The People that could be Considered Iron People
One in every two hundred people with Northern European ancestors are affected with hemochromatosis (Fletcher and Halliday 182). This is one of the most common blood disorders in the United States, and one in every eight to twelve white Americans is a carrier of this disease ("Hemochromatosis,” Cleveland 3). You or someone you know may be a carrier of hemochromatosis. My mom has hemochromatosis. She was diagnosed with the disease in 2007. She had many problems, including joint pains, being tired, and fatigued. Her doctors diagnosed it as many different diseases until a blood sample was taken. It showed that her iron levels were double what they were supposed to be. So my family gave her the nickname, iron women. Hemochromatosis is a common disease, but it has effects on a person’s organs, body, and life. Hemochromatosis is a disease
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The different types include: juvenile, neonatal, and secondary. Juvenile hemochromatosis occurs at a much younger age before or during puberty. This disease has many of the same effects as hereditary hemochromatosis, but juvenile affects different hepcidin genes. This is a hormone produced and controlled by the liver (Mayo, “Symptoms” 4). Another type of hemochromatosis is neonatal hemochromatosis. This type occurs to a fetus while it is still in the mother’s womb. The iron builds up in the liver over the final days of pregnancy (4). This disease progresses at an extreme rate, and a few days after birth the liver will start to shut down and fail. The only treatment for this disease is a liver treatment and there is only a fifty percent survival rate (Machtei et al 1). Another type that is not inherited is secondary hemochromatosis. This type is caused by having too many blood transfusions cause too much iron to be stored in a person’s system (Mayo, “Symptoms”
Originally thought to be an obscure illness, it was later identified as the most common genetic disorder for those with a Western European background. However, due to its low penetrance rate, only one out of two hundred are said to have the condition. Hemochromatosis is treated by the practice of bloodletting. It is one of the oldest treatments recorded in history, with its earliest records dating as far back as 3000 years ago in ancient Egypt. Routinely bleeding is beneficial as it not only reduces the iron in the bloodstream, but also combats issues such as heart disease and high blood
• Hemolytic disease of the newborn. Hemolytic disease happens when a mother 's disease fighting system (immune system) attacks her baby 's red blood cells. Proteins (antibodies) in the mother’s blood destroy the baby 's red blood cells. Two conditions can cause hemolytic disease:
http://www.patients.co.uk/health/hereditary-spherocytosis. htm#.21/02.12. November 14, 2013 Wint Carmella. The "Hereditary Spherocytosis" http://www.healthline.com/health/congenital-spherocytic-anemia. November 12, 2013.
Haemophilia is used to describe a collection of hereditary genetic diseases that affect a mammal’s body’s capability to control thrombogenesis. Thrombogenesis is the way in which blood clots which is an important role in haemostasis. Two common forms of haemophilia are A and B. (1) Someone with A (otherwise known as classic haemophilia), clotting factor VIII is does not exist enough or is entirely absent. A person with haemophilia B (otherwise known as Christmas disease), clotting factor does not exist enough or is also entirely absent. Those with the disorder do not bleed a lot they just simply bleed for a longer period of time. All people with haemophilia A or B are born with the disorder as it is a hereditary disorder and passed down through generations very few cases of haemophilia are not genetic and are therefore rendered a spontaneous gene mutation which is then passed down.
Thalassemia is an inherited blood disorder characterized by low amounts of hemoglobin and a low count of erythrocytes in the body. Thalassemia is caused by mutations in the deoxyribonucleic acid of cells, which makes hemoglobin. The mutations are passed from parent to child. The mutations vary depending on the type of Thalassemia inherited. The variation in the mutation occurs from the number of gene mutations, which are inherited, as well as mutation within the hemoglobin molecule. Clinical manifestations are diverse ranging from asymptomatic, to those who are carriers of the thalassemia, which may have mild symptoms, there also people who posses the trait, who may have severe symptoms which lead to death.
disorder will be present. Whether or not a child will have hemophilia or be a carrier for
Your genetics load the gun .your life pulls the trigger.(Mehmet Oz).in life your already born without knowing destiny. Although you may have a condition you can let it break you.
Thalassemia is basically a name for similar groups of inherited blood diseases that involve missing or abnormal genes regarding the protein in hemoglobin which is the red blood cells that carry oxygen throughout the body. I will discuss the different types of Thalassemia, how Thalassemia is diagnosed, and the treatments available. I will also discuss the complications and side effects of the treatments, the disease’s causes and effects, and how it is more dominant in some parts of the world than others. Thalassemia is a blood disorder which means the body makes fewer healthy red blood cells and less hemoglobin. Hemoglobin is a protein that carries oxygen throughout the body and having less hemoglobin leads to anemia. Alpha globin and beta globin are the proteins that create Hemoglobin. A defect in the gene that helps control production of alpha or beta goblin leads to Thalassemia. Fewer blood cells leads to anemia, which is the common culprit in Thalassemia.
Primary structure of haemoglobin- This is the first level of protein structure. Haemoglobin is made up through the linking of amino acids which form polypeptide chains
...l risk factors that are fully linked developing multiple myeloma. Therefore, preventative measures remain unknown.
in Hematology on a regular basis, but there were still things I learned by going through
There are two main types of thalassemia. The first one is Alpha thalassemia. This occurs when a gene or genes related to the alpha globin protein are missing or mutated. It happens mostly in Southeast Asia, the Middle East, China, and in those of African descent. If one gene is missing or damaged: Your red blood cells might be smaller than normal. You will have no symptoms and you will not need treatment. If two genes are missing or damaged, you will have very mild anemia that will typically not need treatment. This is called alpha thalassemia minor or alpha thalassemia trait. If three genes are missing: You will have mild to moderately severe anemia. This is called hemoglobin H disease. If it is severe, you may need blood transfusions.
Polycythaemia is a blood disorder defined as an increase in blood erythrocyte concentration. Absolute polycythaemia is where this increase is caused by greater erythrocyte production, determined by measuring the haematocrit level, with one study showing that 83% of sufferers have a haematocrit level of >55%. This should not be confused with relative polycythaemia, caused by a decrease in blood plasma volume often secondary to hypertension. Interestingly, those affected tend to also have increased blood platelet and white cell concentrations, which correlates well with the notion that the disease is caused by a genetic defect in the haematopoietic stem cell population within the bone marrow. Studies have shown the median age of onset to be 60, although a Mayo Clinic study in Olmstead County, Minnesota showed it to be slightly higher, at between 70 and 79 years, with men affected more than women – though the reason behind the gender inequality is currently unknown. In addition, its prevalence within the US is thought to be in the region of 50/100,000. Furthermore, it has long been known that Finnish skier and seven time Olympic champion Eero Mantyranta suffered from the disease, and it is often stated that his success, at least in part, can be put down to his polycythaemia – indeed experiments have shown that it can increase the blood oxygen carrying capacity by up to 50%, an undeniable asset to any endurance athlete. However, the disease can also prove fatal in many cases because the thickened blood increases the probability of clot formation, giving deep vein thrombosis and potentially pulmonary embolus. It is this double edged nature of polycythaemia that first took ...
I will be investigating Human Blood as my specific tissue and giving an overview on the location, characteristics, and the benefits it has to the human body. Blood is extracellular matrix that is consists of plasma, red blood cells, platelets, and white blood cells. Blood is located within the capillaries/veins/arteries of the human body, which are blood vessels that run through the entire body. These blood vessels allow the blood to flow smoothly and quickly from the heart to distinct parts of the human body. The unique parts of human blood all work together for a purpose: the Red Blood Cells(erythrocytes) transports oxygen throughout the body, White Blood Cells(leukocytes) play a part in the bodies immune system, Platelets(thrombocytes) assist in creating scabs,