Rabies
Rabies virus belongs to the Lyssavirus family in which all the members are animal viruses mainly found in bats and are of a bullet-like shape. The virus is usually spread through bites or scratches. Rabies was first suspected in bats in Brazil during the 1910s. In 1931, it was diagnosed for the first time in Trinidad. Rabies is most common in Asia and found more in wild animals than in domestic animals or humans. There has only been one person who miraculously survived rabies even though she had never been previously exposed to it.
Rabies virus belongs to the order Mononegavirales, and within this group, it falls into the Rhabdoviridae family because of its shape. This family includes three genera of animal viruses: Lyssavirus, Ephemerovirus, and Vesiculovirus. The genus Lyssavirus includes the rabies virus and other viruses that are mainly found in bats.
The Rabies virus has a distinct bullet-like shape. The length of the virus structure is of about 180 nm with a cross-sectional diameter of about 75nm. Like a bullet, one end of the virus is rounded and the other end is planar or concave.
The genome encodes 5-proteins: nucleoprotein (N), phosphoprotein (P), matrix protein (M), glycoprotein (G), and polymerase (L). The two major structural components of viruses like rabies that fall under the rhabdoviruses family are: a helical ribonucleoprotein core (RNP) and a surrounding envelope. Rabies is an RNA virus. The arrangements of the five proteins and the RNA genome determine the structure of the rabies virus. The genome is a single-stranded, non-segmented, RNA of about 12kb that is followed by the five proteins.
The rabies virus is usually spread through bites or scratches, abrasions, or through open wounds in the skin when saliva (and in certain conditions, the urine) from an infected animal that makes contact with the open flesh. The virus-induced, aggressive biting-behavior in the infected animal, along with the viral budding into the salivary glands, maximize the chances of viral infection to a new host.
Rabies has been around for many years causing the deaths of animals as well as humans. During the 1910s, rabies in bats was suspected in Brazil. In 1931, it was definitively diagnosed for the first time in Trinidad in Latin America. Since 1985, bats have been the main rabies reservoirs identified. Bats are, and
have been, the number one source of infection for the cases diagnosed in domestic animals every year.
Recently in 2001, forty-nine U.S.
[1, 4, 5, 9, 13] There have been no documented cases where a human has contracted the disease from another human. [4] It appears, based on field and lab data, that infection requires direct contact with the virus through means such as contact with infective bodily secretions, urine, or tissues. [12] It is unknown to scientists how the virus can be maintained in the bat populations and avoids extinction as the host species becomes immune to its presence. [14] The incubation period from time of infection to the onset of symptoms is about 5-14 days in experimentally induced animals [4] and 8-14 days in natural field cases.
Rabies is a deadly virus that occurs in the brain. It can affect all mammals but the ones that are most commonly found with the virus are dogs, bats, raccoons, skunks, and coyotes. This means that any non-mammal can not contract the virus, such as fish, birds, and reptiles (2). The virus can be contracted by humans with saliva transfer with broken skin contact from an animal which has the disease. As this is the most common form of transferring the disease it is very believable that Tea Cake contracts the virus from the wild dog that “managed to bite [him] high up on his cheek bone once” (1). The rabies virus works by being a bullet shaped virus that directly attacks th...
Almost 2,000 died the night of the 1928 storm in Florida. Their Eyes Were Watching God by Zora Neale Hurston realistically depicts the Okeechobee hurricane that struck the coast of South Florida. The incredulous, category four storm produced winds as high as 150 mph and flood waters of up to eight feet. Hurston describes their heart wrenching experience throughout the end of the novel when Janie, the protagonist of the story, survives the devastating hurricane with her husband, Tea Cake. The book shows similarities between the overflow of Lake Okeechobee and the specific weather conditions of the hurricane, but differs regarding the aftermath of the storm.
...h apparently did not prevent transmission of T. equigenitalis (Erdman et al., 2011). With the exception of one, all other stallions were infected with T. equigenitalis indirectly via handling or contaminated fomites at breeding or collection facilities (Erdman et al., 2011). According to Erdman et al. (2011), this outbreak saw the largest number of horses that tested positive for the disease since the first outbreak in 1978. The source of the outbreak was most likely determined to be a stallion imported from Denmark in 2000 that had not been detected positive for T. equigenitalis neither upon pre-import testing in the country of origin nor quarantine testing in the United States (Erdman et al., 2011). The importation of this stallion in the United States subsequently led to subsequent transmission of infection between the years 2004 and 2009 (Erdman et al., 2011).
Cytomegalovirus (CMV) is the most common virus in the United States that can infect almost any individual. Cytomegalovirus is also referred to as Herpesvirus-5, which belongs to a branch of Herpesviridae family. Herpesviridae has a spherical shape that contains four significant elements that are important to the viron. The four elements are the core, tegument, capsid and the envelope. Alphaherpesvirinae, Betaherpesvirinae and Gammaherpesvirinae are three subfamilies which belong to Herpesviridae. Cytomegalovirus belongs to the Betaherpesvirinae family, which also include Muromegalovirus and Roseolovirus. The Alphaherpesvirinae subfamily includes Simplexvirus, Varicellovirus, Mardivirus and Iltovirus genera. The Gammaherpesvirinae subfamily contains Lymphocryptovirus and Rhadinovirus genera. The diameter size of the virus is based on each specific family; however, the core remains the same throughout the species, which contains single layer of double stranded DNA tightly condensed in the capsid. In the tegument component, there are 30 or more viral proteins that are shapeless that encompass the capsid. Out of the four major components, the tegument has the most poorly defined structure. On the other hand, the capsid is a well-defined structure that is an icosahedron, which is composed of 162 capsomeres, 12 of which are pentons and 150 are hexons (1). Last but not least, the liquid envelope surrounds the tegument with approximately 10 glycoprotein and cellular proteins. Each subfamily under the herpesviriade has its own arrangement between the liquid envelop and the tegument layer.
We need to understand the structure of the virus, the viral genome, and how it causes the disease, and also to better understand the body’s immune response to the infection. Hepatitis B is a hepadnavirus, (slectron emicroscopy image), with a 42 nm virion. The virion is a double shelled spherical particle and consists of smaller rods and spheres each with an average 22 nm diameter. Not surprisingly the virus is very resistant and survives in high temperatures and is known to have been sequenced from 400 year old mummified
The virus is primarily spherical shaped and roughly 200nm in size, surrounded by a host-cell derived membrane. Its genome is minus-sense single-stranded RNA 16-18 kb in length. It contains matrix protein inside the envelope, hemagglutinin and neuraminidase, fusion protein, nucleocapsid protein, and L and P proteins to form the RNA polymerase. The host-cell receptors on the outside are hemagglutinin and neuraminidase. The virus is allowed to enter the cell when the hemagglutinin/ neuraminidase glycoproteins fuse with the sialic acid on the surface of the host cell, and the capsid enters the cytoplasm. The infected cells express the fusion protein from the virus, and this links the host cells together to create syncitia.
Rabies does not discriminate against any warm blooded mammal; all that come into contact with the virus are at risk. Those who choose to live, work, and recreation in areas with a larger wildlife population are understandably at higher risk. People should be extremely wary of unknown animals and heed behavior changes in familiar animals. The virus is usually spread from a bite wound when the saliva of an infected animal is introduced to the victim via the bite. The virus travels from the origin of the wound to nerves and onward to ultimately infect the brain.
As the late 19th century progressed, technological ideas and inventions began to thrive. The notion that technology would impact life as we know it was an unbelievable idea to comprehend. People had no idea that something so simple such as the light bulb would become so vital to them and for century’s to come. Inventions such as, the typewriter, barbed wire, telephone, Kodak camera, and electric stove were created, however the major inventions created and use tremendously today are, Medicine, Electricity, and Transportation.
However, health concerned organizations want to ban the use of these products due to the increasing fears that they can cause harm to the consumers. For over 50 years, antibiotics have been added to the food of animals such as poultry, cattle and pigs. The main purpose for doing so is to lower the risk of disease in animals. Farm animals are housed together in overcrowded areas, which are very dirty. The hygiene level can get to such a poor state that they are often in contact with their own excreta as well as excreta of the other animals they are housed with and because of tight single air space they share, the likelihood of catching diseases from one another is further increased and very often a whole heard can be infected at one time.
Wear gloves and proper cloths if handling the infected animals to prevent the direct contact.
The purpose of this paper is to focus on a subject within my educational field that I can research and inform the public about. I plan to become a veterinarian .which would require my daily contact with humans and animals. Zoonotic diseases are risk factors that I have to be aware of in order to protect myself as well as my patients and their owners. Luckily developments in medicine have made it possible to cure zoonotic diseases and even prevent them from ever being contracted.
It is said that there is 20 species around the world but there are 4 most common species that cause the disease in humans a few are known as:
It is estimated that over one-half of the antibiotics in the U.S. are used in food animal production. The overuse of antimicrobials in food animal production is an under-appreciated problem. In both human and veterinary medicine, the risk of developing resistance rises each time bacteria are exposed to antimicrobials. Resistance opens the door to treatment failure for even the most common pathogens and leads to an increasing number of infections. The mounting evidence of the relationship between antimicrobial use in animal husbandry and the increase in bacterial resistance in humans has prompted several reviews of agricultural practices by scientific authorities in a number of countries, including the US.