Obstructive Sleep Apnea (OSA)

540 Words2 Pages

There is no consensus regarding the mechanism of manifestation of neurocognitive consequences associated with obstructive sleep apnea (OSA) and their definite underlying process is unknown. However, there are some findings and theories about it. In OSA, there are different levels of hypoxia which are associated with many factors such as obesity and etc.1 The hippocampus has a region (CA1) which is more vulnerable and sensitive to the hypoxia that leads to inflammatory response (COX-2, TNF-a),2 which can bring about endothelial dysfunctions,3 disturbances of cerebrovascular blood flow,3 and consequently neuronal cells death.3 In addition, it provokes oxidative stress and nitric oxide synthase (iNOS).2 Another finding is related to NDPH (subtype …show more content…

For example, OSA and hypoxia induce and increase chemoreceptor mediated reflex, and consequently, increase in vagal activity, which leads to bradycardia.5 However, there are versatile mechanisms contributed to the heart failure and arrhythmias associated with OSA, there is no consistent opinion regarding this matter. It

More about Obstructive Sleep Apnea (OSA)

Open Document