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Benefits and Side Effects of Photodynamic Therapy
Symptoms and Presentation of Cancers in Feline
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Most animals are susceptible to the development of cancer at some stage of their life. Among all types of cancer, squamous cell carcinoma is one of the skin cancer that commonly affects domestic animals. Cutaneous squamous cell carcinoma is a type of cancer caused by neoplasms arising from the squamous epithelium of an animal regardless of species. However, this essay will only focus on this condition among felines since my chosen species is a white cat called Rosie. There are several forms of cutaneous squamous cell carcinoma among felines, which are known as solar keratosis and multicentric squamous cell carcinoma in situ, sometimes known as Bowen’s-like disease, but in this case, Rosie is diagnosed with
The presentation of squamous cell carcinoma varies according to stages of the cancer, types of lesions, and the underlying causes of neoplasm. Felines presented with squamous cell carcinoma would typically have lesions, erosions, crusting of epithelial cells, ulcerations and sometimes necrosis in serious conditions. At early stages, the cat would develop hyperplastic lesions and inflammation around the affected area. It will look erythematous and slightly crusty or scaly. As time passes, the signs become worse where the lesions become proliferative which exhibits a look of cauliflower- like masses. They are often ulcerated and have crusted lesions. Unfortunately, it bleeds easily when it is traumatized. The favored area of the neoplasms are usually at nose, eyelids, and pinnae where there are lack of pigmentation.
There are several causes that contributes to cutaneous squamous cell carcinoma (SCC), which mainly are prolonged sunlight exposure, presence of trauma, exposure to carcinogen, and being affected by papillomavirus.[...
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...ith photodynamic therapy. Neoplastic tissues would take up compounds of photosensitizing agents, and the interaction of light with the photosensitizing agent eventually leads to the production of cytotoxic free radicles[secret]. The advantages of this treatment is that multiple lesions could be treated even though that could take more than one treatment. However, the downside to this treatment is that it is limited only to neoplasms that are at superficial level. Patients might also acquire side effects such as having photosensitization for around 4-6 weeks, or causing tissues to undergo necrosis which sloughs off after some time.[secret] The latter effect would induce pain in patients.
Tumours that are treated at early stages have a higher chance to heal. Besides that, lesions that are well differentiated and that are superficial also have a better prognosis.
The Cancer Council NSW and NSW Health Department Skin Cancer Prevention Strategic Plan for New South Wales (2001) Gladesville NSW The Cancer Counsil New South Wales and NSW Health Department 2001
Whiteman, D. C., P. Watt, D. M. Purdie, et al. "Melanocytic Nevi, Solar Keratoses, and Divergent Pathways to Cutaneous Melanoma." Journal of the National Cancer Institute 95 (June 4, 2003): 806–812.
Skin cancer is a significant public health issue in Australia. Exposure to ultraviolet radiation emitted by the sun in the UVA and UVB wavelengths is the primary cause. Australia has been a world leader in efforts to protect the ozone layer, the main line of defense against ultraviolet radiation emitted by the sun. Ultraviolet radiation induces the formation of thymine dimers that cause mutation of skin cells if not repaired before DNA replication. Mutations of tumor suppressor genes can lead to uncontrolled cell growth. Ultraviolet radiation also causes immunosuppresion that allows skin cancers to become established. Basal cell carcinoma, squamous cell carcinoma, and melanoma are types of skin cancer caused by sun exposure, though each form is associated with a different pattern of exposure. Australia has the highest rate of skin cancer in the world, due to a combination of tropical latitude, fair-skinned population, outdoor lifestyle, and high amount of ambient ultraviolet radiation. Widespread opinions about tanning and health benefits of sunlight lead many Australians to intentionally overexpose themselves to the sun. State cancer councils have developed sun safety and awareness campaigns, such as “Slip! Slop! Slap!” and “SunSmart,” to educate the population about sun exposure and encourage early detection of skin cancers. Gradual changes in knowledge and behavior indicate that the fight against skin cancer can be won.
Basil Cell Carcinoma is the most common form of skin cancer. It usually begins as a mole (skin melanoma) on your body; however this cancer can also begin in other areas such as your eye or intestines. This cancer is also the most dangerous type of skin cancer. If diagnosed and treated early, it is almost always curable. There are roughly 2.8 million cases of this cancer diagnosed each year
A regular skin exam (every 6-8 weeks) will help in the melanoma dectection process. Look for irregular skin growths and have the growth examined by a health care provider if the growth promotes cause for alarm.
Because of advancements in technology and funding survival rates have increased in each patient and quality of life due to better chemotherapy and radio therapy drugs are helping millions of survivors round the world to lead a generally normal life without the risk of the cancer returning.
According to Essentials of Human Disease and Conditions textbook, “The most important prognostic factors are age at diagnosis, size of the primary tumor, and the presence of tissue invasion or metastases. (American Cancer Society, 2012)
Basal Cell Carcinoma often abbreviated as (BCC) is the most frequently appearing form of skin cancer. They are also referred to as Basal Cell Cancer. It was discovered along the way as skin cancer was being treated as different types with no specific period. The BCCs’ are uncontrolled growths that normally arise in the skin’s basal cells. These cells lie in the deepest layer of the epidermis which is the outermost layer of the skin. BCC’s are normally caused by a combination of two things; one is cumulative UV exposure and the other is intense occasional UV exposure. The most vulnerable, according to a research done, tend to be people with fair hair, blue eyes and fair skin and this is because they tend to burn easily. The BCCs’ may first appear as a small white flesh or a colored bump that may bleed. Other normal appearances may look like open sores, red patches on the skin, pink growths, shiny bumps or scars. 80% of Basal Cell Carcinoma cases are mainly found in the head and neck that is the body parts that are mainly exposed to the sun. The nose also tends to be most vulnerable and according to a recent study done, 40% of BCC that were diagnosed on the head and neck were adjacent to the nose.
Though cats are less likely to get cancer than dogs, there are many different types of cancers that a cat can contract. Some of the most comon are Lymphoma, Skin Cancer, Gingiva Oral squamous Carinomas or mouth cancer, and Osterocacroma. Lymphoma is a type of cancer that starts in the Lymphocyte Cells, a type of whote blood cell. Lymphocyte Cells play an important part in the immuine system. Lymphoma is found to be responsible for around 90% of blood cancers and about 33% of all tumors in cats. Its also the most common cause of hypercalcemia in cats. (Science Weekly, 2012) Skin cancer in cats often appears like a white plaque or a raised bump on the skin. The bump will often ulcerate with occasional bleeding. These type of carcinomas are usually malignant, early detection and treatment is best. These cancerous cells can easly spread just like any other cancer to other organs. Skin cancers are more likely in cats that live in high altitudes or cats with light, esspecially white, coats. (Crain, D, 2005) Gingiva Oral squamous Carinomas, or mouth cancer, is particularly deadly, moving quickly though the body, with usual fatal results. These tumors grow very rapidly and usually invade to nearby bone and tissue. These carcinomas are usually seen in oldercats. (PetMD, 1999- 2014) Osteosacroma is the most common milignant bone tumor in veterinary practice. This cancer is especially painful, the most comon places for these tumors are the humerus, femur, and ti...
We now can find what specific cancer a patient has and where, and give them a variety of treatment options such as surgery, chemotherapy, radiation, and several other types of treatment including experimental drugs. But there is no 100% guarantee that these treatments work. Ancient physicians and surgeons knew that cancer usually came back after it was removed surgically and recognized that there was no cure once the cancer had spread, and thought that intervention may be more harmful that no treatment at all. Some people today still think of cancer as incurable and wait until the last minute to go to the doctor. Galen was a 2nd- century Greek doctor that claimed a breast cancer tumor could be completely removed if it was caught at an early enough
Skin cancer is a disease where cancer (malignant) cells are found on the outer layer of the skin (epidermis). The three types of cells found in the epidermis are squamous cells, basal cells, and melanocytes. These cells in time grow to be cancerous. Thus, the three types of skin cancers are squamous cell, basal cell, and melanoma. Melanoma is the most deadliest and destructive type of cancer. (“Skin Cancer” infotrac.com) The number of people with melanoma has risen in Scotland from 3.5 in 1979 to 10.6 per 100,000 in 1998 for men and 7.0 to 13.1 for women. (Miller 945) Squamous cell and Basal cell skin cancer can kill up to 2,200 people a year in the United States. (Sommerfield SIRS.com) Basal cell, being the most common type of skin cancer, is the cancer that about 75 percent of the people have. (“Skin Cancer “ infotrac.com) Melanoma is mostly seen in older men but ever since tanning came in during the 1970’s, it has increased in women 60 percent around the ages 15-29 over the past three decades.(Sommerfield SIRS.com) “And basal cell and squamous cell cancers are increasing at a rate of about 5 percent per year”(Sommerfield SIRS.com).
...cations. Many people will find that amount of sunlight they receive has little or no impact on the state of their psoriasis, but in the cases where the light therapy has worked, it seems to reduce the appearance of the lesions greatly. Obviously, the risk of the UV light therapy is the possible threat of skin cancer.
The Phase I trial will be discussed here as it pertains to the topic at hand. The typical treatment for cervical cancer if surgery is not a viable option – like if the cancer has spread, then called locally advanced cervical cancer – is chemotherapy and radiation treatment at the same time. This phase I clinical trial is simply looking to add ipilimumab to this regimen, but once the chemo/radiation has been completed (LACC article). Chemo and radiation destroy tumor cells, which causes tumor-associated antigens to be released. Once released, these antigens are exogenous (outside the cell) and will be presented to helper T cells to initiate an immune response.
Every day there are millions of cats around the world that contract a broad range of illnesses. When an owner’s feline companion becomes ill, it is good for them to recognize any clinical signs that may be present and know whether their cat had the potential to come into contact with an unknown animal if an interaction was not seen. Information like this will help the veterinarian to make a proper diagnosis and create a treatment plan for the animal. Some illnesses can be potentially fatal and can possibly be spread to other pets in the household, so it is important to make sure the cat receives medical attention when it starts to show signs of illness. One disease that any cat owner should be aware of is Feline leukemia (FeLV).
Bone cancer is classified into primary bone cancer & secondary bone cancer. Basically, Primary bone cancer starts in the bone; then the cancer initially forms in the cells of the bone; while the secondary cancer starts elsewhere in the body and gets spread to the bone.