Intrinsa is a testosterone transdermal patch for treating hypoactive sexual desire disease (HSDD) in surgically menopausal women. The women whose ovaries are removed surgically experiences 50% reduction in serum testosterone level leading to HSDD. Symptoms of this disease are absence of sexual thoughts, less sexual desire and activity, developing personal distress and mental tension.
Intrinsa is a transdermal matrix patch which is used to maintain the testosterone level in body fluid required in case of surgically menopausal women receiving concomitant estrogen therapy. It delivers constant low dose of the hormone systematically into serum avoiding first pass hepatic metabolism. Although before its approval it was tested for its pharmacology,
efficacy, toxicology & safety, but these studies were performed on the specific population only i.e. surgically menopausal women Intrinsa was not approved by the FDA (Food & Drug Administration) while on the other hand was approved by EMEA (European medical agency). EMEA suggests that the product has more benefit over its adverse effects and safety issues, as HSDD is a critical diseased condition and intrinsa effectively treat the diseased condition. While, FDA not approved the same product for the market besides its benefit. According to the FDA Procter & Gamble (manufacturer of the Intrinsa) performed Clinical studies on the special population of women whose ovaries are surgically removed and were concomitantly treated with estrogen. In these types of population levels of testosterone hormone is less and the product is effective; but no data was being generated for the healthy population. FDA also cited concerns regarding intrinsa’s use over long time, as no long-time safety data was also being generated. Intrinsa may be useful to treat HSDD and it is more beneficiary over its adverse effects, but as its clinical studies are only being performed over special population and not on the healthy population and also no long-term safety studies are being performed, it may cause severe adverse effects to the patient. Generating clinical data before marketing of the product is an important step towards product development. It is helpful tool to check whether the product having desired effect is also safe. Since, no safety studies and insufficient human trials are being performed on the intrinsa it should not be marketed before performing the reqired studies.
LJI308 is a potent and selective inhibitor of RSK. The p90 ribosomal S6 kinase (RSK) comprises a family of serine/threonine kinase which is expressed in various human cancers. RSK is the cytosolic substrate for the ERK (extracellular sianal-regulated kinase), involved in direct regulation of cell survival, proliferation, and cell polarity. Previous studies have demonstrated that RSK pathway is important for the growth and proliferation of cancer stem cells [1,2].
The first step is to pre-register the patient's insurance information into the computer system and making a copy of their insurance cards. The patient's insurance information would then be verified. The patient would then be seen by a medical professional to examine the patient, discuss any test results or provide a diagnosis. Once the patient is ready to check out any payment due would be collected. The medical coder would then go over the patients' medical record and assign any diagnosis codes or procedural codes and then a claim form (CMS 1500) would be completed and submitted. The payment would also receive and posted at this time and document in the patient's record. The CMS 1500 will information from the patient, including the type of
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According to what I read in the textbook, the CMS 1500 form is divided in two considerable parts: 1- Patient and Insured Information, which you can find in locators 1 through 13; and 2- Physician or Supplier Information, which you can find in locators 14 through 33. But this form can be divided in three sections as well: 1-Demography (from locators 1 through 13), 2- Procedural and diagnostic information (from locators 14 through 24) and 3- The technical part (from locators 25 through 33).
Sildenafil Citrate, more commonly known by the brand name Viagra, has become one of the most commonly prescribed drugs in America. Viagra is used to treat erectile dysfunction, also known as impotence. Erectile Dysfunction is best defined as the inability to maintain an erection necessary for sexual satisfaction. Sildenafil has been shown to be effective for a "broad range ED patients, including those with a history of mellitus, depression, … hypertension, diabetes, …and spinal chord injury" (Sildenafil Citrate, par. 29).
To Kill a Mockingbird, the novel by Harper Lee embodies a work of Southern literature, set in the 1930s in a small town in Alabama. The book’s genre exemplifies a coming-of-age historical fiction story. The narrator, a young girl named Scout Finch, describes the lessons she and her brother Jem learn when their father, a lawyer named Atticus, defends an African American man who stands accused of raping a white woman. The novel’s premise revolves around the efforts of a father raising his children and guiding them in their moral development. Along the way, the book deals with the themes of courage, prejudice and maturity. These three concepts are defined differently by Atticus than by most of the other people in the town where he lives. According to Atticus, courage means doing what remains as right and resisting what remains as wrong, even if other people oppose you. In contrast to the prejudice of the townspeople, Atticus believes it important to treat everyone equally. Maturity, in Atticus’ view, refers to having a sense of conscience and seeking to protect those who remain innocent. As these definitions show, Atticus Finch displays a strong sense of ethics. His goal as a parent remains to pass his values on to his children. This paper will argue that Scout and Jem learn the true meanings of courage, prejudice and maturity through the influence of their father and the example he sets for them.
There is no doubt that the particular layout of space of the 1893 World’s Columbian Exposition reflected the gender inequalities that existed within American society at the time. In particular, the Women’s Building offered a microcosm of the prejudices that dominated the overall landscape of the 1893 World’s Columbian Exposition. Although the men who organized the Columbian Exposition were unable to exclude women’s achievements altogether from the exposition, they were successful in relegating them into a bounded unit that overwhelmingly categorized their contributions as different and marginal, framing womanliness as “soft,” “delicate,” and “refined.” Discussions of the Women’s Building’s architectural aesthetics highlights such gendered dimensions of the Columbian Exposition quite clearly.
The symbolism and imagery used in the short stories paints a vivid picture into the author’s train of thought. Charlotte Perkins Gilman and Shirley Jackson were not normal writers. The stories are a form of gothic writing. This paper will be analyzing the point of view, symbolism, and setting in the stories The Yellow Wallpaper by Charlotte Perkins Gilman, and The Lottery by Shirley Jackson.
In my opinion this method is only good for men that do not want to be the biological father of any children in the future. Men who are sensative to surgery should think hard before they proceed with this.
At the point when a women’s body quits creating estrogen, it can cause numerous awkward side effects. A few of the transient manifestations include; hot flashes, temperament changes, unpredictable periods, vaginal or urinary tract diseases, urinary incontinence, aggravation of the vagina, rest issue, or diminished sexual want (Cooper). There are likewise long-term manifestations in which a woman may persevere through, for example, an expanded danger of coronary illness and osteoporosis (Hempel, Md.). Even though these indications may appear to be awkward and appear just as they could disturb a women’s social, expert, and individual life there are options that a woman can use to ease these side effects. The one noteworthy choice for woman is Hormone Replacement Therapy (HRT). HRT can be a positive alternative for women who need to experience this phase of their lives without enduring inconvenience; in any case, HRT can likewise cause some real medical
I believe that I, Christine Kuykendall, am a good candidate for a spot in National Junior Honors Society. I hold all of the core values, I am an all A student, and I love helping in the community. I am also a very hard worker and I believe that I can do great things in National Junior Honors Society.
Describe what AIS is and mechanism of Androgenic Insensitivity Syndrome. Explain the hormonal mechanism underlying the development of these symptoms. Discuss how these condition relates to typical sex development.
Would you say that majority of the American population believe that people who grew up and were raised in a less than desirable setting are less educated and least likely to succeed in life? Or would you say that these same people are more likely to succeed in life because of there ability to adapt and utilize not only their educational background but also their mental routine. To often has society posed to be bias and has delivered judgment without truly knowing the true definition of the word intelligence.
Rapkin, Andrea J., Michelle McDonald, and Sharon A. Winer. "Ethinyl estradiol/drospirenone for the Treatment of the Emotional and Physical Symptoms of Premenstrual Dysphoric Disorder." Women's Health 3.4 (2007): 395-408. ProQuest. Web. 25 Feb. 2014.
The Impasse Ronsin, a dilapidated Parisian alley tucked away behind the Montparnasse and near the entrance of a hospital morgue, has long been the stuff of legends for both art historians and fans of Dada and Surrealism. Notorious for a double murder involving the mistress of the President Félix Faure in 1908, the alley was seized upon soon after as the perfect studio space and home for artists such as Constantin Brancusi, William N. Copley, Max Ernst, Yves Klein, Les Lalanne, Larry Rivers and many other important artists of the early 20th century. Nikki de Saint Phalle made her famous shooting paintings there, Jean Tinguely and Yves Klein collaborated on “Excavatrice de l’Espace”; Marcel Duchamp and Man Ray were daily fixtures hatching avant-garde