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Neurotransmitters and psilocybin chemistry
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Psilocybin mushrooms, more commonly known as “shrooms” or “magic mushrooms”, are a psychoactive drug that contains psychedelic compounds psilocybin and psilocin, which inhibit brain activity and ultimately create a euphoric experience for users. It is commonly noted that individuals who take this drug will experience hallucinations that vary in intensity, and visual effects that essentially dissolve boundaries between objects. Extensive research has been done by scientists and psychiatrists in hopes to discover ways this drug can be used medically. However, today it is listed as a Schedule 1 drug, which deems that psilobcyin mushrooms have high potential for abuse and no accepted medical treatment uses. Moving forward, professionals believe …show more content…
As previously mentioned, most people orally ingest the product or mushroom containing psilocybin in order to experience the euphoric state of mind. “Psilocybin (4-phosphoryloxy-N,N-dimethyltryptamine) is a substituted indolealkylamine and belongs to the group of hallucinogenic tryptamines (Maps).” Once this compound enters your body, it acts as an agonist and mimics the effects of serotonin neurotransmitters inhibiting the routine functions of our central nervous system. Studies have shown that about 50% of the C-labeled psilocybin is absorbed after oral ingestion, and is uniformly spread throughout the body. Approximately one half hour after taking the magic mushrooms, the individual’s blood plasma will show substantial levels of psilocybin. In order for psychological effects to occur, blood levels need to reach a minimum threshold that varies depending on the user of the drug. Tests have been conducted that conclude the medium dose of psilocybin is 12-20mg. On average if this dose is ingested, full effects will begin between 70 and 90 minutes and continue on for
Psilocybin (4phosphodimethyltryptamine or N, N dimethyltryptamine (DMT)) is a naturally occurring indoleamine hallucinogen and is metabolized to psilocin after ingestion (Umbricht, Koller, Vollenweider, Schmid, 2001). Psilocin is the active chemical in the plant and it is what causes hallucinations and other behavioral changes in the individual taking the substance. It is stated that psilocybin is used in research because it is short-acting, naturally occurring and draws less attention then other well-know hallucinogens (Strassman 1996). There are not many studies done with human subjects so the majority of data has been collected with animals (rats in particular). In many articles the effects, both neurological and behavioral are likened to the effects of the hallucinogen LSD.
During a visit to Mexico, Gordon Wasson, a mycologist, discovered the use of psilocybin mushroom in spiritual ceremonies by Indian tribes. Upon experiencing the spiritual and hallucinatory effects of the mushroom, Wasson returned to the area accompanied by an experienced mycologist, Roger Heim, who managed to cultivate the mushroom once in France and send samples of it to the scientist who had discovered lysergic acid, Albert Hoffman. From the mushrooms, Hoffman successfully isolated two compounds which he further named psilocybin and psilocin. Analogs of these compounds were further synthesized and were employed mainly for psychotherapeutic uses. Many tests on psilocybin were made at Harvard University in the early 1960’s. However, along with LSD, psilocybin became a scheduled substance in 1970, making it illegal. During this time, psilocybin mushrooms became a part of the psychedelic and hippy movement and were used for recreational and spiritual purposes. Research on psilocybin ended in the late 1980’s because of strict rules imposed by the government but recently scientist have started researching on this chemical once more.
The combined findings of these two studies demonstrated that LSD decreased serotonin turnover in the brain. It is now widely accepted that hallucinogen action is primarily located on receptor 5-HT2A. In a study done in 1955, scientists found that daily administration of LSD resulted in an almost complete loss of sensitivity to the drug after 4 days. It is now believed that this is a result of 5-HT2A receptor down-regulation (cited in Nichols, 2004). In a later study published in 1985, it was found that daily LSD administration selectively decreased 5- HT2 receptor density in rat brains (Nichols, 2004). Studies have shown that activation of 5-HT2A receptors increase inhibitory post-synaptic potentials.
Psilocybin Mushrooms or more commonly referred to as "Shrooms, Magic Mushrooms etc" have been used by many different cultures in varies ways. The early Mesoamericans used them for communion in religious and healing ceremonies. During the era of The Hippie Movement people experimented with Psilocybin for recreation and experience vivid "trips". Some today believe that the mysterious "Manna" that was spoken of in the Old Testament or the "Tree of Knowledge" was infact this particular fungus. Regardless of all this Psilocybin, this natural compound has a interesting effect on the human brain.
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2)Strassman, R. Human Hallucinogenic Drug Research: Regulatory, Clinical and Scientific Issues. Brain Res. 162. 1990.
Sessa, B. "Is It Time to Revisit the Role of Psychedelic Drugs in Enhancing Human
A largely debated topic in today's society is whether or not psychedelic drugs should be legalized for medicinal purposes and if they should, how this legalization would affect the communities in which they’re being prominently medicinally used. Although many scientists have argued that psychedelics pose a mental health risk, closer examination shows that communities would have a significantly lower depression rate if certain psychedelics were legalized. Now to fully understand how psychedelics could be beneficial or the opposite thereof, you’ll need to understand how they work and what they are. What a psychedelic drug is, the immediate effects, both mentally and physically, and how communities might benefit and function with the sudden use of these drugs.
Psychedelics have always been a controversial subject in the world of drugs because they have the ability to alter one’s perception of reality. L.S.D, MDMA, and psilocybin are three of the main types of psychedelics on the drug market, all three of which are listed as schedule 1 by the DEA. A schedule 1 drug is considered to have a high addiction risk, has no medical value whatsoever, and is illegal to have in your possession. A schedule 2 drug is considered to have the potential for both medical purposes, and abuse. A schedule 3 drug is considered safe for medical use and can only be prescribed by a doctor. I however, believe that psychedelics should be reconsidered for at least schedule 2 as studies have shown an increase in the use of psychedelics in psychotherapy and can even help the terminally ill come to terms with their own deaths.
One must look beyond the stereotypes that psychedelics have earned in the twentieth century, and also modern science, that presupposes that any thing that cannot be explained within its own contexts either does not exist or is but a fanciful idea. However, the realm of psychedelics is uncharted area, and when dealing with such experimental substances, such as these psychedelic agents, one must proceed with caution, as was mentioned earlier the agents are powerful tools and can be used with skill or reckless abandon, and therefore can yield positive responses or deadly consequences. If used with care psychedelics will allow many psychologists and patients to embark on a perhaps endless journey of self-discovery.
Some hallucinogens occur naturally in trees, vines, seeds, fungi and leaves. Others are made in laboratories by mixing different chemical substances. LSD or acid is one of the most common, well-known hallucinogens. Psilocin or Psilocybin mushrooms, Mescaline or Peyote, MDMA, Bufotenine, Morning Glory seeds, Jimson weed, PCP and DMT are less common psychedelics with effects similar to LSD. PCP and Ketamine are drugs with hallucinogenic properties. Some drugs, such as cannabis, can cause hallucinogen-like effects when used in high doses or in certain ways. Using hallucinogens is often called tripping. In its pure form LSD is a white, odorless powder. This pure form is very strong, so LSD is usually mixed with other things to make the dose large enough to take. LSD comes in the form as liquids, tablets, capsules or squares of gelatin or blotting paper. LSD use can have many effects. These may include sleeplessness, trembling, and raised heart rate, and blood pressure. LSD users may feel several emotions at once (including extreme terror), and their senses may seem to get crossed, giving the feeling of hearing colors and seeing sounds. Even a tiny speck of LSD can trigger these effects. Many LSD users have flashbacks; sudden repetitions of their LSD experiences, days or months after they stop using the drug.
In the history of mankind, the hallucinogens have probably been the most important of the narcotics. Their fantastic effects made the...
*As you walk into the Divination tower your eyes are drawn to a round table covered in felt. Over the felt there appears to be a dark cloth with a deck of cards. Professor ____ is standing by the table and beckons you closer. She motions for you to take a seat and when the last student arrives she turns and starts talking. She appears excited*
Nichols, D. E., & Chemel, B. R. (2011). LSD and the serotonin system's effects on human
3. Most users roll it into a cigarette called a "joint", or into a cigar called a "blunt". Users may also smoke it in a water pipe referred to as a "bong" or they can eat it by mixing it into different foods called "special food".