Hyperlipidemia Research Paper

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Introduction:
Hyperlipidemia is a metabolic disorder characterized by elevated levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), Very LDLC (VLDL-C) and triglycerides (TGs) with a subsequent decrease in the levels of high-density lipoprotein cholesterol (HDL-C) in the systemic circulation.(1)Consumption of high fat or fructose diet, lifestyle modification,age, genetics, smoking, hypertension, type 2 diabetes and otherprecipitating factorsplay a significant role in causingaberrant lipid profile. Dyslipidemia is a major cause of atherosclerotic cardiovascular disease (ASCVDs), such as Coronary heart disease (CHD), ischemic cerebrovascular disease(CBVD) and peripheral vascular disease (PVD). (2)Cardiovascular diseases (CVDs) are the major leading cause of worldwide morbidity and mortality among the adults.A 20%reduction in blood cholesterol level can decrease about 31% of CHD incidence and 33% of its mortality rate. (3)
Hyperlipidemia is a primary target,to find a remedial measure forthe …show more content…

The first group ratsserve as normal control and received only 5% CMC(purified grade) orally. Theother four groupswere administered with a single intraperitonealinjection of a freshly prepared solution of Triton-WR 1339 (400 mg/kg),dissolved in normal saline to an overnight fasting (for 18hr) rats.After 72 hours of triton injection, respective treatments were given once daily to all the animals.Second and third groups serve as a positiveand standard control,received 5% CMC and atorvastatin (40mg/kg) respectively.Fourth and fifth grouprats,were supplemented with ethanolic and aqueous extractsof Cinnamon bark (CZEE and CZAE 500mg/kg of each) as shown in Table-1. Both the standard and cinnamon extracts were suspended in 5% CMC solution and were administered orally for seven days, after inducing hyperlipidemia.

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