Pka Drug Testing

The title of this article is specific enough on what information they are looking for when they are testing the drugs. However, they do not specify what the drugs are that they are testing and leave the reader guessing at one glance at the title. I assume one of the drugs is ibuprofen, because that was one of the keywords in my search for an article. The title is not overly long and is rather concise, which may have been their reasoning for leaving out the drugs of choice. The abstract indicates the five drugs they are testing, as well as giving the method for which they test the pKa values, and the data they received from the experiment. They also indicate how they measure the equilibrium mole fraction solubilities of each of their solvents. However, their abstract is quite long and goes into some detail on how they evaluated their data as though it was part of a discussion section (the abstract is 205 words). They also give abbreviations for things they have not defined in the abstract itself, so someone who is not familiar with these terms would be left clueless unless they look it up.

They also go to lengths to express previous work that has been done on determining water solubility and models developed to be used for proteins, nucleic acids, and other biochemical molecules. The introduction, however, is also quite long much like the abstract. They take their time explaining the effects that influence solubility and pKa that they could have just assumed were common knowledge to the reader. A lot of the introduction is explaining the methods that they will be using to test for the wanted data and the science behind how the methods work. I feel as though they should have explained their methods more thoroughly in the experimental section rather than in the