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Ischemic heart disease
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The ischemic heart disease (IHD), also known as coronary heart disease (CHD), occurs when the supply of the blood to the heart is interrupted due to the blockage of the coronary artery (Cooley, 2014). CHD is the most common type of heart disease and the leading cause of death in the United States (CDC, 2015) but what happens exactly in the IHD’s disease process? Anwar Jasib Thaaban (2015) stated that the inflammation and the oxidative stress might contribute to the pathology of the IHD. Oxidative stress occurs when there is an overproduction of the reactive oxygen species (ROS), which impairs the anti-oxidant defense system (Anwar Jasib Thaaban, 2015). It is fascinating to know how the IHD and polyphenols are interrelated. Polyphenols that
The primary concern for Mr. Miller would be preventing further ischemia and necrosis of the myocardial tissues, preventing serious complications such as cardiac dysrhythmias and heart failure, as well as relieving his chest pain that radiates to his left arm. Preventing further ischemia and necrosis of the myocardial tissue will help prevent the development of heart failure due to myocardial infarction, whereas relieving his pain will help reduce his episodes of shortness of breath, and will also help to reduce any anxiety and restlessness he may be having from being in pain and short of breath.
The gaseous free radical nitric oxide is an abundant intracellular messenger molecule that plays a central role in maintenance of health, and is heavily involved in signal transduction in various cells of the body [1]. This molecule acts as a mediator in the regulation of cardiac function as well as having an important role in regulating contractility of the heart and maintenance of vascular tone in the cardiovascular system. As one of the most significant individuals in our discovery of nitric oxide, Dr. Robert Furchgott pioneered our understanding of this molecule through his experiments on the vasorelaxant properties of acetylcholine and the subsequent proposal of the presence of the endothelium derived relaxing factor, which was later identified to be nitric oxide [7]. Given the observation that cardiovascular disorders are the number one cause of death in many nations around the world, research into the vasorelaxant properties seems particularly relevant in order to help combat rising rates of vascular hypertension and high blood pressure. In this paper, the properties of nitric oxide are discussed largely with respect to the cardiovascular system. This paper focuses on the synthesis and characteristics of nitric oxide, the mechanisms of action by which nitric oxide works and the regulation of nitric oxide in the body, and finally a short summary of Robert Furchgott’s contributions to the discovery of nitric oxide and its properties.
Atherosclerosis is a pathological condition that underlies several important adverse vascular events such as stroke, cerebrovascular disease, Coronary Artery Disease (CAD). etc. [1]. It is responsible for most of the cardiovascular morbidity and mortality in the Western World currently [2]. As a result of the adoption of the western life style, its prevalence is increasing all over the world and could likely reach epidemic status in the coming future [2]. Atherosclerosis is a chronic disease of the arterial wall whose underlying pathogenesis involves an imbalanced lipid metabolism and a maladaptive immune response involving chronic inflammation of the arterial wall [1]. Leukocyte trafficking shapes the disturbed equilibrium of lipid accumulation, immune responses and their clearance and homeostasis, and this leukocyte trafficking is governed by chemokines and their receptors [1]. Chemokines are a superfamily of small structurally related chemotactic cytokines, which are involved in leukocyte trafficking and activation [3]. Chemokines have been found to play major roles in selectively recruiting monocytes, neutrophils, and lymphocytes, as well as in inducing chemotaxis through the activation of G-protein-coupled receptors [4]. Additionally, chemokines and their receptors have been identified as key players in the progression of atherosclerosis, thus they are explored in order to find therapeutic targets to prevent or treat Atherosclerosis and by targeting the chemokine system various entry points for a causative treatment are offered [5]. In this essay, the role of chemokine system in atherosclerosis is visited, the strategies employed to target chemokines as a therapeutic pathway for atherosclerosis and clinical trials undertaken ...
Hegab Z, Gibbons S, Mamas M, et al. Role of advanced glycation end products in cardiovascular disease. World J Cardiol. 2012 Apr; 4 (4): 20-102.
CAD is a leading cause of morbidity and mortality throughout the worldwide. The prevalence of biological and metabolic risk factors were also found to be high in development of coronary artery disease. Patients with hypercholesterolemia are at increased risk to experience cardiovascular events and to die from vascular disease [2]. .Statins, among the most commonly prescribed drugs worldwide, are cholesterol let downing agents used to manage cardiovascular and coronary heart diseases and to treat hypercholesterolemia. Statin’s therapy ...
This assignment is a case study that aims to explore the biospychosocial impacts of a myocardial infarction on a service user. It will focus on the interventions used by healthcare professionals throughout the patient’s journey to recovery. To abide by the NMC’s code of conduct (2015) which states that all nurses owe a duty of confidentiality to all those who are receiving care, the service user used in this case study will be referred to as Julie. Julie is a 67 year old lady who was rushed to her local accident and emergency following an episode of acute chest pain and was suspected to have suffered from a myocardial infarction. Julie who lives alone reported she had been experiencing shortness of breath and
Cardiovascular disease is currently the leading cause of death in the United States. It is responsible for one in four deaths every year, about 600,000 mortalities. This disease affects men and women, as well as every ethnic group. Coronary artery disease is the most common cardiovascular disease, representing approximately 400,000 deaths per year of the aforementioned 600,000 total deaths from cardiovascular diseases as a whole. In 2010 alone, coronary artery disease cost the United States $108.9 billion for health care services, medication, and lost productivity. These chilling statistics, published every year by the American Medical Association, demonstrate the immediate need for new and innovative ways to prevent, detect, and treat coronary heart disease. This paper will explore the molecular biology behind the disease while explaining the current treatments and prevention that are available today, why they work and what can be done to improve them.
Phenolic acids are secondary plant metabolites widely distributed in foods, especially fruits and vegetables. In recent years, phenolic acids have attracted a lot of attention because they exist ubiquitously in plants and play protective roles. Phenolic acids possess interesting biological properties, (Beilin, Stocker, & Croft, 1997) that render them interesting to study. They are widespread in crops such as fruits, vegetables, herbs, grains, and seeds and derived foods such as juices, wines, and oils, (Graf, Ameho, Dolnokowski, Milbuty, Chen, & Blumberg, 2006). Phenolic compounds play a key role in thwarting the negative impacts of oxygen and nitrogen reactive species (ROS/RNS), maintaining the redox homeostasis of biological fluids and preventing conditions such as cardiovascular diseases, atherosclerosis, and other degenerative pathologies, such as cancer, diabetes, Alzheimer’s and Parkinson’s diseases, (Shahrzad & Bitsch, 1998).
Dietary Factors in Preventing Heart Disease As coronary heart disease is the leading cause of death in the UK, more attention should be paid to preventing the disease. Many patients suffering from heart disease realise that it was mainly caused by their diet. Research has shown that elevated levels of LDL cholesterol are associated with increased risk of heart disease. “ Studies indicate that for every 1% elevation in the bad cholesterol there is a 2% increase in risk of heart disease” (A leaflet on heart disease.)
Oxidative stress is critical as it is extensively related to human diseases, such as rheumatoid arthritis, Alzheimer’s, Parkinson’s, diabetes, cataract, aging and cancer (Zhao and Zha...
Coronary artery disease (CAD) is the number one killer in America, affecting more than 13 million people. CAD occurs when a fatty substance called plaque builds up in the coronary arteries. These arteries disperse oxygen-ric...
What methods does Sheriff use to encourage you to feel sympathy for Raleigh at different points in the play? Journey’s End, the play written by Sherriff during post-World War 1, tells the story of a company, serving under the British empire in the north of France near the Belgium border, in the city of St Quentin. The setting of the play is March 28, 1918, towards the end of the war. The playwright wishes to portray his message of antiwar through this play. By telling the story of Jimmy Raleigh and his tragic experience through war.
Atherosclerosis begins when the inner wall of the artery becomes damaged and cholesterol and fatty plaques begin to lodge in the arteries. Damage to the endothelial wall inside the artery can be caused by hypertension, hyperlipidemia, and hyperglycemia (“Subclinical Atherosclerosis..” 443). When this happens, the immune system responds by sending monocytes to the damaged area. The monocytes turn into macrophages; their job is to eat up the excess cholesterol and unblock the artery. The macrophages are unable to digest all of the cholesterol, and as a result turn in to foam cells. When many macrophages are turned into foam cells, plaque results, and protrudes into the arterial wall, restricting blood flow and raising blood pressure (“Atherosclerosis Growth Process.” 8). If the plaque becomes too large it may break, releasing plaque into the blood. This can cause a great reduction in blood flow or a clot, resulting in stroke or myocardial infarction (“Stroke Risk.” 3).
Oxidative stress results from an imbalance in oxidant production and antioxidant defense mechanisms; this means that either the overproduction of reactive oxygen and nitrogen species (ROS/RNS) and / or a decreased antioxidant capacity leads to
Generally, antioxidants can be divided into natural and synthetic antioxidants. Natural antioxidants are normally found in the plant extracts which are believed to exhibit strong antioxidant activity and protection against oxidant-induced damage such as diabetes, neurodegenerative and cardiovascular disease (Maganha et al. 2010). Plants, fruits and vegetables are all known to be rich sources of natural antioxidants due to the presence of phenolic compounds, which are the secondary metabolites in plants (Misan 2010; Arya and Yadav 2011). Polyphenols, or phenolic compounds, constitute one of the most numerous and widely-distributed groups of substances in the plant kingdom (Urquiaga and Leighton 2000; Gan et al. 2010). They exist naturally in the form of glycosylated which makes them the most common water-soluble antioxidant compounds present in plants ...