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Basic pathology pancreatitis
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What is Pancreatitis?
The pancreas is a large gland that is located in the upper abdomen that secretes digestive juices, and releases insulin and glucagon into the bloodstream. Pancreatitis is a medical term for inflammation of the pancreas. When the pancreas is inflamed, it can progress to swelling of the gland, and surrounding blood vessels, bleeding, infection, and damage to the gland. It occurs when digestives enzymes start digesting the pancreas itself. Pancreatitis has two types; acute or chronic and either type can be life-threatening and have some serious complications.
What are the causes?
Alcohol abuse and gallstones are the two main causes of pancreatitis, accounting for 80% to 90% of all individuals diagnosed with the condition.
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The remaining 10% to 20% of causes of pancreatitis have various cases including medications, exposure to certain chemicals, injury (car accident or a bad fall leading to abdominal trauma), hereditary disease, surgery and certain medical procedures, infections such as mumps, abnormalities of the pancreas or intestine and high fat levels in the blood. About 80,000 cases of acute pancreatitis have been reported in the United States each year. It can occur in all ages in men and women; however it is very rare in children. On the other hand, chronic pancreatitis is more common in men than in women. What are the symptoms? The most common symptom of acute pancreatitis is abdominal pain. The pain may come so suddenly or will build up gradually and is located in the upper middle or upper left of the belly. The pain often begins or worsens after eating and typically lasts for a few days. It may feel worse when a person is lying flat on his or her back. Other symptoms may include nausea, fever, chills or both, swollen abdomen, and a rapid heartbeat. In severe cases with infection or bleeding, a person experience dehydration and low blood pressure. Pain is less common in chronic pancreatitis.
Some may feel pain but most do not. For those who experience pain, it is usually constant and disabling and it goes away as the condition worsens. This lack of pain is considered as a bad sign because it probably means that the pancreas has stopped working. Other symptoms are related to long-term complications such as inability to produce insulin, inability to digest food, bleeding and liver problems.
Risk Factors
Excessive alcohol intake and gallstones are the major risk factors for pancreatitis. Other risk factors include a family history of pancreatitis, high levels of fat in the blood, cigarette smoking, certain inherited disease such as cystic fibrosis and taking certain medications.
Diagnosis
When a health care professional identifies symptoms of pancreatitis, specific questions are asked about the person’s symptoms, lifestyle and habits, and medical and surgical history. These types of questions will help to rule out some conditions and make the correct diagnosis. In most cases, however, laboratory tests are needed. The tests will determine the function of several body systems including pancreas, liver and kidney functions, signs of infections, blood cell counts, and blood sugar, electrolyte levels and calcium level. Results of the blood tests may be inadequate if the pancreas is still making digestive enzymes and
insulin. Diagnostic imaging tests are usually needed to look for complications including gallstones. The tests may include x-ray films, CT scan, ultrasound, endoscopic retrograde cholangiopancreatography (ERCP). Treatments Medical treatments for pancreatitis are usually focused on relieving symptoms and preventing further aggravation to the pancreas. Depending on the complications, some may require a surgery or a blood transfusion. The main treatment for pancreatitis is to maintain a high carbohydrate, low fat diet along with medications for pain relief. In other cases, if the pancreas does not produce enough insulin, insulin injections may be necessary. It is important for the patient to follow the doctor’s treatment advice to avoid any necessary life-threatening complications.
In conclusion, 1 out of 10 people are at risk for gallbladder attacks. Gallstones are the main reason for these attacks. If you’re older, a female or overweight and have a sedentary lifestyle, a diet high in fat and sugar, you pose to be a potential candidate for these painful attacks.
This case study is about Abdul Chidiac, a 51 year old male, married with 4 children. He had a medical history of hypertension, hypercholesterolaemia and cirrhosis with two admissions in the last six months. He is a smoker and drinks beer, 5-6 bottles per day. As Carithers & McClain (2010) explained the patient’s medical history is another indicator of the risk for cirrhosis; the progression to cirrhosis is adaptable and may take time over weeks or many years. Cirrhosis is a liver disease characterized by permanent scarring of the liver that interferes with its normal functions including alcoholism. Most people who drink large amounts of alcohol cause harm to the liver in some way (Heidelbaugh & Bruderly, 2006). The cause of cirrhosis is not yet known, but the connection between cirrhosis and excessive alcohol ingestion is established (Jenkins & Johnson, 2010). Common causes of cirrhosis include: alcohol abuse, hepatitis B infection, hepatitis C infection and non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (Schuppan & Afdhal, 2008).
When you think of the repercussions of smoking you often think of lung cancer, but smoking also increases your chances of getting pancreatic cancer by almost 50%. You are twice as likely to get pancreatic cancer if you smoke than you would if you didn't. In addition, overweight people are twenty percent more likely to develop pancreatic cancer. Pancreatic cancer can also be hereditary, and you can be at a higher risk because of an inherited syndrome. African American people are also more susceptible to pancreatic cancer, the cause for this is not
The pancreas is composed of exocrine and endocrine tissues. The exocrine portion of the pancreas synthesizes and secretes pancreatic juices. The endocrine portion is composed of miniscule islands of cells, called the islets of Langerhans. These islets of Langerhans do not release their secretions into the pancreatic ducts. Instead, they release hormones into the blood stream, and these hormones in turn help control blood glucose levels (Function of the Pancreas). Beta cells of the islets of Langerhans secrete insulin, which
Liver disease resulting from alcohol affects more than two million Americans and is one of the primary causes of illness and death. The liver frees the body of harmful substances, such as alcohol. While the liver breaks down alcohol, it produces toxins that can be even more dangerous than the alcohol consumed (“Beyond Hangovers: Understanding Alcohol's Impact on Your Health” 13). “These by-products damage liver cells, promote inflammation, and weaken the body’s natural defenses. Eventually, these problems can disrupt the body’s metabolism and impair the function of other organs” (“Beyond Hangovers: Understanding Alcohol’s Impact on Your Health” 13).
The primary cause of hepatic cirrhosis in the United States is long-term alcoholism. Men respond differently than women to alcohol. With women one or two drinks a day can cause them liver damage. Men can consume two to five drinks a day and be ok. One drink a day can create liver scarring. So like everything else in life it varies, it might affect everyone differently. The individual who drinks alcohol on a daily basis, or more often then others have a higher risk of developing cirrhosis. Hepatic cirrhosis has also been linked to serious liver infections such as hepatitis B and hepatitis C. Patients who are HIV positive have died from developing cirrhosis through the hepatitis virus. Other causes of cirrhosis come from reactions to prescribed medications, injuries to the liver, exposure to toxic substances, and episodes of heart failure with liver congestion. Obt...
The pancreas uses these two hormones in order to monitor blood glucose levels. After a meal, blood glucose usually rises. This is when insulin secretion will start (Nussey S, Whitehead S. “Endocrinology: An Integrated Approach”). Consequently, blood glucose decrease to the normal range. This is how insulin maintains blood levels when is high. However, when blood level falls below normal range, glucagon comes into play. Low blood glucose occurs usually when hungry and during exercise. This will then triggers glucagon secretion. When blood level falls, the body goes into imbalance. Hence is why in order to maintain homeostasis glucagon is crucial. The body will tell the pancreas to increase more glucose and the pancreas will secrete glucagon by taking glycogen from the liver to produce glucose. The glucose will produce energy and will make blood glucose concentration increase (Homeostasis of Insulin and Glucose, Abpischools.org). When the pancreas cannot maintain homeostasis, many problems will arise in the body. When the pancreas fails to produce insulin, type 1 and 2 diabetes can occur. For those with type 1 diabetes, insulin injections will be needed in order to regulate blood glucose level, otherwise, glucose levels will be out of control. For type 2 diabetes, they are not insulin dependent like type 1, however, the body does not create enough in the body. When blood glucose
...e disease process of pancreatitis. This situation has changed my practice by looking more in-depth into disease processes and the complications I could be faced with. I need to beware of how conditions can change and always be one step ahead in foreseeing these changes to be able to deal with these situations when they arise.
Diabetes is a disease that I came across when researching my maternal side of my family history. Diabetes is a disease that affects your pancreas an important organ in regulating blood sugar. When a person has diabetes there are two ways it can affect the pancreas because there are two types of the disease. Type-1 diabetes affects the pancreas by not allowing the body to produce enough insulin to keep the body’s blood sugar at a healthy number. The opposite is for Type-2 which produces too much insulin and gives the body too much insulin keeping the blood sugar number above healthy (Type-2).
Many people that are alcoholics generally encounter heart attacks and liver disease. When you start to encounter a heart attack you will suddenly start to feel agony in your heart. Heart attacks can be threatening because it will cause you to suffer so much pain and the pain doesn’t go away even when you are resting and taking medicine. Heart attacks occurs when the coronary artery obtains a blood clots that clogs up the blood flow to the heart which cause the muscles in the heart to weaken and eventually causes the heart fail. Now when you encounter liver disease you are rolling toward a world of trouble you will start to lose weight, lose energy, and ect but it can get worst. Some alcoholics get the liver disease after many years of heavily consuming alcohol. Alcoholics can also encounter cancer in mouth & throat but not many alcoholics develop cancer from heavy drinking, it develop most when you smoke acreage of tobacco. Cancer in the throat is basically when the cells in your throat develops a genetic mutation. Cancer in the mouth is when the cells in your lips have a genetic
As a result, the pancreatic juices become thick and viscous potentially creating a plug that can cause a biliary duct blockage (2,14, 15). Duct obstruction from pancreatic juice and its content increases pressure, leading to distension of the duct also (13, 14, 15). At a cellular level, membrane trafficking becomes chaotic, potentially leading to Trypsinogen activation into trypsin, initiating the cascade of digestive enzyme activation and autodigestion of the pancreas, causing AP (13,14, 15). Alcohol abuse further prompts acinar cells to release inflammatory cytokines, attracting a strong immune reaction causing pancreatic tissue destruction (13,14,
Risk factors for both Cholecystitis /cholelithiasis includes obesity; rapid weight loss in obese individuals; middle age; female gender; use of oral contraceptives; American Indian ancestry; gallbladder, pancreatic, or ileal disease; low HDL cholesterol level and hypertriglyceridemia; and gene-environmental interactions (Doig &Huether, 2014).
There are no symptoms in the early stages of pancreatic cancer. Later stages include symptoms such as loss of appetite, unexplained weight-loss, pain in abdomen or middle back, dark urine, itchy skin,
How To Manage Type 1 Diabetes? Summary: Type 1 disease is a major illness that used to affect kids and adolescences, but now it’s affecting adults as well. To control your diabetes, you need to know all the things related to it. Learn how to manage type 1 diabetes, so that you live a long & healthy life.
Alcoholism, diabetes, anti- cancer therapy and ingestion of toxins are among the several known causes of