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Modified from Rosenberg,Jennifer."How Alexander Fleming Discovered Penicillin
Medical advancement of penicillin essay
The Discovery of Antibiotics
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Penicillin: discovered by Alexander Fleming, helps treat a wide spectrum of infections that could potentially harm you. When penicillin was discovered, doctors finally had something that would completely cure their patients. Upon examining some colonies of Staphylococcus Aureus, Alexander Fleming noticed that a mold called Penicillium Notatum had grown in his petri dishes while he was on vacation. When Fleming put the dishes under the microscope, he found that the mold had stopped the growth of the Staphylococci. Fleming took a while longer to grow more of the mold to prove his findings he found that the mold inhabited the growth of bacteria, and that it could be used to fight infectious diseases. Alexander Fleming did not, however have the
The Factor of War in the Development of Penicillin The discovery, development and subsequent use of penicillin can be considered to be one of the most important breakthroughs in medical history. There were many factors, which were involved in the development of penicillin, and it could be argued that war was the most important, but other factors were also responsible. Alexander Fleming was working in London as a bacteriologist in 1928 when he noticed that a growth of a mould called penicillin produced a substance that actually killed the germs he was working on. He realised that this might be very important and a year later he wrote an article about his findings. However, Fleming did not have the facilities or the support to develop and test his idea that penicillin could fight infection, and he didn't develop it further.
Adegoke AA, Tom M, Okoh AI, Jacob S (2010) Studies on multiple antibiotic resistant bacterial isolated from surgical site infection. Scient Res. Essays 5:3876-81.
Fleming reasoned that the fact that it killed the bacteria in the lab, that it could also be used to kill bacteria in humans, but after attempting and failing to grow more penicillin, he eventually gave up on the idea.
My disease is Streptococcal pneumonia or pneumonia is caused by the pathogen Streptococcus pneumoniae. Streptococcus pneumoniae is present in human’s normal flora, which normally doesn’t cause any problems or diseases. Sometimes though when the numbers get too low it can cause diseases or upper respiratory tract problems or infections (Todar, 2008-2012). Pneumonia caused by this pathogen has four stages. The first one is where the lungs fill with fluid. The second stage causes neutrophils and red blood cells to come to the area which are attracted by the pathogen. The third stage has the neutrophils stuffed into the alveoli in the lungs causing little bacteria to be left over. The fourth stage of this disease the remaining residue in the lungs are take out by the macrophages. Aside from these steps pneumonia follows, if the disease should persist further, it can get into the blood causing a systemic reaction resulting in the whole body being affected (Ballough). Some signs and symptoms of this disease are, “fever, malaise, cough, pleuritic chest pain, purulent or blood-tinged sputum” (Henry, 2013). Streptococcal pneumonia is spread through person-to-person contact through aerosol droplets affecting the respiratory tract causing it to get into the human body (Henry, 2013).
Stewart, Philip S, (2001) states that antibiotics are elements that are used to kill, or hinder the multiplication and growth of organisms. Especially, these antibiotics are meant to control fungi and bacteria. In this case, the antibiotics that are used in killing bacteria are referred to as bactericidal, and the ones that are used to prevent the multiplication process are bacteriostatic. The primary microbes for antibiotics are bacteria and fungi. These microorganisms are crucial to facilitate the secretion of substances that kill harmful bacteria which confer competition for the limited available nutrients (Southern, P. J., &Berg, 1981).
The decade between 1920 and 1930 was a milestone for many health breakthroughs. The work that was done in the 1920’s had a major impact in increasing overall life expectancy. Penicillin and insulin are an easy fix for sore throats and diabetes, respectively.
18). Even though those diseases were not his goal to cure it still made penicillin revolutionary for the time being. Fleming now knew how to make penicillin and started to mass produce it. In the 1930s during the upgrading process of penicillin Fleming himself was cured of severe conjunctivitis. Then in the 1940s the fully developed penicillin was created. The creation of penicillin cured a wide variety of diseases, which led to the world excelling in growth, and penicillin improved the way of medicine at the time. The variety of diseases cured by penicillin made it a must have antibiotic. Penicillin was used to cure multiple diseases including syphilis, gonorrhea, tuberculosis, gangrene, pneumonia, diphtheria, and scarlet fever ( Common Antibiotics ). All the diseases have one thing in common, they all have the ability to spread, some faster than others. When a disease is discovered people tried to make a cure. When penicillin was made diseases that were thought to never have a cure were cured. People began to demand that penicillin be sold in local pharmacies. Penicillin was released to help people with the variety of diseases curable by
The purpose of this paper is to review and summarize an article concerning antibiotic resistance. The article chosen was “The role of healthcare strategies in controlling antibiotic resistance” by Ann-Marie Aziz (2013) published in British Journal of Nursing, Vol. 22 Issue 18. This article discusses essential components to understand how antibiotics work; different strains of bacteria; what antibiotic resistance means and consists of; antibiotic resistance when pertaining to the production of foods. Along with strategies that can be utilized in health care to help reduce antibiotic resistance. For example, prescribing adjustments, sampling and testing; committees and education for staff and patients.
If Alexander Fleming didn’t notice that there was something strange with the petri dish that contained Penicillium notatum, then the a big majority of people would not be alive today. Penicillin is antibiotic or group of antibiotics produced from specific blue molds. It can treat certain infections such as ear, throat, and skin infections, it can also be used to treat rheumatic fever and chorea, because of penicillin the death rate of people dying from these bacterial infections has incredibly decreased. Penicillin is one of the most important discoveries of medicine that has made an important impact because of how it changed the course of medicine, how it affected the World War 2, and how it changed the world globally.
Approximately one year ago in Kentucky, a man went to sleep thinking he might have caught a flu. The next day, he is rushed to the local hospital while coughing up chunks of lung tissue; within a few hours he experiences organ failure and lips into a coma. Over the next two days, two other patients come in with the same symptoms and die almost immediately. This epidemic that swept over this small area in Kentucky was an ultra resistant strain of staph infection known as MRSA, or methicillin-resistant Staphylococcus aureus (Eisler, 2013). MRSA and other species of resistant bacteria have arisen from the global overuse of antibiotics. Over the years, resistant strains of bacteria have become more and more difficult to fend of using common antibiotic treatments. If something is not done to stop antibiotic resistance, completely resistant strains of bacteria, which we will be unable to kill through use of antibiotics.
The Center for Disease Control (CDC) said, “Each year in the United States, at least two million people become infected with bacteria that are resistant to antibiotics and at least twenty-three thousand people die each year as a direct result of these infections.” (Threat Report 2013) Antibiotics were created to kill bacteria; since they were created, the bacteria have started to become resistant to the antibiotics. Antibiotic resistance is the ability of a microorganism to withstand the effects of an antibiotic. Because of this resistance, I believe that the use of antibiotics have been proven to be more harmful to human health than helpful.
Penicillin, derived from the mold Penicillium, is the first antibiotic to successfully treat bacterial infections on humans. It was accidentally discovered by scientist, Alexander Fleming. While Fleming was growing Staphylococcus, a serious and often deadly infection, in a dish, he noticed the bacteria had stopped growing after a mold found its way
Ampicillin disrupts the third and final stage of bacterial cell wall synthesis by binding specific penicillin-binding proteins (PBPs) that are inside the bacterial cell wall. Then facilitated by bacterial cell wall autolytic enzymes, cell lysis beings. Ampicillin is metabolized by Hydrolysis of the B-lactam ring to penicilloic acid. Microorganisms such as salmonella, Escherichia coli, campylobacter, shigella aquificae, thermotogae, chrysiogenetes, nitrospira, deferribacteres, other eubacteria, and other enteric bacteria are sensitive to Ampicillin. Treatment Dosage can range from 1 to 2g IM or IV every 4 to 6 hours to the maximum does of 12g per day. Microorganisms resistant to Ampicillin are penicillinase- producing bacteria (some strains of staphylococci), Pseudomonas aeruginosa, P. Vulgaris, Kiebsiella pneumonia, and Enerobacter aerogenes.
Alexander Fleming started the history of antibiotics in the 1920's with his discovery of penicillin.When penicillin was first discovered and used widely, it was touted as a wonder drug, and consequently was used as one.Though not necessarily harmful to the patient penicillin was used for much more infections than it was able to combat.Today the same practice is observed in the medical profession, however at this point it is due more to the detriment of an uneducated public.Studies have been carried out that show the huge over usage of antibiotics.In the seventies Soyka et al, concluded, "60% of physicians surveyed gave antibiotics for the treatment of the common cold."[3], and by common knowledge the common cold is a virus, something that cannot be treated by an antibiotic.Nyquist
The discovery of antibiotics is attributed to Alexander Fleming who discovered the first antibiotic to be commercially used (Penicillin) in approximately 1928. An antibiotic, also known as an antimicrobial, is a medication that is taken in order to either destroy or slow the growth rate of bacteria. Antibiotics are integral to the success of many medical practises, such as; surgical procedures, organ transplants, the treatment of cancer and the treatment of the critically ill. (Ramanan Laxminarayan, 2013)