Nasopharyngeal carcinoma is one of the head and neck cancer and it’s incidence is less than 1 per 100000 population (about 2-3%). Surgery, chemotherapy and radiotherapy are common treatment modalities for nasopharynx cancer. Nasopharynx is surrounded by critical organs such as brain stem, spinal cord, temporal lobes, eyes, middle and inner ears and parotid glands; so it is impossible to deliver high doses to the tumor. Therefore, nasopharyngeal carcinoma presented a challenge to radiotherapy and treatment results are not satisfactory. Ionization radiations are used in radiotherapy for cancer treatment and these radiation can control rapid cell growth. Nowadays, radiotherapy is converted to one of the most important modality of cancer …show more content…
These NPs are absorbed by cancerous cells and play an important role in photothermal therapy. In addition, iron oxide NPs induce DNA damage and necrosis/ apoptosis because these NPs convert to iron ions and generate free radicals and ROS. Gold NPs are one of the most popular NP that have been widely used in researches for their inertness, biocompatibility, easy synthesis in different sizes and shapes. Due to their small size, gold NPs are absorbed in blood circulation and they have good permeation in tumor tissue. This is called enhanced permeation and retention effect (EPR). Due to their unique optical properties and high z (z= 79), AuNPs are ideal for hyperthermia and radiation sensitization, respectively. Radioresistant cells- S- phase cells and hypoxic cells- are very sensitive to hyperthermia; hyperthermia increases the oxygen level in tumoral cells, so cell sensitivity to radiation will be increased; hyperthermia suppresses the repair of non- lethal damage from radiotherapy; according to these explanations radiotherapy and photothermal therapy have synergistic effect and combination of these two modalities will improve cancer treatment
Fitzgerald, M., et al. “Red/near-infrared irradiation therapy for treatment of central nervous system injuries and disorders.” Rev. Neurosci. 24.2: (2013): 205-26.
Nasopharynx is located at the top of the pharynx, posterior to the nose and above the soft palate. The nasopharynx is lined by a thin layer of respiratory epithelium and most nasopharyngeal carcinoma arises from these cells, that are large polygonal cells with a syncytial composition. The nasopharynx is a part of the pharynx together with the oropharynx and hypopharynx. The main function of the nasopharynx is respiration as it connects the nose to the rest of the pharynx (Marieb & Hoehn, 2007). This structure allows air to flow into the lungs and thereby if it’s primary function is disturbed, the clinical manifestation that would be seen would involve respiration. In this patient, what is most relevant social history is patient smoking history in relation to her nasopharyngeal carcinoma.
...ith photodynamic therapy. Neoplastic tissues would take up compounds of photosensitizing agents, and the interaction of light with the photosensitizing agent eventually leads to the production of cytotoxic free radicles[secret]. The advantages of this treatment is that multiple lesions could be treated even though that could take more than one treatment. However, the downside to this treatment is that it is limited only to neoplasms that are at superficial level. Patients might also acquire side effects such as having photosensitization for around 4-6 weeks, or causing tissues to undergo necrosis which sloughs off after some time.[secret] The latter effect would induce pain in patients.
There are essentially three main types of cancer treatments; surgery, chemotherapy, and radiation. Surgery allows doctors to effectively remove tumors from a clear plane. Chemotherapy uses drugs to treat the tumor; but often the drugs affect other healthy cells in the process. Using radiation as a treatment can be either precise or vague. Many health stigmas can come from the vague forms of radiation or conventional radiation therapy. Conventional radiation treats both the unhealthy and healthy cells, therefore exposing healthy cells to harmful radiation (Radiation Oncology, 2011, p.6). When healthy cells are exposed to gamma radiation they are also exposed to ionizing radiation. The ionization can cause “breakage of chemical bonds or oxidization (addition of oxygen atoms)” in a cell; the main impact of this is on a cell’s DNA, if two strands of DNA break it can result in “mutations, chromosome aberrations, ...
Osteosarcoma, characterized as a neoplasm that produces osteoid, is a highly malignant tumor that develops predominantly in the metaphysis of the long bones, often in the distal femur and proximal tibia. More rare osteosarcomas may develop in the soft tissue. Although the malignancy usually arises in the medullary cavity of the metaphysis of a growing tubular long bone, less frequent growth patterns can develop on the surface on the bone. Surface osteosarcomas, as well as being significantly rarer, are also of a low grade, where else medullary osteosarcomas are of an aggressive nature, making it high grade. Osteosarcomas may also be confined to the cortex, and can even originate in an extraskeletal site.
About 45,000 new cases of head and neck cancers are occurring every year in United States. Among them, estimated 20% are human papilloma virus (HPV) infected cancers. The tonsil, base of tongue and lingual tonsil, other potentially HPV-associated oropharynx, oral tongue, other oral cavity, larynx, and other HPV-unrelated oropharynx are all to be considered to be different part of head and neck cancer (HNC) in the study (Ryerson et al., 2008).
I have chosen to write about the constellation Cancer (The Crab). I chose Cancer because it is one of only a handful of constellations that I am actually able to identify in the night sky. Cancer is one of the twelve Zodiac constellations; people whose birthdays fall between June 21st and July 22nd have Cancer as their sign. Cancer is the Latin word for crab, and despite the fact that the constellation looks more like a lobster then a crab, it is still referred to as a crab. The constellation is visible from the northern hemisphere from late winter to early spring.
High oxidative a stress is known to cause global cellular damage by creating reactive oxygen species (ROS) which causes damage to proteins, lipids and DNA (15, 82). Oxidative stress increases protein phosphorylation, causing changes to signaling pathways. For example, several phosphatases involved in cancer, apoptosis and aging are inactivated under conditions of high oxidative stress (26). ROS is a known contributor to several diseases including Alzheimer’s, Parkinson’s, Huntington’s, kidney disease, and T2DM (25, 27, 105). Known mediators of oxidative stress include transition metals and mitochondrial dysfunction (15, 27). In this project, I will be studying how cellular iron regulation causes an increase in oxidative stress, contributing to cellular damage and disease. Aconitase is an important mediator of oxidative stress, metabolism and iron regulation.
2016, pg. 144). Beam-restriction devices lower the amount of tissue that is exposed to radiation
The leading cause of death in America is lung cancer. Lung cancer is ranked top 10 fatal cancers in the United States. There are many types of ways to get lung cancer. There is radon gas it occurs outdoors naturally. Then there is second hand smoke that comes from other people smoking. People are even getting lung cancer from cancer causing agents, this happens from carcinogens. You can also get it from air pollution indoors and outdoors. Also there are gene-mutations that form cancer causing cells. Then there is the one everyone blamed lung cancer is smoking.
“External radiation uses a machine that directs high-energy rays from outside the body into the tumor and some normal nearby tissue.” (American Cancer Society p. 5) After this treatment the patient will not be radioactive, but treatment is delivered in small doses and can last several weeks. “Internal radiation or brachytherapy, uses a radioactive source, called an implant, that’s put inside the body in or near the tumor.” (American Cancer Society p. 9) It may be placed in an organ or in the cancerous tumor. The patient will be radioactive for a short time. Due to the implant being near the source of cancer a larger dose can be delivered to the patient. “Systemic radiation uses radioactive drugs to treat certain type of cancer.” (American Cancer Society p. 12) The drugs used are called radiopharmaceuticals and can be delivered orally or intravenously. “They collect where the cancer is to give off their radiation and kill the cancer cells.” (American Cancer Society p. 12) After this treatment the patient will be radioactive, and will take a few days to be removed from the patients
Radiation therapists work closely with patients to fight cancer. According to Health Care Careers, Oncologists, Dosimetrists and nurses are some of the professionals that a radiation therapist works with while caring for a cancer patient. This group of professionals will determine a specialized treatment plan. The first step usually includes a CT scan performed by a radiologist to find the exact area that needs to be targeted with x-rays. Next, the therapist uses a special machine that emits radiation called a Linear Accelerator. They use this machine during a treatment called external beam therapy. During this process, the Linear Accelerator will project x-rays at targeted cancer cells or tumors. Another therapist will be in a different room monitoring the patient’s viral signs until the procedure is over. The external therapy l...
Cancer patients often wonder if going through treatments like chemotherapy and radiation are worth the risk of the side effects, in addition to the cancerous side effects. They feel that they can’t enjoy or relax in what a short amount of time they have left because they are bedridden from the nausea and pain that treatments put them through. Patients tell their loved ones to just let them die so long as they don’t have to go through any more pain. Those who are too old, are unable to recover from the effects, or are just too far in the grips of cancer, should refuse the more harsh treatments like chemo and radiation. On the positive side, refusing treatments after a certain point can save their families from the stress and cost of hospital bills. If caught early enough, patients can opt for safer and easier routes to getting rid of cancer like surgery or by doing a stem cell transplant.
The topic that I will be focusing on for this assignment is on the screening of lung cancer, since this is one of the most controversial debates all across the world. The significance of this topic is that when it comes to lung cancer screening, many individuals may or may not abide by it. There are many reasons to why individuals may not want to have their screening done for lung cancer. The top two reasons are that the screening itself is expensive and secondly, the results that they get from the screening may not be accurate. Imagine, if the results came up as a positive, for the ones who really do not have lung cancer, the amount of pain, time and money that they have put into the curing of lung cancer, is painful. At the same, time it is not fair for them to go through this much, when they actually do not have lung cancer. In this paper, I will discuss how lung cancer screening is a controversial issue and why it impacts us as a society and what problems that the family members, friends and medical doctors have to face if something does goes wrong.. Here is a portion of my essay that will appear on the final copy of my essay.
Hypothermia, an older treatment, is the treatment of utilizing heat to treat cancer, but had commixed results. Hyperthermia denotes a body temperature that is higher than mundane. High body temperatures are often caused by illnesses, such as fever or heat stroke. But hyperthermia can additionally refer to heat treatment, the conscientiously controlled utilization of heat for medical purposes. Here, we will fixate on how heat is utilized to treat cancer. When cells in the body are exposed to higher than mundane temperatures, changes take place inside the cells. Very high temperatures can kill cancer cells outright, but they additionally can injure or kill mundane cells and tissues. This is why hyperthermia must be punctiliously controlled and should be done by medicos who are experienced in utilizing it. The conception of utilizing heat to treat cancer has been around for some time, but early endeavors had commixed results. For instance, it was hard to maintain the right temperature in the right area while inhibiting the effects on other components of the body. But today, more incipi...