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Acid-base balance
Metabolic acidosis quizlet
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An acid base disorder is a change in the normal value of extracellular pH that may result when respiratory function is abnormal or when an acid or base load overwhelms excretory capacity. Acid base status is defined in terms of the plasma pH. The normal pH range level is between 7.35 and 7.45. Acidosis is a condition in which blood pH is below 7.35 and alkalosis is a condition in which blood pH is higher than 7.45. According to James L. Lewis, III, MD, “Acidosis and alkalosis are categorized as metabolic or respiratory, depending on their primary cause. Metabolic acidosis and metabolic alkalosis are caused by an imbalance in the production of acids or bases and their excretion by the kidneys. Respiratory acidosis and respiratory alkalosis are caused primarily by changes in carbon dioxide exhalation due to lung or breathing disorders.” …show more content…
This can cause asthma, COPD, pneumonia, or sleep apnea. The compensatory mechanism for respiratory acidosis is the kidneys hold on to bicarbonate/ HCO3. To be treated for respiratory acidosis you first need to find the underlining cause. Antibiotics, diuretics (to reduce pressure on the heart and lungs), bronchodilators (to expand the airways), and corticosteroids (to reduce inflammation) are some ways to treat this disorder. One way to lower your risk of getting this disorder is to stop smoking. Smokers are at higher risk for chronic respiratory acidosis. It increases the risk of respiratory diseases and can have an adverse impact on overall quality of
Most of the time, it is from smoking. The tissue in the lungs will become inflame and produce mucous because of exposure to these chemicals. Theophylline and ß2 agonist will act to relax and dilate the airways and allow more oxygen to enter. They will also decrease the lungs sensitivity so that they do not react so much to inhaled chemicals.
The effects of low pH, in guinea-pigs digestive tract, showed a similar effect to that of human lactase in a low pH environment. The pH levels tested in the guinea-pigs experiment were 2.5, 3.0, 3.5, and the control was 6.5. As the pH became
The kidneys play a major role in the blood composition and volume , the excretion of metabolic wastes in the urine, the control the acid/base balance in the body and the hormone production for maintaining hemostasis. The damages to the GBM in the glomeruli alter filtration process that allows the protein and red blood cells to leak into the urine. Loss of protein like albumin in the urine results in a decrease of their level into the blood stream. Consequently, this patient’s blood reveals a decreased albumin (Alb) value of 2.9 g/dL, decreased serum total protein value of 5 .0 g/dL and in the urine presents of the protein and the RBCs. Impaired filtering capacity result in inability of kidneys to excrete excretory products like electrolytes and metabolic waste products that will then accumulate in the blood. Furthermore, inability of distal convoluted tubules to excrete sufficient quantities of potassium, sodium, magnesium (Mg), chloride (Cl), urea, creatinine (Cr), alkaline phosphatase (Alk Phos), and phosphate (PO4) results in their elevation in the blood. His laboratory values reveal an increased of sodium value of 149 meq/L, an increase of potassium value of 5.4meq/L, increased chloride value of 116 meq/L, increased blood urea nitrogen (BUN) serum of 143 mg/dL, and increased creatinine serum of 7.14 mg/dL. The other abnormal blood tests associated with a loss of kidneys’ filtration property identify in this patient are related to an increase of alkaline phosphatase value of 178 IU/L, increased magnesium value of 3.8mgdL, and increased phosphate (PO4) value of 5.9 mg/dL .
The chemistry test shows the levels of electrolytes found in the blood: sodium, potassium, chloride, phosphorus, magnesium and calcium. Imbalances in these electrolytes can cause complications, which especially in the case of potassium, can be deadly. Also shown by the chemistry test, blood urea nitrogen and creatinine levels can show how well the patient’s kidneys are functioning in filtering waste from the blood. Trauma and blood loss can affect how the kidney’s function not only in filtering waste, but also in acid-base balance, and balancing electrolyte levels. Another marker of kidney function is the glomerular filtration rate, which measures the rate filtrate is created by the glomerulus of the kidney (Winkelman, 2016). This is controlled by the kidneys themselves, meaning changes in the function of the kidneys can lead to an altered filtration rate (Winkelman, 2016). Lactic acid is measured by the chemistry test also, and an increase in lactic acid can signify acidosis caused by the lactic acid being formed by cells that do not have adequate oxygen to process glucose for energy (Workman, 2016). This decrease in available oxygen could be caused by damage to or impairment of the lungs. Carbon-dioxide, which is also measured by the chemistry test, can show
The cause for the acid-base balance would be the sedative, the patient’s weight which is obese, respiratory, bicarbonate and metabolic problem.
Most substances fall on a scale ranging from the most acidic to the the most basic with neutral substances falling somewhere in the middle. Scientists call this the pH scale. pH levels are measured in numbers,0 to 14. The closer a substance is to zero the more acidic it would be. The closer to 14 the more basic a substance would be.Now what defines an acid and a base, one might ask? There are three ways of defining acids, each singling out a specific property. The first theory is the Arrhenius Theory with states, that an acid is a substance that produces the ion H+ when in a water solution, while a base is a substance which produces the ion OH- when in a water solution. Examples of an Arrhenius acid are HCl and HNO3. Examples of an Arrhenius base are NaOH and AlOH3.
The simple act of breathing is often taken for granted. As an automated function sustaining life, most of us do not have to think about the act of breathing. However, for many others, respiratory diseases make this simple act thought consuming. Emphysema is one such disease taking away the ease, but instead inflicting labored breathing and a hope for a cure.
The functioning of the chronic obstructive pulmonary diseases (COPD) is that it has a permanent decrease in the ability to force air out of the lungs. Consequently, it causes emphysema to become a more advanced disease with no cure. Emphysema is known for their permanent enlargement of the alveoli, which are accompanied by the destruction of the alveolar walls. The lungs lose their elasticity, so it loses its ability to recoil passively during expiration. People who have emphysema becomes exhausted fast because they need about fifteen to twenty percent of their body energy to breath which is more than what a healthy person needs. Smoking inhibits and destroys cilia in the conducting zone structures, which is the line of defense for the respiratory system.
Chronic bronchitis is a disorder that causes inflammation to the airway, mainly the bronchial tubules. It produces a chronic cough that lasts three consecutive months for more than two successive years (Vijayan,2013). Chronic Bronchitis is a member of the COPD family and is prominently seen in cigarette smokers. Other factors such as air pollutants, Asbestos, and working in coal mines contributes to inflammation. Once the irritant comes in contact with the mucosa of the bronchi it alters the composition causing hyperplasia of the glands and producing excessive sputum (Viayan,2013). Goblet cells also enlarge to contribute to the excessive secretion of sputum. This effects the cilia that carry out the mechanism of trapping foreign bodies to allow it to be expelled in the sputum, which are now damaged by the irritant making it impossible for the person to clear their airway. Since the mechanism of airway clearance is ineffective, the secretion builds up a thickened wall of the bronchioles causing constriction and increasing the work of breathing. The excessive build up of mucous could set up pneumonia. The alveoli are also damaged enabling the macrophages to eliminate bacteria putting the patient at risk for acquiring an infection.
strong acid or base does not necessarily yield a drastic jump in pH. The acid
One of the common diseases in the respiratory system that many people around the world face is emphysema or also known as chronic obstructive pulmonary disease (COPD). It is a chronic lung condition where the alveoli or air sacs may be damaged or enlarged resulting in short of breath (Mayo Clinic, 2011). If emphysema is left untreated, it will worsen causing the sphere shaped air sacs to come together making holes and reduce the surface area of the lungs and the amount of oxygen that travels through the bloodstream, blocking the airways of the lungs (Karriem- Norwood, 2012). The most common ways a patient can get emphysema are by cigarette smoking or being exposed to chemicals, dust or air pollutants for a long period of time. Common physical exams reveal a temperature of 100.8 Fahrenheit, 104 beats per minute, a blood pressure of 146/92, and a respiratory rate of 36 breaths per min (Karriem- Norwood, 2012). (see appendix A.1,A.2, A.3, A.4 for complete proof.)
Respiratory acidosis happens when the lungs can’t remove enough of the carbon dioxide produced by the body. Excess CO2 causes the pH of blood and other bodily fluids to decrease, making them too acidic. The body is able to balance the ions that control acidity. This balance is measured on a pH scale from 0 to 14. Acidosis occurs when the pH of the blood falls below 7.35. The normal blood pH level is between 7.35 and 7.45. Respiratory acidosis is typically caused by an underlying disease. The lungs take in oxygen and exhale carbon dioxide. Oxygen passes from the lungs into the blood and carbon dioxide passes from the blood into the lungs. Although, sometimes the lungs can’t remove enough CO2. This may be due to a decrease
An acid is a substance that produces hydrogen ions, H+ or hydrodium ionsH3O+ in solution. There are three “kinds of acids”: Arrhenius, BrØnsted-Lowry, and Lewis Acid. An Arrhenius acid is a substance the increases the concentration of hydrogen ion, H+ or hydronium ions H3O+when dissolved in water. You must have water. A BrØnsted-Lowry acid is any substance that donates a hydrogen ion, H+ to another substance. A Lewis acid is any substance that accepts a lone pair of electrons.A strong acid is one that breaks apart close to 100% when in solution (example HCl). When dissolved in water, HCl breaks apart into H+ and Cl- ions. Not all acids break apart. A weak acid is/are chemicals that do not break apart well. Acids have a sour taste, they are: corrosive and electrolytes. Acids react with active metals (group 1 or 2) to produce hydrogen gas, H2 They also react with bases to produce salt and water (a neutralization reaction). An Arrhenius base is any substance that increases the concentration of hydroxide ions (OH-) when dissolved in water. A BrØnsted-Lowry base is one that accepts a hydrogen ion, H+. A Lewis base is any substance that donates a lone pair of electrons. Bases have a bitter taste, bases react with acids to produce a neutralization reaction, and solutions that are basic feel slippery. On the pH scale, 7 is neutral. An acidic solution will have a greater hydrogen ion than hydroxide ion concent...
Acid-Base balance is the state of equilibrium between proton donors and proton acceptors in the buffering system of the blood that is maintained at approximately pH 7.35 to 7.45 under normal conditions in arterial blood. It is important to regulate chemical balance or homeostasis of body fluids. Acidity or alkalinity has to be regulated. An acid is a substance that lets out hydrogen ions in solution. Strong acid like hydrochloric acid release all or nearly all their hydrogen ions and weak acids like carbonic acid release some hydrogen ions.
... restore the neutrality by producing more alkaline urine, leading to an increase in their workload (Epstein, 1997). This increased workload can lead to different dysfunctions or renal collapse.