After Bryant Hatch lost his leg to MRSA, which is a contagious and antibiotic- resistant staph bacteria that leads to potentially dangerous infection, his son and son in law discover some useful information. Both his sons were interested in microbiology. Brad Berges was a virologist and Jacob Hatch was a senior molecular biology student at the time in BYU. MRSA is usually picked up in the hospital by already-immunocompromised people like Bryant Hatch, who has struggled with foot problems and surgeries due to his diabetes. MRSA grows together into clusters creating a biofilm that is resistant to penetration by most known antibiotics. MRSA secretes white blood cell killing molecules, neutralizes your antibodies and trigger your immune system …show more content…
into hyperdrive. The problem is MRSA is growing increasingly resistant to antibiotics, even to vancomycin, the current gold standard treatment for the bacteria. Berges put his focus on a class of viruses called bacteriophage, which replicate by infecting and killing bacteria. Bacteriophages work by using their long tails as syringes to inject their DNA into a bacterial cell destroying it and releasing thousands of new phage particles in return.
Antibiotics were no longer working so he thought bacteriophage could be the next solution. Unlike antibiotics they replicate, mutate and evolve. Petri dishes were used to grow “lawns” of MRSA from nasal swabs, athletic facilities and hospitals by Hatch and about a dozen other researchers. After a 3-year study was done they discovered 12 bacteriophages with MRSA killing potential, some of which had decontaminated more than 90 percent of MRSA-infected glass and fabrics. The bacteriophage even penetrated the biofilm, something that antibiotics can't do. I think its interesting that bacteriophages were discovered around 100 years ago, but quickly forgotten about in the U.S and other parts of the world after antibiotics were found due to the fact that they were easier to make. But now they are coming back as something to study and research and have lots of potential advantages that can arise if more research is conducted. Although this study did discover 12 bacteriophages that have the ability to rule out MRSA, much more research must be conducted before it could be used to treat
MRSA. Bacteriophages are captivating viruses because from what we know they are not harmful to humans, but infect only bacteria hence their name.
Methicillin-resistant Staphylococcus aureus is similar to regular hospital acquired MRSA in that it is resistant to cefazolin, and antibiotics similar to cefazolin. However, it differs from MRSA in that it doesn't display MRSA’s common risk factors, and is susceptible to other various antibiotics.
Addie Rerecich was an eleven and a half year of girl who was just as normal as any other kid her age. She played sports and was very social. All that changed one night when she woke up complaining of some pain in her hip. Her mother thought it was just a simple softball injury, so she gave her some ibuprofen and sent her back to bed. When the pain didn’t subside, she was taken to the hospital. Initially the doctors said she had symptoms of a virus. The next day she could breath well and they said she now had pneumonia. When at the hospital the disease specialist said Addie had “community-aquired” resistant staphylococcus MRSA from picking her scabs. This infection caused damage in her lungs and was so bad she was then put on ECMO, total life
After the end of the experiment the unknown 10 sample was Staphylococcus epidermidis. Came to this conclusion by first beginning with a Gram Stain test. By doing this test it would be easier to determine which route to take on the man made flow chart. Gram positive and gram negative bacteria have a set of different tests to help determine the unknown bacterium. Based on the different tests that were conducted in lab during the semester it was determined that the blood agar, MSA, and catalase test are used for gram positive bacteria while Macconkey, EMB, TSI, and citrate tests are used for gram negative bacteria. The results of the gram stain test were cocci and purple. This indicated that the unknown bacteria were gram positive. The gram stain test eliminated Escherichia coli, Klebsiella pneumonia, Salmonella enterica, and Yersinia enterocolitica as choices because these bacteria are gram negative. Next a Blood Agar plate was used because in order to do a MSA or a Catalase test there needs to be a colony of the bacteria. The result of the Blood Agar plate was nonhemolytic. This indicated that there was no lysis of red blood cells. By looking at the plate there was no change in the medium. Next an MSA test was done and the results showed that there was growth but no color change. This illustrates that the unkown bacteria could tolerate high salt concentration but not ferment mannitol. The MSA plate eliminated Streptococcus pneumonia and Streptococcus pyogenes as choices since the bacteria can’t grow in high salt concentration. Staphylococcus aureus could be eliminated because not only did the unknown bacteria grow but also it didn’t change color to yellow. Lastly a Catalase test was done by taking a colony from the Blood Agar plate...
The Factor of War in the Development of Penicillin The discovery, development and subsequent use of penicillin can be considered to be one of the most important breakthroughs in medical history. There were many factors, which were involved in the development of penicillin, and it could be argued that war was the most important, but other factors were also responsible. Alexander Fleming was working in London as a bacteriologist in 1928 when he noticed that a growth of a mould called penicillin produced a substance that actually killed the germs he was working on. He realised that this might be very important and a year later he wrote an article about his findings. However, Fleming did not have the facilities or the support to develop and test his idea that penicillin could fight infection, and he didn't develop it further.
A remarkable breakthrough in medicine occurred in the late 1800s through the work of Louis Pasteur. Pasteur's experiments showed that bacteria reproduce like other living things and travel from place to place. Using the results of his findings, he developed pasteurization, which is the process of heating liquids to kill bacteria and prevent fermentation. He also produced an anthrax vaccine as well as a way to weaken the rabies virus. After studying Pasteur's work, Joseph Lister developed antisepsis, which is the process of killing disease-causing germs. In 1865 before an operation, he cleansed a leg wound first with carbolic acid, and performed the surgery with sterilized (by heat) instruments. The wound healed, and the patient survived. Prior to surgery, the patient would've needed an amputation. However, by incorporating these antiseptic procedures in all of his surgeries, he decreased postoperative deaths. The use of antiseptics eventually helped reduce bacterial infection not only in surgery but also in childbirth and in the treatment of battle wounds. Another man that made discoveries that reinforced those of Pasteur's was Robert Koch. Robert Koch isolated the germ that causes tuberculosis, identified the germ responsible for Asiatic cholera, and developed sanitary measures to prevent disease. (1)
In the documentary, Hunting the Nightmare Bacteria, reporter David Hoffman investigates this new untreatable infection along two individuals and a bacterial virus within a hospital. The first individual Hoffman investigates is Addie Rerecich of Arizona, she was treated for a staph infection with antibiotics, but other complications arise. Addie had a lung transplant, she was given several different antibiotics, but her body became pan-bacteria, non-resistance to the bacteria. Addie’s life was on the edge, she had to be on life support, and finally she received new lungs. The transplant helped Addie but it would take years before could go back to normal before the infection. The second individual is David Ricci; he had his leg amputated in India after a train accident. The antibiotic treatment he received became toxic to his body increasing problems. While in India, he underwent surgery almost every day because of infections he was developing. Back in Seattle, doctors found the NDM-1 resistance gene in his body; NDM-1 gene is resistance to almost all antib...
Biological evolution is defined as any genetic change in a population that is inherited over several, successive generations. (R.Bailey, 2014) The changes accumulate and over time a new species is created. One of the basic mechanisms of evolution is Natural Selection. Natural Selection is random genetic variation occurring within an organisms DNA and the beneficial mutations being preserved because they aid survival. (C.Darwin, 1859) Two notable scientists associated with the theory of evolution include Charles Darwin and Jean-Baptiste Lamarck.
Fleming reasoned that the fact that it killed the bacteria in the lab, that it could also be used to kill bacteria in humans, but after attempting and failing to grow more penicillin, he eventually gave up on the idea.
In one of the studies healthcare workers were provided a questionnaire only 27.3% responded that no other healthcare worker had ever talked to them about MRSA (Raupach-Rosin, et. al, 2016). This study proves that healthcare workers need to be more educated on the topic of MRSA, how it spreads to the patients, and how the intervention of infection control and patient education will assist in reducing the amount of MRSA cases acquired. In one study, patients underwent a MRSA screening for nasal colonization. Out of the 29,371 patients, 3,262 had MRSA colonization. (Marzec & Bessesen, 2016). The study conducted allowed healthcare providers to see the effects of how easily MRSA is spread and how many patients could easily contract
Life History and Characteristics: Staphylococcus aureus is a gram positive bacterium that is usually found in the nasal passages and on the skin of 15 to 40% of healthy humans, but can also survive in a wide variety of locations in the body. This bacterium is spread from person to person or to fomite by direct contact. Colonies of S. aureus appear in pairs, chains, or clusters. S. aureus is not an organism that is contained to one region of the world and is a universal health concern, specifically in the food handling industries.
Patient education is of paramount importance if MRSA is to be reduced to its lowest minimum. According to Noble 2009, patient’s education stands a critical component of managing MRSA therefore; nurses are expected to be prompt in educating patients on specific measures in limiting and reducing the spread of MRSA by person to person contact. (Noble, 2009) The specific measures includes definition of MRSA, mode of transmission, the damage it can do to the body, specific treatments available and the process of treatment. This is to help the patient take part in the care. Noble 2009 explains that during care giving nurses and all other healthcare provider involve in giving care to a patient should communicate to patient all the precaution that will prevent the transmission of MRSA, and also giving the scientific rationale for the use of any precaution that is been used in the cause of care giving. (Noble, 2009.)
MRSA is a major source of healthcare associated diseases, increased hospital mortality, and leading surgical site infection (Jennings, Bennett, Fisher, & Cook, 2014, p. 83). With the implementation of active surveillance screening and contact isolations program, an overall decrease in hospital associated MRSA infections has been observed (Jennings, Bennett, Fisher, & Cook, 2014, p. 83). The author of this paper will identify a theory that can be used to support the proposed intervention i.e., reduce the transmission of MRSA by active screening in patients at high-risk for MRSA on admission. This paper will then describe the selected theory, and rational for the selection, and how this theory will support the proposed solution and how to incorporate this theory in this project.
Infection control is very important in the health care profession. Health care professionals, who do not practice proper infection control, allow themselves to become susceptible to a number of infections. Among the most dreaded of these infections are: hepatitis B (HBV), hepatitis C (HCV), and human immunodeficiency virus (HIV). Another infection which has more recently increased in prevalence is methicillin-resistant Staphylococcus aureus (MRSA). These infections are all treated differently. Each infection has its own symptoms, classifications, and incubation periods. These infections are transmitted in very similar fashions, but they do not all target the same population.
At his Nobel Peace Prize speech in 1945, Alexander Fleming warned against the misuse of antibiotics and the fact that by doing this, one allows the bacteria to ‘become educated’ and therefore become resistant to the antibiotic. It is believed that the first cases of antibiotic resistance were shortly after this speech. (Fleming, 1945)