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Biochemistry of regulation of blood sugar
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Insulin therapy promotes movement of water and electrolytes such as magnesium, phosphate and potassium, and facilitates intracellular transport of glucose from the blood into adipose tissues and muscle (Bryant & Knights 2015). Mostly, glucose is extracted from carbohydrates, which is the energy source for body cells. Insulin allows that the glucose reaches to the cells, so body organs like the liver, heart, brain and muscle are able to take up glucose to fuel their own energy need (Tham et al. 2017). This movement of glucose into the body cells reduces glucose level in the blood. Glucose in Tony’s body is excessive, the kidneys release excess glucose through urine to protect the body. This is why Tony often felt thirst to compensate the loss …show more content…
2018). It is recommended to be measured at least every 3 months when glycaemic targets are not being met and when diabetes therapy is being adjusted or changed. However, testing at 6-month intervals may be considered in situations where glycaemic targets are achieved consistently (Berard et al. 2018). Ideal HbA1c targets in type 1 diabetes are <7.5% for children and adolescents. If one is not on medication and not having symptoms of hypoglycaemia and A1C is low, that means BGL is well controlled. However, Tony is on medications and have experienced episodes of hypoglycaemia. Therefore, A1C testing is needed, and with the result, Tony's doctor should adjust his medication (Berard et al. …show more content…
2018). It is recommended to perform at least three times a day including both pre-and postprandial measurements to achieve their goal for the glucose level management. In a large cohort study, the performance of more than 3 self-tests per day was associated with a statistically and clinically significant 1.0% absolute reduction in A1C (Berard et al. 2018). In situations where A1C does not accurately reflect glucose level, monitoring BG is necessary to adequately monitor glycaemia (Berard et al. 2018). The test involves pricking a finger with a lancet device to gain a small blood sample, applying a blood drop onto a testing strip, and determining the glucose concentration by inserting the strip into a reflectance photometer for an automated reading (Berman et al.
During the year 1889, two researchers, Joseph Von Mering and Oskar Minkowski, discovered the disease that is known today as diabetes. Diabetes is a disease in which the insulin levels (a hormone produced in unique cells called the islets of Langerhans found in the pancreas) in the bloodstream are irregular and therefore affect the way the body uses sugars, as well as other nutrients. Up until the 1920’s, it was known that being diagnosed with diabetes was a death sentence which usually affected “children and adults under 30.” Those who were diagnosed were usually very hungry and thirsty, which are two of the symptoms associated with diabetes. However, no matter how much they ate, their bodies wouldn’t be able to use the nutrients due to the lack of insulin.
The pathophysiology of diabetes mellitus in is related to the insulin hormone. Insulin is secreted by cells in the pancreas and is responsible for regulating the level of glucose in the bloodstream. It also aids the body in breaking down the glucose to be used as energy. When someone suffers from diabetes, however, the body does not break down the glucose in the blood as a result of abnormal insulin metabolism. When there are elevated levels of glucose in the blood, it is known as hyperglycemia. If the levels continue to remain high over an extended period of time, damage can be done to the kidneys, cardiovascular systems; you can get eye disorders, or even cause nerve damage. When the glucose levels are low in one’s body, it is called hypoglycemia. A person begins to feel very jittery, and possibly dizzy. If that occurs over a period of time, the person can possibly faint. Diabetes mellitus occurs in three different forms - type 1, type 2, and gestational.
Typically, an 8-hour fasting glucose s taken to diagnose diabetes. If the blood sugar is 126 or more and is accompanied by classic signs of diabetes, then diabetes is indicated. . (Wong, Hockenberry, Wilson, 2015) Unable to remember the diagnostic study from when LF was diagnosed, they were able to tell me the continued testing that they do currently. Child gets her blood sugar** checked continuously throughout the day and sometimes in the middle of the night in order to prevent of catch highs and lows. Every three months, the child goes to see her pediatrician in Peoria that specializes in Diabetes and gets labs** drawn. Other than that, the family noted no other testing or procedures done regarding the child’s Type I diabetes.
Diabetes is a disease in which a person’s body in unable to make or utilize insulin properly which affects blood sugar levels. Insulin is a hormone that is produced in the pancreas, which helps to regulate glucose (sugar) levels, break down carbohydrates and fats, and is essential to produce the body’s energy. The CDC (2013) offers reliable insight, summarized here, into the different types of diabetes, some causes, and health complications that may arise from the disease.
Inject insulin into the fat layer just under your skin. If the insulin is injected into the muscle, it gets absorbed into the blood stream too fast. You can inject insulin into your abdomen, outer upper arm, buttocks, hip, and the front and side of the thigh. Insulin is absorbed quickest when it is given in the abdomen. Use a different spot each time you give yourself an injection. This helps prevent changes to your skin such as lumps, swelling, or thickened skin. Avoid injecting insulin into areas where you have skin changes. The insulin may not be absorbed well in these areas.
The purpose of this study is to research the disease Type 2 Diabetes and to discover whether it is being effectively treated and prevented in Merced County, California. According to the National Institutes of Health, Diabetes Mellitus is “a lifelong (chronic) disease in which there are high levels of sugar (glucose) in the blood. It is also the most common form of Diabetes”.1 Furthermore, there are many risk and lifestyle factors associated with this disease, but the most prevalent are; obesity (#1 risk factor), sedentary lifestyle, unhealthy eating habits, family history and genetics, increased age, high blood pressure and high cholesterol, and a history of gestational diabetes.2 The long term complications of having type 2 diabetes can include but are not limited to; eye problems (cataracts and glaucoma), foot problems (neuropathy/ nerve damage), skin problems (infections), high blood pressure (which raises your risk for heart attack, stroke, eye problems and kidney disease), hearing loss, oral health, mental health and early death.3
...th. The test can be to check your blood glucose levels, cholesterol, triglycerides, lactic, and uric acid. And to check if your growing and checking for enlargements of the liver.
After the release of the GlucoGauge Monitors, the company began receiving troubling reports. Customers have been using social media to complain or address their issue and this, has affected the company in a negative way. Thereafter, we also have been receiving complaints from Doctors and patients about high inaccuracy rates on the GlucoGauge blood monitors. Physicians indicated that the inaccuracy readings were as high as 30% when the regular American Diabetes Association(ADA) approved devices are to exceed only exceed 10%. This high number of inaccuracy has hurt the company in a negative way and a solution must be found for it as quick as possible. Thus, I proposed the
Sliding scale therapy utilizes a set amount of carbohydrate allowed at each meal. A long-acting (or background) insulin dose is given as ordered no matter what the patient's blood sugar is. Short-acting insulin may be used as bolus insulin, which is given before meals and at bedtime. The bolus insulin dose is based upon the blood sugar level at the time of the dose. One common sliding scale regimen, among several, is a long-acting insulin want or twice daily, and a short-acting insulin before meals and at bedtime. Once a patient has received a short-acting insulin dose, it is imperative that the patient has a meal just as the "before meals" order indicates to avoid hypoglycemia. Inform the patient of their blood glucose level as this helps to keep the patient informed of how they tolerated what they have previously eaten. Verbally tell the patient what the injections are before administering to confirm correct medication and less than any chance of
... properly in relation to meals and in combination of other therapies will maintain tight glucose control. Great competency is shown by the client’s ability to verbally and visually demonstrate these skills and maintain the behavioral change six months or more with good quality of life. With that said, diabetes is a lifelong disease and requires lifelong management. Even the most compliant and competent client should be encouraged to follow-up on a regular basis to guarantee the best outcomes from living with diabetes.
When the blood glucose levels rise, insulin is released into the bloodstream by the islets of Langerhans (“How Does the Pancreas Work?”). The insulin is then able to transport sugar from the blood into the cells of the body, so that it can be converted into energy for the cells to use. Insulin can also keep the liver from producing more sugar, which has the effect of lowering blood sugar levels. When blood sugar levels are too low, the pancreas releases glucagon into the bloodstream, which acts as an antagonist to insulin, causing liver cells to release stored sugar and convert proteins into sugar to make them available as another source of energy (“How Does the Pancreas Work?”). The flow of glucagon is then stopped when blood glucose levels rise to a safe
Kirk, Julienne., Stegner, Jane., 2010. Journal of Diabetes Science and Technology: Self-Monitoring of Blood Glucose: Practical Aspects. Retrieved from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2864180/
Oral glucose tolerance test (OGTT) is a test used widely in clinical settings to analyse the release of insulin and insulin resistance in the body. However, since the sensitivity of insulin and insulin resistance is inter-dependent on each other, it is uncertain to what degree sensitivity of insulin and insulin resistance can be predicted (Stumovill et al. 2000). Oral glucose tolerance test (OGTT) is a measure of how the blood glucose is metabolised in the human body with the use of a sugar called ‘glucose’ which serves as an important source of energy to the body (Hillson, 2002). However, aside from the oral glucose tolerance test, there are other tests used for checking blood glucose levels and it includes: urinary dipstick and multistix.
For all types of diabetes, the first goal of MNT is to assist attain and maintain metabolic normality, this not only include blood glucose, but also lipid and lipoprotein levels.6-14 Even though, there is no known cure for diabetes type 1, the recommendations to get rid of their symptoms do not vary significantly, besides the use of medication. In fact, there are multiple studies that have found that nutritional therapy is an integral component for the treatment of diabetes by normalizing glucose levels, helping maintain weight, and avoiding complications such as other related health concerns.13-16 Recent research, especially on randomized clinical therapy shows that observing a good nutrition really works well in prevention than in the treatment of diabetes. In a study by Rossi and colleagues, 130 patients were randomized to compare a Diabetes Interactive Diary (DID) with standard carbohydrate counting in terms of metabolic and weight control. Of the 130 patients, 11 dropped out. However, they discover that DID is at least as effective as traditional carbohydrate counting education, allowing dietary freedom for a larger proportion of type 1 diabetic patients making it safe, requiring less time for education, and is associated with lower weight gain.14 Other studies have also demonstra...