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The most important complication encountered in persons affected by familial hypercholesterolemia is
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What is Familial hypercholesterolemia and how familial hypercholesterolemia can affect you a person? Familial hypercholesterolemia is an inherited condition that can lead to problem within your heart. This genetic disorder can cause high levels of low density lipoprotein (LDL) cholesterol levels that begins at birth and can led to a number of heart attacks for a person at a young age. We all need some cholesterol to work certain things in your body properly but if you have way too much cholesterol in your blood stream it will start to build up in the walls of the arteries and cause an increasing chance of you getting heart disease. If a person’s have familial hypercholesterolemia they have levels of LDL cholesterol which means that your liver
is suppose to remove the LDL out their bloodstream , but your liver is not removing the LDL like it is supposed to causing the person to have a high level of LDL cholesterol in their body. Since the person has a high level of LDL cholesterol they have a higher risk of having heart disease and heart attacks. Familial hypercholesterolemia is an inherited disorder and is an autosomal dominant manner. For a person to have this kind of disorder only of the the two person’s number 19 chromosome is affected. If a person is homozygous familial hypercholesterolemia they of have gotten both copies of the mutated genes from both of their parents.If this person has children they will be heterozygous familial hypercholesterolemia because their children will inherit one copy of the mutated gene.
Hyperlipidemia or increased cholesterol builds up causing narrowing in the arteries, which reduces oxygen rich blood flow to the heart and tissues, also increasing the risk for myocardial infarction. Obesity increases the risk of developing diabetes, high blood pressure, and hyperlipidemia, increasing the risk of atherosclerosis, and therefore increasing
Vicki is a 42-year-old African American woman who was diagnosed with Hypertension a month ago. She has been married to her high school sweetheart for the past 20 years. She is self-employed and runs a successful insurance agency. Her work requires frequent travel and Vicki often has to eat at fast food restaurants for most of her meals. A poor diet that is high in salt and fat and low in nutrients for the body and stress from her job are contributing factors of Vicki’s diagnosis of hypertension. This paper will discuss the diagnostic testing, Complementary and Alternative Medicine treatments, the prognosis for hypertension, appropriate treatment for Vicki, patient education, and potential barriers to therapy that Vicki may experience.
How does this history of high blood pressure demonstrate the problem description and etiology components of the P.E.R.I.E. process? What different types of studies were used to establish etiology or contributory cause?
There is a broad spectrum of crimes that are committed day to day. When one thinks of murder, parental murder against children is not at the forefront of the mind. Filicide, or the murder of one’s child, is a crime that is common but not mentioned often. About 500 filicide cases happen each year, which has been close to the same number for about a decade (Orenstein, Brown University, 2014). Also according to studies, boys were 58.3 percent more likely to be killed than girls. Looking at statistics from the National Institute of Health, as of 2004 in the US, 311 of 578 (53.8%) children under the age of five were murdered by their parents. From 1976 to 2004, maternal filicide accounted for 30 percent of all children under the age of five while
Nowadays, DNA is a crucial component of a crime scene investigation, used to both to identify perpetrators from crime scenes and to determine a suspect’s guilt or innocence (Butler, 2005). The method of constructing a distinctive “fingerprint” from an individual’s DNA was first described by Alec Jeffreys in 1985. He discovered regions of repetitions of nucleotides inherent in DNA strands that differed from person to person (now known as variable number of tandem repeats, or VNTRs), and developed a technique to adjust the length variation into a definitive identity marker (Butler, 2005). Since then, DNA fingerprinting has been refined to be an indispensible source of evidence, expanded into multiple methods befitting different types of DNA samples. One of the more controversial practices of DNA forensics is familial DNA searching, which takes partial, rather than exact, matches between crime scene DNA and DNA stored in a public database as possible leads for further examination and information about the suspect. Using familial DNA searching for investigative purposes is a reliable and advantageous method to convict criminals.
LDL or bad cholesterol comes from food that is a high source of cholesterol and/or saturated fats. Plaque forms when bad or LDL cholesterol builds up in your bloodstream and attaches to the arterial wall, as more LDL builds up the plaque becomes larger, this can become a major problem for your cardiovascular system. Because plaque is a substance that has rough edges, it reduces the elastic nature of the artery which means your heart will have to work double-time to pump the necessary blood to all your limbs, that will mean your limbs won’t get the amount of oxygen that they require to function properly. Plaque can also narrow the area blood has to pass through, this means your heart has to work overtime and overall capacity of your cardiovascular system is lowered. When the LDL cholesterol embeds itself in the wall of the artery it than damages the artery then blood pressure expands it which causes an aneurysm. When an aneurysm is too weak there is a high possibility of it bursting, when that happens it leaves the cells in and around that area without oxygen. If that artery is connected to a major vital organ the person will most likely die. When the blood flow is slowed it shows a greater risk for blood clots and although blood clots are natural and important to healing broken blood vessels, if blood clots gather inside the blood vessel this proves to be a serious health risk. The clots have the possibility to get stuck and completely cut off the blood flow to cells, leaving them without oxygen and causing them to die. If a clot gets inside a blood vessel connected to a major organ this could cause the person to die. The heart is fed by the coronary artery, if plaque or a blood clot blocks off blood flow to the heart, the heart ...
Hypercholesterolemia is the presence of high levels of cholesterol in the blood. Cholesterol is a waxy fat-like substance and is a major class of lipid, so it gets into the blood by lipoproteins [1]. A high level of lipoproteins is unhealthy. A high level can result in an elevated risk of atherosclerosis and coronary heart disease [2]. The high levels of lipoproteins are often influenced by a combination of genetic and environmental factors such as obesity or dieting habits [2]. High cholesterol can be caused by mutations in the following genes: APOB, LDLR, LDLRAP1, and PCSK9 [3]. Mutations in the LDLR gene are responsible for causing familial hypercholesterolemia, which is the most commonly seen form of inherited high cholesterol [3]. The LDLR gene contains instructions for making LDL receptors or low-density lipoprotein receptors. LDL receptors play critical roles in regulating levels of cholesterol in the blood by removing low-density lipoproteins from the bloodstream. Mutations in the LDLR gene can make the amount of LDL receptors produced less than normal or affect their job of removing the low-density lipoproteins in the blood [4]. People who have these mutations will have higher levels of cholesterol. There are many ways that the environment can affect the levels of cholesterol in the blood. Reducing the amount of dietary fat you consume lowers the total amount of cholesterol in the blood [5]. Sucrose and fructose can raise the amount of LDL in the blood. Reducing fatty foods will however lower the amount of LDL [5]. Having a healthy body and maintaining physical exercise plays a key role in keeping your cholesterol at a healthy level. If you are overweight or obese you can lower your cholesterol levels by simply losing ...
According to “Heart Disease and Marfan Syndrome” (n.d.) Marfan syndrome is caused by a change in the gene that controls how the body makes fibrillin, a part of connective tissue that contributes to its elasticity and strength. It is also stated that Marfan syndrome is mostly inherited from a parent, but 1 in 4 cases occurs when the patient has no known family history of the disease. To add, the condition occurs
The contributing factor is lack of knowledge and family medical screening. Understanding the history of your genetic line specific to your race and ethnicity may be helpful in preventing heart disease later on in adulthood.... ... middle of paper ... ... Current studies of note have focused primarily on middle-class and/or suburban populations.
A genetic family history assessment contains information about family structure and relationships. A typical nurse will use a three-generation family pedigree to gather the information. By doing so, nurses can be aware of which family members are at risk for disorders from a genetic component. Therefore, they can be provided with lifestyle advice, recommendations, and referrals to appropriate specialists (Kaakinen, Coehlo, Steele, Tabacco & Hanson, 2015). A genetic family history assessment will be provided about my family.
Your genetic information determines the genes you inherit that may cause or elevate your risk of certain medical conditions. My family genogram clearly indicates the risk of developing type 2 diabetes (T2D), heart disease (HD), hypercholesterolemia (HC) and hypertension (HTN). Heart disease is indicated on both maternal and paternal side and even though T2D only shows on my paternal side, the other diseases such as HC and HTN that are on my maternal side are risk factors for developing diabetes. According to Pessoa Marinho et al. (2013), the genetic and environmental risk factors that influence T2D development are: “age, gender, ethnicity, family history, obesity, inactivity, gestational diabetes, macrosomia, hypertension, decreased high-density lipoprotein cholesterol, increased triglycerides, cardiovascular diseases, micropolycystic ovary syndrome, high blood glucose on previous testing, impaired glucose tolerance and glycated hemoglobin ≥5.7%” (Pessoa Marinho et al., 2013, p. 570). Bianco et al. (2013) states, “the maternal influence confirms the hereditary role in the diabetes pathogenesis that women with positive family history to the illness presented...
Cardiovascular disease is developed by a build-up of fatty deposits on the inner walls of the blood vessels, which typically takes years to accrue (World Health Organization). The development of the fatty-acid deposits can occur due to an unhealthy diet, physical inactivity, tobacco use, and a harmful intake of alcohol. The behavioral risk factors listed above account for about 80% of cardiovascular disease, with the other 20% being cause by fixed risk factors (age, gender, race).
The tendency to build up high cholesterol may run in families, but extremely high levels are usually the result of a poor diet high in saturated fats and calories, along with little or no exercise. In some cases, high levels of cholesterol may be associated with undiagnosed medical symptoms such as diabetes or low thyroid function. According to the American Heart Association, there would eventually be a 50 percent lower rate of heart disease if Americans would lower their blood cholesterol levels by 25 percent. These statements find confirmation in a 1984 report done by the National Heart, Lung and Blood Institution on the results of a 10 year study. It showed that for every 1 percent of lowered cholesterol, the chances of a heart attack are lowered by 2 percent.
Family Health Problems Tree The purpose I searched for my family health history was to see what complications may occur in my future or in my family. There are a couple of benefits behind me researching the diseases throughout my family history, including that I can learn what is prevalent which may put me at risk of contracting it, it can help me change my lifestyle to prevent or lower my chances, and help me prepare for what may arise. The diseases that are most prevalent in my family that will most likely affect me or my brothers and sisters are Diabetes, Migraine, High Blood Pressure, and High Cholesterol. Diabetes is a disease that I came across when researching the maternal side of my family history.
Family lifestyle refers to the way that families live and their attitude, knowledge, and habits. Moreover, family lifestyle is an important determinant of family health. There are several aspects of lifestyle that affects health such as smoking, home safety and food safety. I visited Mr. Doed Mrs. Mary in order to understand the lifestyle better. They have three children, one boy and two girls. In this report, I will describe the family’s knowledge, attitude and practice in terms of smoking, home safety and food safety.