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Introduction of a thesis on papilloma virus
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“Human Herpes Virus-8 (HHV-8) and Kaposi’s Sarcoma (KS)”
Human herpes virus (HHV-8) poses a challenging task for researchers determining its role in Kaposi’s sarcoma (KS). People with KS are distinguished by their placement in four categories. The first category consists of elderly males of Mediterranean or Eastern European Jewish descent. The second category consists of individuals of all ages from Africa. Neither one of these categories is associated with immune deficiency or known environmental factors. The last two categories are associated with organ transplants or HIV-1. In all forms of KS males are predominantly affected.
Kaposi’s Sarcomas are known to harbor cells known as spindle shaped cells (SC). The spindle shaped cells are associated with abnormal blood vessel development and blood leakage. Although, the SC is the most frequently encountered cell in KS tumors it is undetermined if they are neoplastic cells or hyperproliferating cells or an altered cell induced by cytokines (INF-).
Although, it is easy to believe that all cells in a tumor are neoplastic, evidence suggests otherwise. There are three characteristics that are present in all KS cells whether they are neoplastic or not. The first is absence of a histologically distinguishable neoplastic cell. The second is the lack of usual chromosomal abnormalities. The last is a combination of three features angiogenesis, inflammation, and proliferation.
The one factor that brings the four categories of people infected with KS is HHV-8 found in KS tissues. Although, HHV-8 is thought to be connected to KS, HHV-8 itself has very low risk factor for KS development. Most reports on KS indicate a 2% to 10% prevalence of HHV-8 in the world, but in the U.S. there is thought to be a 5% prevalence among men according to a 1970s baseline incidence of KS. In relation to HIV-1 incidence of KS increases by a factor of 20,000 to 50,000 times with the presence of HHV-8.
It is postulated that HIV-1 infections promote HHV-8 replication indirectly by suppression of host immune systems. KS is thought to begin with micro-vascular lesions mediated by different environmental factors for each of the four categories of KS. One of these factors is abnormal cytokine production; in HIV-1 associated KS, this includes an increase in inflammatory cytokines, such as IFN , TNF , and IL-7 that are enhanced by Tat of HIV-1. Tat which is essential for HIV-1 replication is released and taken up by other cells, where it inhibits T-cell proliferation and promotes abnormal cytokine production, adhesion, and growth.
Nonetheless, the damage caused to special proteins (which control the optimal division and growth of cells) may play a critical role in the development of Hodgkin 's Lymphoma (Eichenauer, Engert, & Dreyling, 2011). In the same vein, Kaplan (2012) has indicated that patients with HIV and AIDS have increasingly susceptible to Hodgkin 's Lymphoma. The higher risk of HIV and AIDS patients to Hodgkin’s Lymphoma has not decreased even with the success of combination antiretroviral therapy (cART) in contemporary medicine. Furthermore, patients that use immune suppressants are also at increased risk of developing Hodgkin 's Lymphoma (Engert & Horning,
Chester M. Southam, MD, was an American virologist who worked on curing cancer. “Studies had shown that a pathogen called the Russian spring-summer encephalitis virus could eradicate tumors in mice. Because that virus was considered too dangerous for people, Southam searched for something milder, settling on the newly discovered West Nile virus.” He had already spent some time in Africa injecting an assortment of viruses including mumps, dengue, West Nile, and Semliki Forest virus in severely ill cancer patients. The West Nile Virus usually
Kaposi Sarcoma is a cancer that develops from the cells that line lymph or blood vessels. This type of cancer usually appears as tumors on the skin or on mucosal surfaces such as inside the mouth, they also appear in the lymph nodes, the lungs, or digestive tract. The skin lesions of Kaposi sarcoma are normally on the legs or face, the lesions are usually purple, red, or brown blotches or tumors. KS can become life threatening when the lesions are in the lungs, liver, or digestive tract. If a patient has KS in their digestive tract then it can cause bleeding, but KS in the lungs can cause trouble in breathing. There are a couple different types of Kaposi Sarcoma including, Epidemic /AIDS-related KS, Classic Kaposi Sarcoma, African Kaposi Sarcoma,
2. The highest frequency of antibodies to this virus was found in Japan, yet no AIDS cases had been reported from that country;(4)
..., while a cell undergoes cell cycle, when a cell comes in contact with another cell, it stops reproducing. However, cancer cells continue to duplicate repeatedly until there is a mass of cells or a tumor to form (see figure 9). Lastly, in cell division when there is a mutation or abnormality in the DNA, a normal cell stops dividing. However, a cancerous cell will continue to duplicate and form mutations (“Cell Biology and Cancer”). Also, cancer cells are harmful because they grow and duplicate with complete disregard to the functions and limitations of the body (see figure 10). Also, cancerous cells have the ability to spread through metastasis throughout parts of the body through the bloodstream. In terms of similar behavior to that of normal cells, cancerous cells also duplicate, but at a very different rate ("Cancer Cells vs. Normal Cells: What's Different?").
Cancer starts when certain cells in the body are mutated or changed and begin to divide. Cancerous cells grow differently than normal cells, instead of progressing through the normal cell lifecycle, cancer cells continue to grow and create more abnormal cells. A specific trait of cancer cells is that they have the ability to infiltrate and grow into surrounding tissues, developing out of control and causing serious damage to the host (Vincent, 2008). Cells become cance...
Human behavior in the social environment presents a multidimensional composite of person, environment, and time. As per Hutchinson (2008), “Person, environment, and time interact dynamically. Relationships are reconfigured as the multiple influences of human behavior ebb and flow” (p. 9). An analysis of human behavior in the social environment concerns examining the biological, psychological, and spiritual person; as well as, environment, culture, dyads, families, and communities. This paper will serve as an analysis and comparison of two films through the lens of human behavior in the social environment. A biopsychosocial framework will be utilized to assess and determine optimal treatment interventions for a selected character of each film. Hutchinson (2008) describes a biopsychosocial approach, “In this approach, human behavior is considered to be a result of interactions of integrated biological, psychological, and social systems” (p.11). Additionally, Ericson’s stages of psychosocial developmental in relation to chosen characters from the films “Rachel is getting married” and “Mother and Child” will be discussed.
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S/S of HIV infection are often overlooked as normal signs of aging. During the first 2-4 weeks flu like symptoms may be noted, due to a large amount of the virus produced in the body. Other early stages of progression often missed, weight loss, skin rashes, fatigue, night sweats. Several infections may be noted, with the progression of weight loss, diarrhea and chronic illiness during the late stages of the disease (e.g. various forms of cancer are linked to HIV/AIDs disease) possibly due to one’s weakened immune system.
People infected with Human Immunodeficiency Virus (HIV) have a sequential destruction of CD4 T cells which always lead to a weakening of the immune system. Despite the reduction of CD4 T cells, the macrophages and dendritic cells are also affected by HIV. Moreover, HIV causes a dysfunctionality in B cells, CD8 T cells, and innate immune system cells (Shipley, 2013). For instance, the reduction of perforin production and IFN-γ secretion in CD8 T cells cannot help effector T cells to destruct virus-infected cells (Kuerten et al., 2008). The reduc...
Maturity is a coming of age when a person is growing emotionally and mentally. Maturity is gained by experiences and decision-making, thus learning from mistakes. This is evident in the novel To Kill a Mockingbird by Harper Lee. Through characterization and symbolism Lee displays maturity.
Acquired Immunodeficiency Syndrome (AIDS) first came to light in 1981. There has been a long and arduous global effort on the prevention of HIV/AIDS. HIV is a virus that is spread through body fluids that affect the specific T-cells of the immune system. Without treatment HIV infection leads to AIDS and there is no cure for AIDS. HIV infection can be controlled and the importance of primary pre...
Tumors are formed by the alteration of the body’s own cells. This can be caused by environmental factors such as radiation, like UV exposure, chemicals or viruses 1. These can disrupt genes that control growth and cause an increase in cell division and proliferation. Proto-oncogenes are those genes that control normal but essential cell processes that keep cell growth and death in check. Two important categories are apoptosis genes, which regulate cell death, and tumor suppressor genes, which decrease cell propagation 1 . If these genes were mutated to the point where they cannot produce a functioning protein, cell division would continue far past what it was supposed to and unhealthy cells would be allowed to live and continue to multiply. This is what creates a malignant tumor. Certain conditions in the body can also promote the growth of cancer cells. One of these is a deficiency of natural killer (NK) cells, which are able to kill cancer cells by creating a pore in the cell membrane with perforin and releasing granzymes into the cell. Low levels of perforin allow for tumor growth 1. Chronic inflammation can also ...