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Conclusion on bladder cancer
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Bladder cancer accounts for about 5% of all new cancers in the US. It is the fourth most common malignant cancer in men older than 60 years, but it is less common in women. The estimation for bladder cancer in the United States for 2017 are about 79,030 new cases of bladder cancer which about 60,490 in men and 18,540 in women. About 16,870 deaths from bladder cancer about 12,240 in men and 4,630 in women. These are significant numbers; however, the rates of new bladder cancers and cancer deaths have been dropping slightly in women in recent years. In men, incidence rates have been decreasing and death rates have been stable (American Cancer Society, 2017).
The Pathophysiology of Bladder Cancer
The exact causes of bladder cancer are unknown,
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Sometimes, there is enough blood to change the color of the urine to orange, pink, or darker red. Sometimes, the color of the urine is normal but small amounts of blood are found when a urine test is done because of other symptoms or as part of a general medical checkup. Other changes associated with bladder cancer are having to urinate more often than usual, pain or burning during urination, feeling as if need to go right away, even when the bladder is not full, or having trouble urinating or having a weak urine stream (CDC, …show more content…
Usually, urine tests are not used to make a specific diagnosis of bladder cancer because hematuria can be a sign of several other conditions that are not cancer, such as an infection or kidney stones. One type of urine test that can indicate the presence of cancer is cytology, a test in which the urine is studied under a microscope to look for cancer cells A bladder biopsy makes a definitive diagnosis. The imaging tests may be used to find out whether the cancer has spread. (American Cancer Society,
A 54 year old female was presented with complaints of lethargy, excessive thirst and diminished appetite. Given the fact that these symptoms are very broad and could be the underlying cause of various diseases, the physician decided to order a urinalysis by cystoscope; a comprehensive diagnostic chemistry panel; and a CBC with differential, to acquire a better understanding on his patient health status. The following abnormal results caught the physician’s attention:
Symptoms for urethritis are mild including frequency of urination and pyuria (presence of white blob cells in the urine). Cystitis (bladder infection) symptoms are easier to distinguish and include back pain, concentrated appearance, urgency, hematuria (presence of red blood cells in the urine), a...
The chemistry test shows the levels of electrolytes found in the blood: sodium, potassium, chloride, phosphorus, magnesium and calcium. Imbalances in these electrolytes can cause complications, which especially in the case of potassium, can be deadly. Also shown by the chemistry test, blood urea nitrogen and creatinine levels can show how well the patient’s kidneys are functioning in filtering waste from the blood. Trauma and blood loss can affect how the kidney’s function not only in filtering waste, but also in acid-base balance, and balancing electrolyte levels. Another marker of kidney function is the glomerular filtration rate, which measures the rate filtrate is created by the glomerulus of the kidney (Winkelman, 2016). This is controlled by the kidneys themselves, meaning changes in the function of the kidneys can lead to an altered filtration rate (Winkelman, 2016). Lactic acid is measured by the chemistry test also, and an increase in lactic acid can signify acidosis caused by the lactic acid being formed by cells that do not have adequate oxygen to process glucose for energy (Workman, 2016). This decrease in available oxygen could be caused by damage to or impairment of the lungs. Carbon-dioxide, which is also measured by the chemistry test, can show
Cancer is one of the 9 National Health Priority Areas (NHPA), areas which account for a significant portion of the burden of disease, but have sizeable potential for improvement. In Australia, CRC is the second most common cancer, after prostate (in men) and breast cancer (in women) (AIHW, Cancer incidence projections). The incidence has gradually increased (by 13% in males from 1982-2007) (AIHW, Cancer in Australia an overview). This is compounded by the ageing population and population growth, with 14,860 new cases in 2010 (http://www.cancer.org.au/about-cancer/types-of-cancer/bowel-cancer). This graph demonstrates this upward trend ((AIHW, Cancer incidence projections):
This can be investigated by a range of procedures. These include a CT scan of the kidneys and bladder in conjunction with an abdominal X-ray. Results obtained from the diagnosis and tests enable judgments’ relating to the stage to which the problem has developed and will inform decisions on the appropriate treatment
The underlying purpose of the experiments performed in the study, Promoter Hypermethylation of KLF4 Inactivates its Tumor Suppressor Function in Cervical Carcinogenesis, is to investigate the mechanism by which the KLF4 gene is silenced in cervical carcinomas. Cervical cancer accounts for 250,000 female deaths every year. Developing therapies for cervical cancer has been limited due to the lack of genetic and epigenetic data of the mechanism causing the cancer. The KLF4 gene is a transcriptional regulator of cell growth and differentiation. It functions as a tumor suppressor in cervical cancer, but is found to be inactivated in cervical cancer. The overexpression of KLF4 protein is known to inhibit cervical cancer cell growth and tumor formation by activating a cell cycle suppressor. Promoter CpG island hypermethylation can result in transcriptional silencing of many tumor suppressing genes. Two CpG regions, BSQ1 and BSQ3, were examined in this experiment.
Prostate cancer has been the number one diagnosed cancer today. According to the World Health Organization, approximately one in every ten American men will develop prostate cancer during his lifespan. This cancer has been very common in the last few years. American Cancer Society reported over 200,000 new cases of prostate cancer. Huge number of population suffered severely. The prostate is significant for reproduction. It helps the substances that are involved in fertilization and transporting of sperm as well as survival. Prostate tumor is developed in the prostate gland, which is found in the men’s reproductive system. Prostate is the size of a walnut, which is located inferiorly in the penis and anterior to the rectum. It contains the connective tissue, which includes the glandular and fibrous tissues. This tumor starts to develop during their adolescent year due to the control of the male reproductive hormones. When the tumor starts to develop, it begins at the urethra, which is a tube that releases the urine from the bladder. The tumor is a slow development yet it is contagious to the other parts of the body, such as it does affect the pelvic bones, lungs, liver, and the lower vertebrae (Zenka, 2009).
The University of Texas MD Anderson Cancer Center states the disease is divided into two major types namely acute and chronic. The acute types of the disease are those that progress quickly and involve an overgrowth of very immature blood cells. This becomes life threatening because very few mature cells mean that the body loses its ability to prevent infection, anemia and bleeding disorders. A diagnosis of the acute type is given when the immature cells found account for 20% or more of the blood cells produced. The chronic type progress slowly and involves an overgrowth of mature blood cells. In contract to the acute type people affect by this type usually h...
Being such, this disease can show small signs such as tingling in the fingertips, arms, and legs, temporary vision loss or red/ green discoloration, double vision, dizziness, and clumsiness. Sometimes the disease can skip the small beginner signs and show larger symptoms that are harder to dismiss such as, onset depression, inability to multitask, incapability to regulate bladder, fatigue mentally or physically, muscle spasms, and the inability to control one’s bladder. Signs and symptoms can occur over the course of one to ten days, and then disappear; this is known as an attack or
When cystitis is suspected, the doctor first examines the person abdomen and lower back, to evaluate unusual enlargements of the kidneys or swelling of the bladder. Tests doctor may order:
Genitourinary system: He doesn’t have pain during urinating and no increase of passing urine and he doesn’t need to get up in the middle of the night to pass urine. There is no blood in the urine.
Bladder cancer has been found in about 200,000 to 3,000,000 people per year. Bladder cancer occurs in the bladder of mainly older people. The bladder is a membranous sac in humans or other animals, where urine is taken in to be released. During bladder cancer, the cancer cells build up in the inside of the bladder. Cancer cells are cells that don’t respond normally to the cell cycle control system, making them reproduce rapidly. I would be interested in curing this cancer because the cancer is very common and can be very painful. Also, my grandfather had bladder cancer and was in a lot of pain, and once he was cured he felt a lot better. This makes me want to help everyone with this type of cancer so they are no longer in pain.
Uterine cancer is an important women health problem developing rapidly, killing over 200,000 women each year. No one has discovered the actual cause, but there is a leading factor that has great suspicions to what is causing this cancer to grow rapidly.
Blood and urine based biomarkers used in molecular pathology are only indicative of the average response of the cell population affected with little or no information of the range of response or variability form areas of tissue (Naddler and Langley 2001)