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Exchange Transfusion, Newborn
WHAT IS AN EXCHANGE TRANSFUSION?
An exchange transfusion is a procedure that removes your baby 's blood in small amounts and replaces it with donor blood or the yellow-colored liquid part of blood (plasma).
WHAT ARE SOME REASONS WHY MY BABY MIGHT NEED AN EXCHANGE TRANSFUSION?
Your baby may need an exchange transfusion if he or she has:
• Hemolytic disease of the newborn. Hemolytic disease happens when a mother 's disease fighting system (immune system) attacks her baby 's red blood cells. Proteins (antibodies) in the mother’s blood destroy the baby 's red blood cells. Two conditions can cause hemolytic disease:
○ ABO incompatibility. People with an O blood type have antibodies that can attack blood cells in type A or B blood. If a mother 's blood type is O and her baby 's blood type is A or B, her antibodies may destroy the baby 's red blood cells and cause hemolytic disease.
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An Rh factor is a protein on the surface of red blood cells. Rh incompatibility happens when a mother has Rh-negative blood and her baby has Rh-positive blood. During pregnancy or delivery, blood from the baby can cross into the mother’s bloodstream. If a mother is Rh-negative and the baby is Rh-positive, the mother’s antibodies can destroy the baby 's red blood cells.
• Jaundice. This is yellowing of the skin and eyes. In a newborn, jaundice is usually caused by a buildup of waste products in the blood due to the breakdown of red blood cells that the baby cannot get rid of fast
In most hospital delivery rooms, the doctors will routinely clamp and sever the umbilical cord with in fifteen to thirty seconds of the mother giving birth. When clamping the cord, the doctors will clamp the cord in two places, one close to the infant and then again in the middle of the cord another clamp. By delaying the clamping, fetal blood in the placental transfusion can provide the infant with an additional thirty percent more blood volume and up to sixty percent more blood cells (McDonald, S., & Middleton, P., 2009). This reduces the risk of the hemorrhaging that could occur after birth. But with new ongoing studies, it is said that by delaying the clamping of the cor...
Thrombocytopenia affects 6% to 10% of all pregnant women and, other than anemia, is the most common hematologic disorder in pregnancy (McCrae, 2010). Blood consists of three main ingredients: red blood cells, white blood cells, and platelets. Each plays an essential function to provide the human body with elements and protects the body against any exterior viruses and infections. Platelets are responsible for helping blood to clot. A deficiency or disorder of platelets leads to a disease called Thrombocytopenia.
In some individuals with severe hemophilia, the factor VIII replacement therapy is identified as a foreign substance by their immune system. If this happens, their immune system will make antibodies against factor VIII. These antibodies will inhibit the ability of the factor to work in the clotting process. The higher the antibody or inhibitor level, the more factor VIII replacement therapy it takes to overcome the inhibition and produce clotting. This can complicate the treatment of a bleed. The good news is that there are different types of therapies available to successfully treat most individuals who develop inhibitors.
One of the major problems of our society nowadays is the rapid growth of drug addicts. This is because people misused and abused drugs, which can lead to addiction and dependent on drugs. In addition, the most abused drugs are psychotropic drugs such as cocaine and heroin, which can change the way people thinks, acts and feels. Today, there are many programs that are established to help drug users and prevent the spread of diseases. Needle exchange program (NEPs) is one of the programs, which has goal to reduce harm to drug users and innocent people. Moreover, implementing of needle exchange programs has become an argument because it cannot help drug users but instead it encourages them to use more drugs. In fact, needle exchange programs are ineffective at reducing the spread of human immunodeficiency virus (HIV) and other infectious diseases; therefore, needle exchange programs should be abolished.
Great care should be taken in assessing the possibility of Rh incompatibility. This is an easily prevented condition to address before it becomes a problem for the baby when it is exposed to Rh-positive antibodies that can destroy the red blood cells (PubMed Staff, 2013). When the red blood cells are attacked as foreign, the baby can experience a range of health issues that can range from jaundice to brain damage, and even death (Dulay, 2014). An Rh-negative female should be tested and receive the Rho(D) immune globulin injection to ensure protection against the production of anti-Rh0(D) antibodies as a conservative measure to ensure that Rh disease is not of concern.
Out of the various amounts of genetic blood disorders in the world, Thalassemia is one of the more common known diseases. Thousands of infants with beta thalassemia are born each year. There are two different types of thalassemia related problems, alpha thalassemia, and beta thalassemia. The differences between the two types of thalassemia lie in the hemoglobin chain that is affected. For this paper the focus will be on beta thalassemia. Beta thalassemia is divided into three subcategories. The forms are thalassemia minor, thalassemia intermedia, and thalassemia major. The topics relating to beta thalassemia that are going to be explored are inheritance patterns, genes, mutations and proteins involved with Beta Thalassemia.
According to Lucile Packard Children’s Hospital, “In the United States, nearly thirteen percent of babies are born preterm, and many of these babies also have a low birth weight.” The baby may be put into the NICU for varies reasons. However, the most common reason that a child is put into the NICU is because he or she is premature. Premature means the baby was born before the 36 weeks. It is never good for a baby to be born early, as this could mean that the baby is not fully developed. There are other factors as to why a child may need to be put into the NICU after birth. For instance, birth defects can be the cause of why a baby is put into the NICU. A baby may be born with an infection such as herpes or chlamydia which can damage the newborns immune system at such a young age. Low blood sugar or hypoglycemia can also cause an infant to be put into the NICU. Some maternal factors of why a baby may be put into the NICU is if the mother is “younger than 16 or older than 40.” If the parent may be an alcoholic or expose the baby to drugs, this can put the child into NICU care. If the parent has an STD or sexual transmitted disease, the baby is most likely going to have to be put into the intensive care unit. “Twins, triplets, and other multiples are often admitted into the NICU, as they tend to be born earlier and s...
Hemophilia is a sex-linked hereditary bleeding disorder in which it takes a long time for the blood to clot and abnormal bleeding occurs. It is a hereditary blood coagulation disorder caused by a deficient activity of plasma protein factor thirteen and nine, which affects the clotting property of blood. A coagulation disorder is a disorder associated with platelets- blood cells essential for blood clotting. The platelets don't function properly in the body of hemophiliacs. There are two types of hemophilia: hemophilia A and hemophilia B. This disease affects mostly males.
In some cases, this infection can cause a dangerous complication called hemolytic uremic syndrome (HUS).
Thalassemia is basically a name for similar groups of inherited blood diseases that involve missing or abnormal genes regarding the protein in hemoglobin which is the red blood cells that carry oxygen throughout the body. I will discuss the different types of Thalassemia, how Thalassemia is diagnosed, and the treatments available. I will also discuss the complications and side effects of the treatments, the disease’s causes and effects, and how it is more dominant in some parts of the world than others. Thalassemia is a blood disorder which means the body makes fewer healthy red blood cells and less hemoglobin. Hemoglobin is a protein that carries oxygen throughout the body and having less hemoglobin leads to anemia. Alpha globin and beta globin are the proteins that create Hemoglobin. A defect in the gene that helps control production of alpha or beta goblin leads to Thalassemia. Fewer blood cells leads to anemia, which is the common culprit in Thalassemia.
II. Imagine your little nephew or niece baby was born with a heart defect and required daily transfusions of blood in order to have a chance at survival.
Albinism is a very serious disease that could end up in death. Albinism is a recessive inherited defect in melanin, which is metabolism in which pigment is absent from skin, hair, and eyes. Albinism in hair, skin, and eyes is called oculocutaneous albinism. Humans that have oculocotaneous albinism are not able to produce melanin. These people have white, yellow, or yellow brown hair, very light ( usually blue ) eyes, and very pale skin. Their eyes may appear pink because they have very little pigment.
When parents pass down their genetics to their offspring, they pass down eye color, height, blood type, etc. In some cases, unfortunately, parents also passed down genes for hereditary diseases like thalassemia. Thalassemia is a blood disorder passed down through families in which the body makes an abnormal form of hemoglobin, the protein in red blood cells that carries oxygen. The disorder results in excessive destruction of red blood cells, which leads to anemia (MedlinePlus, 2012). Hemoglobin is made up of Alpha globin and Beta globin, and thalassemia occurs when there is a mutation in a gene that helps control the production of one of these proteins.
Blood types can be categorized in many different ways. Karl Landsteiner categorized “the first three blood groups…[as] A, B and C (subsequently renamed O from the German word “ohne” which means “without”)” (Franchini 1545). Each of these blood groups also have unique properties that give the blood an inability to mix with other blood types. For example, Landsteiner has found out that type-A red blood cells contains an A-antigen and anti-B in its serum (Franchini 1545). Type A blood contains the monosaccharides N-acetylglucosamine, galactose, fructose, and “a N-acetylgalactosamine attached to galactose” (Timberlake 556).The A-antigen is used as an identifier for the body to determine whether something in the bodies system belongs or ...
There are two main types of thalassemia. The first one is Alpha thalassemia. This occurs when a gene or genes related to the alpha globin protein are missing or mutated. It happens mostly in Southeast Asia, the Middle East, China, and in those of African descent. If one gene is missing or damaged: Your red blood cells might be smaller than normal. You will have no symptoms and you will not need treatment. If two genes are missing or damaged, you will have very mild anemia that will typically not need treatment. This is called alpha thalassemia minor or alpha thalassemia trait. If three genes are missing: You will have mild to moderately severe anemia. This is called hemoglobin H disease. If it is severe, you may need blood transfusions.