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Herpes Genitalis
Herpes simplex virus 2 research paper
Herpes simplex virus 2 research paper
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Herpes Simplex Virus is a highly contagious infection that is very common all over the world. HSV is commonly known has herpes and comes in two different forms, HSV-1 and HSV-2. HSV-1, also known as oral herpes, mainly spreads by mouth to mouth contact, which causes infections around the mouth and leads to painful sores. HSV-2, or genital herpes, is transmitted sexually. This causes infections in the genital or anal area. Although HSV-1 is frequently known for causing oral infections, it can also be transmitted to the genital area through oral sex. Majority of HSV-1 infections are acquired during childhood and although no symptoms may occur, the infection is lifelong. An estimated 3.7 billion people under age 50 have HSV-1 infection globally
(World Health Organization 2018). In people with compromised immune systems, HSV-1 can occur more frequently and lead to severe symptoms. Herpes in infants, or neonatal herpes occurs when a mother acquires HSV for the first time during pregnancy. The infant gets infected during childbirth due to contact with the genital tract. However, this is a very rare occurrence. Treatment for HSV-1 is mainly antiviral medications such as acyclovir, famciclovir, and valacyclovir. These medications help reduce the severity of the symptoms by stopping the spread of infection to other cells but this does not completely cure the infection. Since there has been no permanent cure, the inhibition of HSV-1 has been tackled using gene therapy. The reason for its reemergence after being latent is not fully understood as of yet, but evidence suggests viral RNA elements called LATS, or latency associated transcripts play a role (Stevens, J.G., et al, 1987). CRISPR-Cas9 (Clustered Regularly Interspaced Short Palindromic Repeats) is a genome editing tool that allows medical researches to edit parts of a genome by adding or removing parts of a DNA sequence. (cite) Cas 9 is an enzyme that cuts strands of DNA at a specific location so that DNA can be added or removed.
Bell’s palsy is a paralysis or weakness of the muscles on one side of your face. It results from damage to the nerve that controls movement of the muscles in the face, the damage may also affect your sense of taste and how you make tears and saliva. This condition can come on, often overnight and usually gets better on its own within a few weeks. This is not a result of a stroke or transient ischemic attack. This is referred to as a (TIA). Palsy simply means weakness or paralysis,
Most people in the U.S. learn STDs in their health class in high school. Syphilis is a sexually transmitted disease (STD) that causes sores over private parts or all over the body in a later stage. Syphilis is caused by a bacteria called spirochete. The spirochete cannot survive outside the body. The only way to get the disease is by intimate contact, but catching it is rare. Having more than one partner could increase the chances to catch the disease. The spirochete enters in a break in your skin genitals area or mouth. Once in your body, about three weeks it becomes a sore or have multiple sores. The sore looks like a crater on the surface of the skin. In the first stage it can be treated easily with antibiotics or penicillin. The second stage the syphilis spreads to the rest of the body. It is visible in your hand and soles on your feet. It can cause cardio-vascular disease, mental problems, paralysis, blindness and tumors. Syphilis has links to HIV/AIDS. It also attacks your nervous system. After infection it takes 21 to develop any symptoms for other people it takes from 10 to ninety days. It acts like no other disease known. The last stage is the deadliest if ignored, by the person. The damage obtained by syphilis is irreversible. By practicing safe sex (condoms), or having one sex partner can prevent these
Cytomegalovirus (CMV) is the most common virus in the United States that can infect almost any individual. Cytomegalovirus is also referred to as Herpesvirus-5, which belongs to a branch of Herpesviridae family. Herpesviridae has a spherical shape that contains four significant elements that are important to the viron. The four elements are the core, tegument, capsid and the envelope. Alphaherpesvirinae, Betaherpesvirinae and Gammaherpesvirinae are three subfamilies which belong to Herpesviridae. Cytomegalovirus belongs to the Betaherpesvirinae family, which also include Muromegalovirus and Roseolovirus. The Alphaherpesvirinae subfamily includes Simplexvirus, Varicellovirus, Mardivirus and Iltovirus genera. The Gammaherpesvirinae subfamily contains Lymphocryptovirus and Rhadinovirus genera. The diameter size of the virus is based on each specific family; however, the core remains the same throughout the species, which contains single layer of double stranded DNA tightly condensed in the capsid. In the tegument component, there are 30 or more viral proteins that are shapeless that encompass the capsid. Out of the four major components, the tegument has the most poorly defined structure. On the other hand, the capsid is a well-defined structure that is an icosahedron, which is composed of 162 capsomeres, 12 of which are pentons and 150 are hexons (1). Last but not least, the liquid envelope surrounds the tegument with approximately 10 glycoprotein and cellular proteins. Each subfamily under the herpesviriade has its own arrangement between the liquid envelop and the tegument layer.
and ears, and in the mouth and pharynx. The causative virus has been shown to be
Herpes Simplex is a common virus that causes infection in humans. This virus is spread in both humans and animals. However, humans are the primary reservoirs for HSV and are the only ones that experience any symptoms. There are two types of Herpes Simplex known as HSV-1 and HSV-2. HSV-1 primarily causes oral herpes while HSV-2 causes genital herpes.1 This virus is easily contracted and often during one’s childhood. Unfortunately, this virus is latent and reoccurs every so often, more so during times of stress. Herpes Simplex is a mild infection for most, however, this virus can lead to many serious complications.
RSV plays a major role in respiratory infection among the childhood population, especially infants and younger children. It is the leading viral agent respiratory tract disease worldwide, causing bronchiolitis and pneumonia in infants and young children. There are about 100,000 cases and 4,500 deaths yearly of RSV infections in the United States (1). Typically, all children are infected with RSV by age 2 to 3; however, the infections can reemerge up to 5 to 6 per year. RSV was first extracted from chimpanzees that were showing upper respiratory tract disease as an agent in 1956 (1). The chimpanzees had an upper respiratory tract illness in addition to coryza, runny nose, and malaise. The humans that interacted with these chimpanzees soon also had mild upper respiratory tract illness. A Long strain was recovered in children who suffered from bronchopneumonia while a Schneider strain was recovered from a patient with croup. Together, a group of scientists combined all these strains into a term called “respiratory syncytial virus” (3).
Mumps is a paramyxovirus that is closely related to the parainfluenza virus. Its symptoms were first described in the 5th century BC, and it was a very common childhood affliction until the last several decades. It was identified as a virus in 1934, and an effective vaccine was developed in 1967. Mumps is acquired by aerosol, necessitating close human interaction for spread. Human beings are the only known reservoir for mumps virus, and there is only one serotype.
Hepatitis is inflammation of the liver. There are currently five known viruses that cause can hepatitis (Microbiology, 10e). The hepatitis C virus (HCV) is transmitted through contact with the blood of an infected person; however, it is now more commonly spread among IV drug users that share needles. Healthcare workers are also at risk for contracting HCV, but with standard precautions, the risk is low. “Prior to 1992, some people acquired the HCV infection from transfusions of blood or blood products. Since 1992, all blood products have been screened for HCV, and cases of HCV due to blood transfusion now are extremely rare. HCV can be passed from mother to unborn child. Approximately 4 out of every 100 infants born to HCV-positive mothers become infected with the virus. A small number of cases are transmitted through sexual intercourse; however, the risk of transmission of HCV from an infected individual to a non-infected spouse or sexual partner without the use of condoms over a lifetime has been estimated to be between 1% and 4%. There have also been some outbreaks of HCV when instruments exposed to blood have been re-used without appropriate disinfection.” (Microbiology, 10e)
Pathogens are a type of microorganism that spreads viral and bacterial diseases. These diseases when present in human blood and body fluids are known as blood borne pathogens, and can spread from one person to another. (Worcester polytechnic institute) The most serious types of blood borne diseases are the hepatitis B virus (HBV) and hepatitis C virus (HCV), which can cause liver damage; and HIV (human immunodeficiency virus), which is responsible for causing AIDS (acquired immune deficiency syndrome). The blood borne pathogens can be spread when the blood or body fluids (semen, vaginal fluid, breast milk, and amniotic fluid) of an infected individual comes into contact with mucous membranes or an open sore or cut on the skin of another person. Mucus membranes are located in the eyes, nose, mouth, and other areas as well. ("Bloodborne pathogens: MedlinePlus Medical Encyclopedia") Two of the most common ways that pathogens are transmitted is through the exchange of fluids during sexual intercourse or by sharing infected IV needles. (Worcester polytechnic institute)
Young adolescents do not understand that genital herpes is highly contagious and can be passed without them knowing. There are two types of herpes viruses: “type-1 which usually causes cold sores on the lips and mouth, and type-2 which usually causes genital herpes (Wee 2).
Waking up in the middle of the night when sick is flat out frustrating for the adult. Waking up in the middle of the night to your three-year-old toddler not being able to breathe is flat out terrifying. Three thoughts seem to circulate in your brain as you rush into their room in the middle of the night. The first is: what it wrong with them? They seemed fine when you put them to bed hours ago. As you assess the big picture, your mind can’t help but wonder what to do for them or how to help them because you have no idea why they seem to have to trouble breathing. You attempt to try not to panic at the little lips that look like they might be turning blue while at the same time the thought of ambulance or driving to the emergency room flashes through your mind. This can be just one scenario to children who are stricken with a Respiratory syncytial viral infection.
A 2-year-old girl who attends daycare presents with three days of fussiness and 1 day of refusal to eat. A daycare worker notices a few vesicular lesions on the child’s tongue and fingers of both hands. Which one of the following is NOT a likely culprit of the child’s condition?
There are two main types of the herpes simplex virus, HSV 1 usually oral and HSV 2 usually genital. HSV 1 is an infection of the lips, mouth, or gums. It can cause small, painful blisters which are commonly referred to as cold sores or fever blisters. It is so common that 80% of the population has it. Although HSV 2 can be spread to the mouth by oral sex, it isn't as common. No one knows when the first HSV infections began. They date back to as early as Ancient Greece. Herpes is a Greek word meaning "to creep or crawl". It wasn't recognized as being transmitted from one individual to another until 1893. By the 1920's and 30's, research of the natural history of HSV found that it not only infects the skin, but the nervous system as well.
Viruses can be transmitted in many ways. Being in contact with an infected person will most likely transfer the virus. One can also obtain the virus through swallowing, inhaling, and unsafe sex. Poor hygiene and eating habits usually increase the risk of catching a viral infection. Contracting a viral infection is followed by adverse s...
Sexually Transmitted Diseases Sexually Transmitted Diseases STDs, a.k.a venereal diseases, infectious diseases passed from one person to another during sexual contact. STDs are the most common infections known. More than 12 million people in the United States, including 3 million teenagers, are infected with STDs every year. The United States has the highest STD rate in the world about one in ten Americans will contract an STD during his or her lifetime. People who do not know they are infected risk infecting their sexual partners and, in some cases, their unborn children. If left untreated, these diseases may cause pain or may destroy a woman's ability to have children. Some STDs can be cured with a single dose of antibiotics, but AIDS cannot be cured. Those most at risk for contracting STDs are people who have unprotected sex—without using a condom, people who have multiple partners, and people whose sex partners are drug users who share needles. Static’s show that Americans between the ages of 16 and 24 are most likely of catching STDs than older adults, because younger people usually have multiple sexual partners than an older person in a long-term relationship. Teenagers may be embarrassed to tell their sexual partners they are infected Teenagers may also be embarrassed or unable to seek medical attention for STDs. This means that they only more likely to pass the disease to other young people and have a greater risk of suffering the long-term consequences of untreated STDs. STDs are transmitted by infectious bacteria, viruses, parasites, fungi, and single-celled organisms called protozoa that live in warm, moist parts of the body, like the genital area, mouth, and throat. Most STDs are spread while having sex, but oral sex can also spread disease. Some STDs are passed from a mother to her child while pregnant, when the disease enters the baby's bloodstream, during childbirth as the baby passes through the birth canal, or after birth, when the baby drinks infected breast milk. AIDS can be transmitted by blood contact such as open wounds, between people who share infected needles or received through an injection of infected blood. Some people believe that STDs can be transmitted through shaking hands or other casual contact, or through contact with inanimate objects such as clothing or toilet seats, but they can’t. Chlamydeous, is from trachoma is bacterium, is the most commonly transmitted STD in the United States.