The Spirit Molecule (DMT): An Endogenous Psychoactive

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The Spirit Molecule (DMT): An Endogenous Psychoactive

"The feeling of doing DMT is as though one had been struck by noetic lightning. The ordinary world is almost instantaneously replaced, not only with a hallucination, but a hallucination whose alien character is its utter alienness. Nothing in this world can prepare one for the impressions that fill your mind when you enter the DMT sensorium."- McKenna.

N,N-dimethyltryptamine(DMT) is a psychoactive chemical in the tryptamine family, which causes intense visuals and strong psychedelic mental affects when smoked, injected, snorted, or when swallowed orally (with an MAOI such as haramaline). DMT was first synthesized in 1931, and demonstrated to be hallucinogenic in 1956. It has been shown to be present in many plant genera (Acacia, Anadenanthera, Mimosa, Piptadenia, Virola) and is a major component of several hallucinogenic snuffs (cohoba, parica, yopo). It is also present in the intoxicating beverage ayahuasca made from banisteriopsis caapi. This drink inspired much rock art and paintings drawn on the walls of native shelters in tribal Africa- what would be called 'psychedelic' art today (Bindal, 1983). The mechanism of action of DMT and related compounds is still a scientific mystery, however DMT has been identified as an endogenous psychadelic- it is a neurotransmitter found naturally in the human body and takes part in normal brain metabolism. Twenty-five years ago, Japanese scientists discovered that the brain actively transports DMT across the blood-brain barrier into its tissues. "I know of no other psychedelic drug that the brain treats with such eagerness," said one of the scientists. What intrigued me were the questions, how and why does DMT alter our percep...

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... in the action of hallucinogens has provided a focal point for new studies. Is there a prototypic classical hallucinogen? Until we have the answers to such questions, we continue to seek out the complex relationship between humans and psychoactives.

Works Cited:

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3)B.L. Jacobs. 1987. How Hallucinogenic Drugs Work. "American Scientist". 75:385-92.

4)M.C. Bindal, S.P. Gupta, and P. Singh. 1983. QSAR Studies on Hallucinogens. 'Chemical Reviews'. 83:633-49.

5)Groff, S. Realms of the Human Unconcious: Observations from LSD Research. Jeremy Tarcher Inc., LA. 1980, pp 87-99.

6)www.erowid.Org

7)http://www.drugabuse.gov/pdf/monographs/146.pdf

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