Durack, this was the dawning of AIDS epidemic, or the beginnning of the public's awareness of AIDS (Durack 385-386).
Dr. van Griensven explains, “However, it is clear that the first AIDS cases were recorded in gay men in Manhattan in 1979, a few years before the epidemic was first noticed in Africa in 1982.” Essentially, the first publicized cases of HIV were recorded from Africa; but, further investigations show the dates of the first ever recorded cases were even further back. Another unsettling statistic is explained by Dave Zacky, “The astounding and statistically significant fact is that 20% of the gay men who volunteered for the hepatitis B experiment in New York were discovered to be HIV-positive in 1980 (a year before AIDS became "official" in 1981)¨. With that being said, an entire fifth of the specimen the government tested on were found to be HIV positive after being experimented on; even before the disease was truly publicized. A Harvard scientist by the name of Leonard G. Horowitz tells us, “We conclude that SIV cannot become a zoonosis, but requires adaptive mutations to become HIV¨ (par. 5). Zoonosis is a disease that can be transferred from animals to humans, or vice versa; the simian immunodeficiency virus is not capable of jumping species, as Horowitz concludes. Since the disease cannot be directly transmitted, how would it have jumped species so quickly? This question remains unanswered, hence another gap in the