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Gene therapy and ethical issues
Gene therapy and ethical issues
Gene therapy and ethical issues
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The book talks about how upcoming trends in gene and cell therapy is meant for those who look for the valuable thread that runs through the arena of gene therapy, cell therapy, and tissue engineering, yet found other sources too specialized to undertake it. This book focuses on arming basic clinicians and scientists with this valuable thread so that they are better situated to tackle the weakening diseases currently plaguing mankind. The authors argue that gene and cell therapies are promising policies for managing acquired and genetic illnesses. Currently, various ethical issues and biological barriers have restricted their clinical interpretation. This book is important in informing the audience on the currently position of gene therapy especially to experts who are trying to ensure that gene therapy becomes successful. Being successful involves it being …show more content…
The Future of Gene Therapy. Biotechnol Healthc. 2005 Jun; 2(3): 52-54, 56-60. Retrieved from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564347/ This article talks about both the history and potential future of gene therapy. The author claims that in its present expression, gene therapy is a well-designed theory plainly executed. That is not a criticism but rather it’s current position in an extremely complicated technology which is still in its formative years. After all, only five years have passed since the invention of gene therapy was persuasively confirmed to provide, if not a cure, then, long term therapeutic impact for X-linked severe joint immunodeficiency disease. This article gives an insight on the current trends on gene therapy because it offers critical analysis of gene therapy both at the beginning to the current state. It also explores the position of patients who underwent gene therapy so as to ascertain whether this therapy has been successful or not. This helps in establishing the reason why this mode of therapy has been gaining slower acceptance than it initially
In this paper, I will argue that genetic therapies should be allowed for diseases and disabilities that cause individuals pain, shorter life spans, and noticeable disadvantages in life. I believe this because everyone deserves to have the most even starting place in life as possible. That is no being should be limited in their life due to diseases and disabilities that can be cured with genetic therapies. I will be basing my argument off the article by “Gene Therapies and the Pursuit of a Better Human” by Sara Goering. One objection to genetic therapies is that removing disabilities and diseases might cause humans to lose sympathy towards others and their fragility (332). However, I do not believe this because there are many other events and conditions in society that spark human compassion and sympathy towards others.
There have been four somewhat recent successful gene therapy treatments. The four deal with correcting hemophilia, bone marrow transplants, skin cancer, and vessel growth. In the success with the bone marrow transplants, French researchers collected bone marrow cells from patients, used gene therapy to correct the bone marrow, and then returned the bone marrow to the patient. This was 80% successful as reports 16 months after the transplants showed. Squamous cell carcinoma, skin cancer of the head and neck, was treated using gene therapy as well. The fourth trial was where DNA was used to carry a substance that stimulates blood vessel growth to damaged heart tissue and in this trial there was much success noted.
... fight the disease. It is crucial that regulation be a necessary component of gene therapy research and applications. In hopes that the government can regulate and can receive this treatment, not restricting it to people that has serious genetic diseases. Gene therapy will change the field of medicine from what it is today. As scientist discovers more genes and their functions, the potential of this treatment is limitless. Though gene therapy is an auspicious treatment choice for numerous diseases (including inherited disorders, some types of cancer, and certain viral infections), the procedure remains precarious and is still under study to make sure that it will be safe and effective. Thus government regulators and scientist must take a lead role in adopting a practical approach to address these issues and determining the correct procedures for dealing with them.
Just as there are different types of people who look at one glass of water and describe it as half full or half empty, the public has many different views on the future of our society. Gene therapy is also a glass that can be viewed in different angles – different perspectives. Some say it has great potential to shape the ideals of our future, while others believe it signifies intolerance for disabilities, imperfections that supposedly deplete from a person’s interests, opportunities and welfare (quoted by Peter Singer, xviii). This global issue has brought people with different opinions in the open, arguing their views using history, morality and foresight.
Human gene therapy is a method used in the medical field that treats diseases at a molecular level, by solving the source of the problem; our genes. Today, diseases and disorders are commonly treated by solving the symptoms, the surface of the problem. Many disorders and diseases are caused by defective proteins and within those defective proteins are damaged and defective genes. These defective genes can be treated through gene therapy. Gene therapy is not new and has been developed and improved by researchers for the past couple years. Being an experimental technique, gene therapy also has its pros and cons, but so far is showing positive and rising success rates.
Gene therapy is a technique which has developed in the wake of recombinant DNA (rDNA) technology. It is a process which results in the correction of a genetic disorder by the addition of a piece or fragment of DNA into the genetic material of a living, functioning cell. A mere thirty years ago this concept belonged to the realm of the human imagination made manifest in the works of science fiction. Today it belongs to the realm of the human imagination made manifest in the works of science, period. It is mind boggling to try to comprehend the far reaching effects of gene therapy. How is it affecting society? Who will benefit from its use? Should it be used at all? Should research continue? How do we answer all of these questions? The answers are not readily available, nor are they black and white, but an attempt at finding some solutions must be made. Before exploring this line of thought further, a basic understanding of the technical aspects of gene therapy is essential.
In September 14, 1990, an operation, which is called gene therapy, was performed successfully at the National Institutes of Health in the United States. The operation was only a temporary success because many problems have emerged since then. Gene therapy is a remedy that introduces genes to target cells and replaces defective genes in order to cure the diseases which cannot be cured by traditional medicines. Although gene therapy gives someone who is born with a genetic disease or who suffers cancer a permanent chance of being cured, it is high-risk and sometimes unethical because the failure rate is extremely high and issues like how “good” and “bad” uses of gene therapy can be distinguished still haven’t been answered satisfactorily.
Over 20 years after the proclamation of these specific ethical guidelines, we are introduced to the University of Pennsylvania’s Institute for Human Gene Therapy’s study on a delivery mechanism for gene therapy that resulted in the death of an 18 year old research subject Jesse Gelsinger. Gelsinger suffered from partial OTC (ornithine transcarbamylase) deficiency caused by a defective single gene (Obasogie, 2009).
"What's the worst that can happen to me? I die, and it's for the babies," said Jessie Gelsinger as he left for the hospital to receive gene therapy treatment. (Stolberg) People risk their lives everyday in the name of science. One such science that people have recently been drawn to is gene therapy. Although, gene therapy may be new and exciting and it may be helping to find cures to diseases we only dreamed of curing, we have to remember it is dangerous. It needs to be done with much supervision. Every new step we take in the advancement of gene therapy should be thought over because the consequences could reach farther then we ever believed they could. There are so many dangers of the techniques used that can lead to consequences as serious as death. The government imposes many guidelines, and it needs to stay that way. The biggest dangers, however, may be in what is to come.
As a result of the discussions, there should be an implementation of steps to guide decisions relating to genome engineering. The simplicity of CRISPR-Cas9 has “revolutionized the field of genetics and molecular biology” (par. 2) thus allowing anyone with a “knowledge of molecular biology to modify genomes” (par. 3). Before this technology became available, this was a very difficult or impossible task. For example, using CRISPR-Cas9 technology, it is now possible to replace mutated genes that underlie liver-based metabolic disease in mice. Stem cells can be cultured to produce specific tissues such as heart muscle cells or neurons. CRISPR-Cas9 technology can also replicate the genetic basis for human diseases, which gives scientists insights into previously difficult to comprehend disorders. Along with its potential to change the world of medicine, there is the potential that this new technology may have unintended effects and could create unknown risks to human health and well-being. The authors point out that even straightforward medical scenarios raise concern over the possibility of unintended consequences because there are limits to the scientist’s knowledge of genetics, gene-environment interactions and the pathways of disease. Also, some of these genetic changes are heritable, raising significant concern for problems that could be passed to the next generation. All of these scenarios and examples show the urgent need for establishing guidelines for the implementation of genome engineering. In order to keep public trust in science, there must be transparency and open discussion regarding all decisions. Implementing these guidelines and decisions early in the process will ensure that these new technologies will benefit
Since its inception, gene therapy has captured the attention of the public and ethics disciplines as a therapeutic application of human genetic engineering. The latter, in particular, has lead to concerns about germline modification and questions about the distinction between therapy and enhancement. The development of the gene therapy field and its progress to the clinic has not been without controversy. Although initially considered as a promising approach for treating the genetic of disease, the field has attracted disappointment for failing to fulfil its potential. With the resolution of many of the barriers that restricted the progress of gene therapy and increasing reports of clinical success, it is now generally recognised that earlier expectations may have been premature.
Safdar, M. (2010) Gene Therapy: Advantages and Disadvantages [Online] Available at: http://www.biotecharticles.com/Genetics-Article/Gene-Therapy-Advantages-and-Disadvantages-271.html [Accessed July 17 2011]
In an article titled “The Ethical Implications of Gene Therapy” the group of advisers on Ethical Implications of Biotechnology of the European commission states issues and rules that should be abided by, along with beliefs on the direction of biotechnology. At its present stage, biotechnology focuses on serious diseases which are incurable at the moment, however through this research treatment for these diseases could be found. The group of advisers feel that there should be levels at which research should focus on, instead of jumping into it all at once. Basic research should be carried out prior to clinical trials, and then move on to biotechnology. This can be done by supporting research actions, organizing training and exchange programs or any other appropriate means. Gene therapy protocols require that ethical evaluation consists of processes assuring quality, transparency and efficiency without delays of treatment to the patients who need it. This is crucial because an inefficient, poor quality treatment could cost someone their life. The group also feels that gene therapy research should be restricted to serious diseases for which there is not a current treatment. Expanding research to other things could be done if a medical evaluation calls for it. Equal access should be assured to all researchers within the European Union, thus sharing information and helping to improve orphan drugs. This could also save time and money. In order to insure the public of what is going on, conclusions of evaluations should regularly be published to encourage public debate. The public is not usually informed much about genetic therapy and many people have the wrong idea about it. Should reports be published more often, there will be less public confusion and ridicule.
In the end, gene therapy in humans needs to come a long way before it will be widely accepted, but there is great potential in the technology and it needs to be pursued. Bibliography Anderson, W. F. (1992). The Species of the World. Human Gene Therapy -. Science, 256 (5058), 808-813.
The American Medical Association lists cancer, AIDS, cystic fibrosis, Parkinson’s and Alzheimer’s diseases, amyotrophic lateral sclerosis (Lou Gehrig's disease), cardiovascular disease and arthritis, as established cures or possible cures using somatic gene therapy (“Gene” 1). The application for somatic gene therapy involves the repair or replacement of a defective gene with a corrected gene manipulated in a lab. The treatment affects only the targeted cells of the individual receiving treatment and, is isolated to the individual receiving treatment, meaning not passed on to subsequent generations. This application offers cures without impact on future generations, effectively making further germ-line engineering