Introduction:
Hyperlipidemia is a metabolic disorder characterized by elevated levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), Very LDLC (VLDL-C) and triglycerides (TGs) with a subsequent decrease in the levels of high-density lipoprotein cholesterol (HDL-C) in the systemic circulation.(1)Consumption of high fat or fructose diet, lifestyle modification,age, genetics, smoking, hypertension, type 2 diabetes and otherprecipitating factorsplay a significant role in causingaberrant lipid profile. Dyslipidemia is a major cause of atherosclerotic cardiovascular disease (ASCVDs), such as Coronary heart disease (CHD), ischemic cerebrovascular disease(CBVD) and peripheral vascular disease (PVD). (2)Cardiovascular diseases (CVDs) are the major leading cause of worldwide morbidity and mortality among the adults.A 20%reduction in blood cholesterol level can decrease about 31% of CHD incidence and 33% of its mortality rate. (3)
Hyperlipidemia is a primary target,to find a remedial measure forthe
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The first group ratsserve as normal control and received only 5% CMC(purified grade) orally. Theother four groupswere administered with a single intraperitonealinjection of a freshly prepared solution of Triton-WR 1339 (400 mg/kg),dissolved in normal saline to an overnight fasting (for 18hr) rats.After 72 hours of triton injection, respective treatments were given once daily to all the animals.Second and third groups serve as a positiveand standard control,received 5% CMC and atorvastatin (40mg/kg) respectively.Fourth and fifth grouprats,were supplemented with ethanolic and aqueous extractsof Cinnamon bark (CZEE and CZAE 500mg/kg of each) as shown in Table-1. Both the standard and cinnamon extracts were suspended in 5% CMC solution and were administered orally for seven days, after inducing hyperlipidemia.
Scheen AJ. Antidiabetic agents in subjects with mild dysglycaemia: Prevention or early treatment of type 2 diabetes. Diabetes and Metabolism. 2007;33:3-12.
Cinnamon is metabolized into sodium benzoate and eating cinnamon significantly elevates the level of sodium benzoate in your brain. Recent studies have shown that sodium benzoate helps with brain function and may prevent neurological disorders. It does this by creating a significant number of chemicals in the brain called neurotropic factors. These factors stimulate the birth of new neurons and encourage the survival of existing neurons. This greatly slows down degenerative diseases of the brain like Alzheimer’s and Parkinson’s.
Hyperplasia is the early stage development of cells to cancer cells. It increases in cells that have the capability to proliferate at a fast rate. Often times, hyperplasia is correlated with the increase in proliferation and the speed of mitosis. The increase in the number of cells with hyperplasia means that the proliferation is happening at a faster rate than normal. Hyperplasia is considered to be the early stage of dysplasia, though not all hyperplasia leads to dysplasia.
Lipid metabolism is one source of energy for the human body. We eat food containing one form of lipids, triacylglycerols. Before starting lipid metyabolism, these fats get broken down into droplets by bile salts.Triacylglycerols can be broken into fatty acids plus glycerol via hydrolysis with the help of the pancreatic lipase enzymen and then get used by cells for energy by breaking down even further. Once the pancreas and cells have enough energy and don’t need to absorb anymore, fatty acids get synthesized back into triacylgleryols. The excess triacylglycerols get stored in adipose tissue. Excess storage leads to weight gain and obesity.
operculum) was reduced to. In a study conducted by A.M. Quetin, electrolyte levels liver toxicity tests and blood sugar levels were shown to be
Almost everybody knows the negative effects bad cholesterol has on the body. Bad cholesterol has to do with low-density lipoprotein’s molecular transport deposits that thicken in the walls of the arteries hindering the flawless passage of blood affecting the atherogenic status of the arterial walls. But not everybody fully appreciates the important role cholesterol plays in the body. This non-soluble, waxy substance is essential to aid in the building of membranes, the manufacture of bile, strengthening of cell walls and nerve sheaths, and in the production of hormones.
St. John’s Wort, often called hypercium for its botanical name, Hypercium perforatum, is derived from a yellow flowering plant. Hypercium is native to Europe, western Asia, North Africa, Madeira and the Azores, and has been transported to and grows wild in parts of Australia and North America (Cracchiolo, 1999). Extracts of the plant have been used in European folk medicine for centuries (Kim, 1999), and in Germany today, Hypercium is used above all other antidepressants (Volz, 1997). Hypercium can be taken through infusion, powder, tincture, fluid extract, or oil, and because there is no standardization, doses range from 0.4mg to 2.7mg, and 300-1000mg of crude extract per day (www.frontiercoop.com/herbfest/98/notes/snjwort.html ).
Hypercholesterolemia is the presence of high levels of cholesterol in the blood. Cholesterol is a waxy fat-like substance and is a major class of lipid, so it gets into the blood by lipoproteins [1]. A high level of lipoproteins is unhealthy. A high level can result in an elevated risk of atherosclerosis and coronary heart disease [2]. The high levels of lipoproteins are often influenced by a combination of genetic and environmental factors such as obesity or dieting habits [2]. High cholesterol can be caused by mutations in the following genes: APOB, LDLR, LDLRAP1, and PCSK9 [3]. Mutations in the LDLR gene are responsible for causing familial hypercholesterolemia, which is the most commonly seen form of inherited high cholesterol [3]. The LDLR gene contains instructions for making LDL receptors or low-density lipoprotein receptors. LDL receptors play critical roles in regulating levels of cholesterol in the blood by removing low-density lipoproteins from the bloodstream. Mutations in the LDLR gene can make the amount of LDL receptors produced less than normal or affect their job of removing the low-density lipoproteins in the blood [4]. People who have these mutations will have higher levels of cholesterol. There are many ways that the environment can affect the levels of cholesterol in the blood. Reducing the amount of dietary fat you consume lowers the total amount of cholesterol in the blood [5]. Sucrose and fructose can raise the amount of LDL in the blood. Reducing fatty foods will however lower the amount of LDL [5]. Having a healthy body and maintaining physical exercise plays a key role in keeping your cholesterol at a healthy level. If you are overweight or obese you can lower your cholesterol levels by simply losing ...
CAD is a leading cause of morbidity and mortality throughout the worldwide. The prevalence of biological and metabolic risk factors were also found to be high in development of coronary artery disease. Patients with hypercholesterolemia are at increased risk to experience cardiovascular events and to die from vascular disease [2]. .Statins, among the most commonly prescribed drugs worldwide, are cholesterol let downing agents used to manage cardiovascular and coronary heart diseases and to treat hypercholesterolemia. Statin’s therapy ...
Tappy, L., Lê, K. A., Tran, C., & Paquot, N. (2010). Fructose and metabolic diseases: New findings,
Lipid altering drugs include several classes of medications each of which have their own mechanism of action. Statins inhibit HMG CoA reductase (hydroxymethylglutaryl CoA reductase), which is the rate-limiting enzyme for the production of cholesterol in the liver. Statins competitively inhibit this enzyme and induce an increased expression of LDL receptors in the liver. Which in turn increases the uptake catabolism of serum LDL into the liver resulting in decreased serum cholesterol level. This reduction in serum LDL and cholesterol levels has resulted in reduction of 10-year CHD and stroke risk. Pitavastatin was approved in Japan since 2003 and was granted FDA approval in 2009 and is marketed under the name of Livalo. Several phase III and IV trials have shown that Pitavastatin is both safe and efficacious in lowering both serum LDL and Triglycerides (TG) by 29.1% and 22.7% respectively from baseline levels which was significant. These studies showed that only 10% of Pitavastatin treated patients had adverse events (AE) in which 84% of these events were mild and about 1% were serious adverse events (SAE)6, 12, 14, 16-26, 28-31. Atorvastatin is the most commonly used statin in clinical practice; the F...
Metabolic syndrome is described to be a cluster of metabolic risk factors that combines together to create a single individual health issue. The individual factors that combined to create this issue are insulin resistance, hypertension which is a form of high blood pressure, cholesterol abnormalities, impaired glucose tolerance, the tendency to develop fat around the abdomen and an increased risk for clotting. The metabolic disorders and cardiovascular disease are very close related. This syndrome is considered to be a risk factor for several cardiovascular diseases and type 2 diabetes that arises due to insulin resistance and an abnormal function and pattern of body fat. Insulin resistance refers to the diminished ability of cells to respond to the action of insulin in promoting the transport of the sugar glucose, from blood into muscles and other tissues. Metabolic syndrome is also known as syndrome X or the dysmetabolic syndrome and people who are overweight or obese all fall at the highest risk for this syndrome. (Medicine.net, 1)
Henderson, L., Yue, Q. Y., Bergquist, C., Gerden, B., & Arlett, P. (2002). St John's wort (Hypericum perforatum): drug interactions and clinical outcomes. British journal of clinical pharmacology. 2002; 54(4):349-356.
Metabolic Syndrome (syndrome X, insulin resistance syndrome) is the name for a group of risk factors that raise your risk for diabetes mellitus (DM), cardiovascular disease (CVD), and other health problems, such as diabetes and stroke.2 It is characterized by abdominal obesity, insulin resistance, hypertension, low HDL, and elevated triglycerides. Some hallmarks of metabolic syndromes are dyslipidemia, central adiposity, and a predisposition to atherosclerotic cardiovascular disease, certain cancers, hypertension, and type 2 diabetes mellitus. Genetics appears to play an important role in predisposing certain individuals and populations to the development of metabolic syndrome.1 Multiple environmental factors modify this genetic predisposition and include physical inactivity, advancing age, cigarette smoking, and endocrine dysfunction. The presence of one or either of these signs should alert the clinician to search for other biochemical abnormalities that may be associated with the metabolic syndrome.
The tendency to build up high cholesterol may run in families, but extremely high levels are usually the result of a poor diet high in saturated fats and calories, along with little or no exercise. In some cases, high levels of cholesterol may be associated with undiagnosed medical symptoms such as diabetes or low thyroid function. According to the American Heart Association, there would eventually be a 50 percent lower rate of heart disease if Americans would lower their blood cholesterol levels by 25 percent. These statements find confirmation in a 1984 report done by the National Heart, Lung and Blood Institution on the results of a 10 year study. It showed that for every 1 percent of lowered cholesterol, the chances of a heart attack are lowered by 2 percent.