Histadine Decarboxylase Enzyme

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Sleep is regulated by the Superchiasmatic Nucleus (SCN). The SCN coordinates the bodies sleeping habits based on external environments. However, there are subsidiary regulating factors that also help the SCN regulate sleep. One of these factors is called the Histadine Decarboxylase enzyme (HDC). HDC regulates the release of Histamine a biochemical used to induce vigilance and prevent sleep. [1] Levels of sleep consistencies can be measured by the amount of Rapid-Eye Movement (REM) phases entered in one sleeping cycle. Therefore, by decreasing the level of activation of HDC will result in an increase of REM phases in one sleep cycle duration.
The model system used in this experiment is mice. A pharmacological approach will be taken to test

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