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History of pharmacology
"examination of pharmacogenomics
"examination of pharmacogenomics
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Personalized medicine is a swiftly evolving way of healthcare that customizes treatment to an individuals genetic make-up. This custom analyzes the molecular profile of each patient to determine a personalized diagnosis and course of treatment. The study of how genetic variations interface with drug response and disease risk is called pharmacogenomics (Genetic Science Learning Center, 2011). This revolutionary breakthrough in healthcare will soon become a leading practice for future generations to come.
For ages clinicians have been using the same trial and error approach to treating patients. Once a specific course of treatment was identified to cure a disease, that remedy became the standard by which to follow. But clinicians are realizing that new biological advances can be applied to the clinical approach of diagnosing patients. These clinicians are gaining knowledge of the molecular core of diseases and using this knowledge to apply genetic technology to patient care.
Understanding the role of genetics is crucial to the advancement of personalized medicine. Genetic information (genes) consist of a specific chain of bases. They are small pieces of DNA that code for all the proteins in a cell (McGraw-Hill 2009). DNA is the genetic make-up of an organism. This genetic information is a passed to a mRNA molecule. A mRNA is DNA’s messenger that translates gene expression into protein synthesis. This process is just one of many steps in the chain of bases. To use genetics as a way to diagnose and treat patients, clinicians must first understand the cause of gene mutations that lead to a lot of illnesses.
Gene mutation is a change in the specific chain of bases within a gene. A gene can mutate due to errors in dup...
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...e Therapy? Retrieved on May 14, 2011 from
http://ghr.nlm.nih.gov/handbook/therapy/genetherapy
Genetic Science Learning Center (2011, January 24) Personalized Medicine (Pharmacogenetics). Learn.Genetics. Retrieved May 14, 2011, from http://learn.genetics.utah.edu/content/health/pharma/
McGraw-Hill Learning Solutions (2009), Essentials of Biology
The Jackson Library (2011) What is Personalized Medicine? , Retrieved on May 14, 2011 from
http://genetichealth.jax.org/personalized-medicine/what-is/index.html
United Mitochondrial Disease Foundation, What is Mitochondrial Disease?, Retrieved May 14, 2011 from http://www.umdf.org/site/c.otJVJ7MMIqE/b.5692879/k.3851/What_is_Mitochondrial_Disease.htm
Pollack, A. (2008), Patient’s DNA May Be Signal To Tailor Medication, Retrieved on May 14, 2011 from http://www.nytimes.com/2008/12/30/business/30gene.html
It helps medics to find a direct genetic cause of the patient’s condition and target it with pharmaceutical or other therapies. The technology is used for the identification of DNA sequences that increase risks of current diseases and disorders; with this information carriers can start to make efforts to prevent them before the development of the problem. The video mentioned 200 actionable genes, structures that have direct links with a specific condition. Knowing about their presence, people have a chance to bring in preventive measures like taking anticoagulants in the case of identification of a thrombogenic gene. The technology led to the significant improvement of diagnostics and personalized treatments. It helped to find a rare, life-threatening mutation in case of Beery twins and assign a drug to a girl (Alexis) that returned her to a normal life. In the case of cancer genome sequencing led to the development of genetic drags, which target essential tumor genes and make malign structures to shrink. The video mentioned a product that works with the BRАF protein that induces cells to uncontrolled division; the drug led to the remission in the patient with metastasizing melanoma. Such treatment was effective in the case of cystic fibrosis. In the case of the breast cancer the technology helps to evaluate the aggressiveness of the condition and make a personalized decision about chemotherapy. The video also mentioned the pre-implantation genetic diagnosis – an early-staged technology that prevents the development of inherited disorders in
A permanent change in the DNA sequence which makes up a gene is what is referred to as gene mutation (Mahoney & Springer 2009). It is believed that gene mutation occurs in two ways: that is, it can be acquired in personal lifetime or inherited from a parent. Those that are passed from parents to the child are referred to as hereditary mutation. They acquire the name since they are present in the eggs and sperms or the germ cell. In this case, such kind of mutation is present all through one’s life in almost every cell in the body. A similarity in mutation and gene diversity is the change in the DNA sequence which makes both mutation and genetic diversity have related issues.
In conclusion, it is important for nurses to have proper training and information in the area of genetics and genomics so that it can be used in daily clinical practice (Thompson & Brooks, 2011). Using this information with clients and conducting a detailed genetic nursing assessment is a valuable component of being an effective health care provider and can help clients recognize, prevent, and/or treat diseases that are unique to their particular
In 1990, the first great stride of genetics took place. This was called the Human Genome Project, a large-scale operation that was designed to understand the human genome (genetic structure). Since its commencement, there have been many leaps and bounds that have taken place. For certain genetic issues that we once knew nothing about, we no...
Genetics can predetermine many things for an individual but health and prevention can aid in the prevention of the expression of some genes. This is why it is important for healthcare providers to promote their patient’s awareness of what he or she is at risk for so that they can live the healthiest life possible. It is much easier to prevent a disease than it is to cure one. As healthcare providers it is our responsibility to cure illnesses, sure, but more importantly it is our responsibility to prevent disease and increase our patient’s quality of
More recently it has evolved to mean “modifications” to DNA that affect gene expression but do not involve base changes
Race can be used as a way to link a person to their ancestry, which can lead doctors to critical information that can give their patient the best treatment they can. With all of the advances in medicine there is still no way to determine a patient’s specific genetics and be able to treat each person with respect to their unique genes. Doctors narrow down possible risk factors and medication interactions by categorizing patients, by gender, age, and race. Race is a general way f...
The American Cancer Society publishes current advances made in cancer research on their website. Many of the exciting discoveries about how best to treat the disease focus on the genetic aspects associated with certain types of cancer. In addition, treatments aimed at genetic solutions to cancer may be more effective and may cause fewer adverse side effects than traditional cancer treatments (American Can...
In April 2003, researchers successfully completed the Human Genome Project, more than two years ahead of schedule. The Human Genome Project has already led to the discovery of more than 1,800 genes that cause disease (“NIH Fact Sheets…”). As a result of the Human Genome Project, researchers can find a gene suspected of causing an inherited disease in a matter of days, rather than the years it would have taken before. “One major step was the development of the HapMap. The HapMap is a catalog of common genetic differences in the human genome. The HapMap has accelerated the search for genes that have a say in common human disease, and have already produced results in finding genetic factors involved in conditions ranging from age-related blindness to obesity”(NIH Fact Sheet). The Can...
As previously stated, there are several ways that these changes can occur, but the ones I will be focusing on are changes occurring to methyl and acetyl groups. The mechanism of heritability in animals is information coded into genes. Genes are wrapped around histones in the nucleus. When methyl groups attach to these histones, it winds the genes tighter, and since the shape is altered, it also alters the protein the gene codes for. Generally speaking, when you add a methyl group onto the histones, or "spool" of the gene, it makes it harder to code that gene’s proteins, just like if you got something stuck in the chain on your bike and tried to pedal it. The more methyl groups that build up, the worse the problem becomes. However, in most of the cases acetylation unwinds some of the histones, activating or reactivating a gene. Scientists are explo...
Since its inception, gene therapy has captured the attention of the public and ethics disciplines as a therapeutic application of human genetic engineering. The latter, in particular, has lead to concerns about germline modification and questions about the distinction between therapy and enhancement. The development of the gene therapy field and its progress to the clinic has not been without controversy. Although initially considered as a promising approach for treating the genetic of disease, the field has attracted disappointment for failing to fulfil its potential. With the resolution of many of the barriers that restricted the progress of gene therapy and increasing reports of clinical success, it is now generally recognised that earlier expectations may have been premature.
The scientific and medical progress of DNA as been emense, from involving the identification of our genes that trigger major diseases or the creation and manufacture of drugs to treat these diseases. DNA has many significant uses to society, health and culture of today. One important area of DNA research is that used for genetic and medical research. Our abi...
Another area of medical advancement is genetic engineering. Genetic engineering will detect and possibly stop diseases before birth. Many diseases are associated with specific genes that can be checked for disease and replaced if dysfunctional. Genetic testing has already revealed genetic mutations that cause hypertension, heart disease, diabetes, osteoporosis, colon cancer, polycystic kidney disease, Alzheimers disease, and others. (5) Replacing missing, altered, inactive, or dysfunctional genes will prevent diseases or even death. Also, progression of a disease can be monitored, and
Genetics & Personalized Medicine. (2013). University of Ottawa Heart Institute. Retrieved on February 3, 2014 from: http://www.ottawaheart.ca/research_discovery/genetics-personalized-medicine.htm
Genes are made of DNA – the code of life (Gene Therapy- The Great Debate!). The changes in genes may cause serious problems, which we called genetic disorder. In theory, the only method to cure genetic disorders is gene therapy, which basically means the replacement of genes in order to correct the loss or change in people’s DNA. Although gene therapy gives patients with genetic disorders a permanent cure, it is controversial because it has safety and efficacy problems, and raises ethical issues.