I'm sure you have heard about diabetes before, right? Diabetes has become a major problem globally as it is associated with a higher morbidity and mortality rate. As a medical worker, documenting a detailed history of medical illness is important when it comes to identifying the aetiology of current diagnosis. Each time when I asked a question regarding medical illnesses among people who are in the late adulthood or elderly patients, the majority of them has diabetes mellitus as one of the comorbidities. In the United States alone, 9.4% of the general population which is equivalent to approximately 30 million individuals have been diagnosed with diabetes mellitus in 2015. Approximately 80 million people have the sign of prediabetes which could …show more content…
This type of glucose transporter is efficient in a condition whereby the concentration of circulating blood glucose is low. If the level of blood glucose is high i.e. in an uncontrolled diabetic patient, the expression of this glucose transport protein would be low which would make the reuptake process of glucose quite sluggish. Theoretically, glucose can't stay for long in the blood circulation as they can interact with the circulating protein which would cause them to form the advanced glycation end product (AGE) in a harmful process called …show more content…
Sorbitol would become the reactant to the second part of the polyol pathway. It will be converted into fructose by sorbitol hydrogenase with the help of nicotinamide adenine dinucleotide (NAD+) as a cofactor which will be reduced to NADH. So how's the production of fructose affect the body? There are two ways how the production of intracellular fructose can be quite damaging: The fructose would be phosphorylated to a compound called fructose-3-phosphate The resulting compound, fructose-3-phosphate can be broken down into 3-deoxyglucosone. Both of the compounds formed can serve as substrates for the production of advanced glycation end products (AGE). AGE is a damaging compound which can be found abundantly in a diabetic patient. We will discuss how damaging can this compound be, in my next article. Pixabay The NADH produced by the reduction process of NAD+ can be utilised by NADH oxidase to produce a superoxide free radical. This is achieved by an electron transfer from the NADH to an oxygen molecule. It is fascinating, isn't it? The fact that a single reaction can cause so much damage to the body. Activation of polyol pathway not only will hinder the capacity of our body to prevent oxidative damage, but it will also increase the insulting oxidants which will accelerate the cellular
Moutzouri E, Tsimihodimos V, Rizos E, Elisaf M. Prediabetes: To treat or not to treat. European Journal of Pharmacology. 2011;672:9-19.
(Specific Connective Type) Now that you know that the insulin’s job is to lower blood glucose, let’s look at what could happen if the insulin did not do its job.
Peppa M, Uribarri J, and Vlassara H. Glucose, Advanced Glycation End Products, and Diabetes Complications: What Is New and What Works. Clinical Diabetes October 2003 vol. 21 no. 4 186-187.
The effects of a disorder with insulin can be very grave because this hormone is very important to the body. First I would like to discuss Diabetes Type 1. This disease, also called juvenile diabetes, is usually diagnosed to children or young adults. Off all the people with diabetes, only five percent of the people have type one diabetes. 10Type one diabetes is a condition in which the immune system destroys the cells in the pancreas which produce insulin. Type 1 diabetes is not associated with lifestyle habit; and it is neither curable nor preventable. So you my reader could receive this disease and never know how you got it or how to prevent it! At least you can know when you get though. Some of the symptoms are excessive thirst and urination,
Introduction Peritoneal dialysis is a procedure that filters your blood. You may have this procedure if your kidneys are not working well. You can perform peritoneal dialysis yourself, or a machine can do it for you at night when you sleep. Tell a health care provider about: Any allergies you have.
As you may or may not already know, diabetes is a non-communicable disease. Learning about diabetes interests me because my grandmother and grandfather are both diabetic. I see what they go through every day with pricking their finger, injecting insulin and watching what they eat. It seems to be a hassle, but for them- it’s their life.
Today I am going to be choosing diabetes for my medical topic. There are several types of diabetes. There is type 1 diabetes, type 2 diabetes and gestastional diabetes. Our body naturally produce insulin and but sometimes there are cases where are body doesn’t produce enough insulin or does not properly respond to the insulin produced which results in high blood sugar levels. High blood sugar levels is not healthy for our bodies because it can lead to us going into a coma. If this is left untreated it can cause very serious health problems including death.
Diabetes is becoming an epidemic. In fact, in 10 years many experts believe that people who suffer from diabetic is going to double. Kids who are as young as 8 years old are now borderline type 2 diabetics.
According to the WebMD, Health Services Group, there is a complication that is usually connected with prediabetes, other then it leading to type 2, like heart disease that can possibly develop in early diabetes ( WebMD, 2015-2017).
My interest in this topic is a result of recent experiences with Diabetes Mellitus, Type 1 (DMI), especially with the following two instances: a young adult patient admitted at the hospital following a DKA episode during one of my nursing rotations and one of my instructors with type 1 diabetes. Also, my father was diagnosed with type 2 diabetes, this has increased my eagerness to study and explore more about the disease.
Glycolysis initially occurs through a sequence of enzyme-catalysed reactions in the cytosol of a yeast cell. High-energy carbon bonds in glucose are broken and the lower-energy molecule Pyruvate is formed. This produces enough energy to form ATP from ADP and Phosphate (Pi). NAD+ is reduced to form the coenzyme NADH:
Credibility Statement: Just like you, I am a college student. I too have to live with
Elderly & Healthcare Diabetes became a worldwide epidemic disease that is growing at alarming rates, resulting in high costs payed by our
In conclusion, diabetes is a serious disease and can be life threatening. With the right research and implementation of new studies diabetes can be reduced among the populations. We as a people need to realize this epidemic and all get together and beat it. Restaurants need to stop putting chemicals and unnecessary fats in their food. Not only diabetics but everyone should educate themselves on what is going in your body when you eat. Also, exercising and getting off the couch, in children, needs to be addressed and that alone would help reduce diabetes in the younger population. I can’t stress enough on education. If you know what you are eating or how you are exercising you protect yourself from poor health and live a great life. Type 2 diabetes can be dwindled down with a conscious individual and group effort.
Everyone has health care concerns, but health care concerns are higher for the 29.1 million people, or 9.3% of the population, living with diabetes right now, according to the American Diabetes Association. Diabetes, also known as diabetes mellitus, describes a set of metabolic diseases in which the person has high blood glucose because insulin production is insufficient, or because the body's cells do not respond correctly to insulin, or both. Prescription medication, doctor visits, insulin pumps, and diabetes counseling are only a couple of the things diabetics may have to pay for so being a diabetic can be extremely costly. Diabetes usually comes on fast and strong, not every patient can afford to pay for the care they need to control this