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Alzheimer's disease signs and symptoms essay
What causes alzheimer's disease essay
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Alzheimer’s is a horrible disease that takes the lives of many. There is someone diagnosed with Alzheimer’s around the world every seventy-two seconds. It is a form of dementia that slowly takes away the most basic of memories all the way to the memories of children, weddings, and even the saddest ones such as family death. The people that Alzheimer’s affects have a hard time with remembering tiny details and the disease begins with taking away the function of short term memory. This happens because the levels of acetylcholine are known to drop up to ninety percent beginning in the entorhinal cortex and moving into the hippocampus. Because of this, of the first signs of Alzheimer’s is the loss or decrease of the sense of smell, hence the entorhinal. The cells in the hippocampus called the hippocampal cells lose their connection and the result of this is the total loss of short-term memory. The neurons resting in the cerebral cortex then start to degenerate which in turn leads to the difficulty with the function of language and judgment. This also causes appetite to decline and then there is the loss of control over bowel movements. The disease will progress with many ending up not even recognizing their own children, much less being able to eat or bath or do simple tasks that they normally would not even have to think about.
Lack of acetylcholine is the main cause for loss of memory. In most people throughout the aging process, acetylcholine degenerates over time at a normal rate. In people affected by Alzheimer’s, acetylcholine degenerates at more than double the rate of people unaffected with this disease. Acetylcholine is a major neurotransmitter in the brain that allows communication of information from one nerve cell to an...
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...ther choline salt. Usually 500-2000 mg can be taken in three divided doses daily. Other supplements can also increase acetylcholine levels without increasing choline. Manganese taken 1-5 mg daily or Huperizine A is an herb that contains cholinesterase inhibitor.
Works Cited
http://neuroscience.uth.tmc.edu/s1/chapter11.html#storage http://www.uccs.edu/biology/alzheimers-disease.html http://www.ehow.com/about_6385188_happens-ach-may-cause-alzheimer_s_.html http://www.dementiatoday.com/biochemistry-of-alzheimers-disease/ http://web.williams.edu/imput/synapse/pages/IA5.html http://www.rcsb.org/pdb/101/motm.do?momID=54 http://www.alzheimers.org.uk/site/scripts/news_article.php?newsID=137 http://www.embo.org/news/research-news/research-news-2013/alzheimer-s-disease-protein-controls-movement-in-mice http://www.progressivehealth.com/cognitive-function-acetylcholine.htm
Labels on tryptophan supplements recommended a dosage of 500 to 1500 mg once or twice a day.
Alzheimer’s disease is a type of dementia that affects cognitive function in the elderly population. The exact cause of the disease is unknown but may include genetic as well as environmental factors. A progression of specific neurological changes allows the progression of the disease. Short-term memory losses along with dementia are typical symptoms of the disease. A definite diagnosis of the disease currently can only be confirmed by an autopsy. The disease progresses in five stages that will vary with every patient. There is no current acceptable treatment to reverse or stop the progression of the disease.
Thesis/Preview Statement – Alzheimer’s disease (AD) causes a decline in brain function, it destroys healthy nerve cells. Today, we have discussed Causes, Symptoms, and Diagnosis of AD.
Memory plays a significant role in the everyday lives of people of all ages. It allows them to recall information and remember skills that were learned in the past. Memory also organizes past information to help people make current and future decisions. However, imagine forgetting the names of close family members or not having the ability to find your keys every time you want to leave the house. These are some of the struggles that people with Alzheimer’s disease face daily. Alzheimer’s disease was first identified by German neurologist Alois Alzheimer in 1906, and was discovered to have an overpowering effect on explicit memory loss (Gruetzner, 1988). There are two types of Alzheimer’s disease – early onset and late onset. Early onset occurs in patients who are diagnosed before the age of 65 whereas late onset occurs in patients who are diagnosed after the age of 65. In the early stages of Alzheimer’s disease, short-term memory is often lost. As Alzheimer’s disease progresses, problems with long-term memory begin to develop, in addition to short-term memory impairments. Although a lot is known about the symptoms of Alzheimer’s disease, the cause has not been conclusively identified. However, as research continues, new theories about the cause of Alzheimer’s disease are being proposed. This has led to a controversy over whether Alzheimer’s disease is caused by genetics or environmental influences (Gruetzner, 1988).
Alzheimer’s disease is a complex illness that affects the brain tissue directly and undergoes gradual memory and behavioral changes which makes it difficult to diagnose. It is known to be the most common form of dementia and is irreversible. Over four million older Americans have Alzheimer’s, and that number is expected to triple in the next twenty years as more people live into their eighties and nineties. (Johnson, 1989). There is still no cure for Alzheimer’s but throughout the past few years a lot of progress has been made.
The well-known poison botulin works by blocking acetylcholin, causing paralysis. The botulin derivative botox is used by many people to temporarily eliminate wrinkles --a sad commentary on our times, I would say. On a more serious note, there is a link between acetylcholine and Alzheimer's disease: There is something on the order of a 90% loss of acetylcholine in the brains of people suffering from that debilitating disease.
Alzheimer’s is a progressive, degenerative disease of the brain and individuals with the disease suffer from many symptoms such as memory loss, agitation, impaired judgment, and difficulty communicating with others. The different lobes affected include the parietal lobe which deals with language, temporal lobe which deals with memory and frontal lobe which deals with behavior and judgment. The specific type of memory loss that an Alzheimer’s patient deals with is declarative memory. Declarative memory is remembrance of facts such as people’s names, what their faces look like and important dates from our past (Marieb and Hoehn 2013). The formation of these memories can only happen when the temporal lobe or more specifically the hippocampus are able to receive acetylcholine inputs. Patients with Alzheimer’s loose this input which prevents making new memories and remembering old ones (Marieb and Hoehn 2013).
Alzheimer’s is a disease that many people have heard of, but few really know much about. Imagine not being able to remember your loved ones and friends or even how to do simple tasks like dressing yourself and brushing your hair. Now imagine having to dress your mother, who rarely remembers you anymore. This is the reality of life for millions of older people afflicted with Alzheimer’s disease and the families that care for them. Alzheimer’s causes cognitive function to decrease gradually overtime. Alzheimer’s disease is the most common form of dementia - affecting around 5 million Americans (alz.org). It is the most fatal disease affecting older people and needs to be taken seriously.
Cummings, Jeffrey L., Cole, Greg. “Alzheimer Disease.” Journal of the American Medical Association. May 2002: 287-18. Health Source. EBSCOhost. Utica College Lib. 15 Apr 2005. .
Dementia is the progressive deterioration and impairment of memory, reasoning, and other cognitive functions occurring as the result of a disease or condition. Dementia can affect the person’s ability to carry out daily activities. For example, the person may forget where they live or they might think they have already done their activities but never did. Dementia can also cause the elderly to become incontinent and can’t control their urinary system. Many people get confused that dementia is a disease. Dementia is not a disease. However, it can lead to a disease or condition. Dementia is more common in the elderly population. It’s normal for people to forget things, but to a certain extent it becomes a critical issue. Depression also plays a role in the affects of dementia. Studies have been made to believe that the biological mechanisms for depression relating to dementia is, “interactions with vascular diseases, changes in glucocorticoid steroid levels that can result in hippocampal atrophy, accumulation of amyloid-[beta] plaques, inflammatory processes, and lack of nerve growth factors” (Heser et al., 2013). Dementia is caused because of plaques and neurofibrillary tangles. This can also be known as Alzheimer’s Disease. Dementia is the leading cause for Alzheimer’s Disease in the elderly. For all dementia cases, 60 to 80 percent of people with dementia will have Alzheimer’s Disease. The disease has 3 different stages, the early stage, the middle stage, and the late stage. Each of those stages has a variety of symptoms that affects the memory impairment of the person (Wieregna, Bondi, 2011). Also relating to dementia is Parkinson’s Disease and Huntington Disease. These diseases can result in impairment, which can cause challeng...
Alzheimer’s disease is a form of dementia which is a brain disorder that impairs mental functioning. Dementia attacks the part of the brain which controls memory, language, and thought. It makes everyday tasks like remembering to brushing your teeth, or to pay your bills next to impossible to do, which is why so many people who are diagnosed with this disease are in complete care. This disease has different phases, the first being slight forgetfulness and then the persons emotions may heighten as well as language impairment, violent outbursts, loss of bladder control and from there it keeps getting worse until complete dysfunction of the brain occurs and eventually death, which most of the time is the result of infection.
Alzheimer's disease is a neurological disorder which kills the brain cells, causing memory loss and cognitive decline. This leads to severe psychological impairments which changes how people think, behave and other complications such as paranoia, disorientation and unprovoked aggression. These psychological impairments reduce people’s functional ability and therefore reduce their quality of life.
Alzheimer’s disease is a neurodegenerative disease that attacks and destroys brain nerve cells or neurons eventually killing the cells. It is the most common form of dementia (around 50-60% of all cases of dementia). it affects 1 in 20 people over the age of 65 and 1 in 1000 people under the age of 65. Although it affects more people over the age of 65 it doesn’t mean that age is the cause of the disease. Patients suffering from Alzheimer’s disease suffer from memory loss, thinking difficulty, loss of language skills and changes in behaviour. No one is immune to this disease. Alzheimer’s disease is named after Dr Alois Alzheimer’s. In 1906 he noticed changes in the brain tissue of a woman who died from an unusual mental illness. Her symptoms included loss of memory, language problems and unpredictable behaviour. After her death he examined her brain and found abnormal protein fragments called plagues and tangles. These protein fragments are the two major features of Alzheimer’s disease. The third is the loss of connection between nerve cells and the brain.
So, as we can see here synaptic loss is not just age related and we can see this relationship through the evidence of the parts of the brains affected as well as a study that looks at an actual comparison of synapses. The comparison is between people with no cognitive impairment, mild cognitive impairment, and early Alzheimer’s disease. Mild cognitive impairment is a type of impairment within the brain that can cause a slight but noticeable decline in cognitive abilities. These abilities include memory and thinking skills. These patients are at a higher risk of developing Alzheimer’s and that is why they were also looked at in this research (Scheff, Price, Schmitt & Mufson, 2005). One of the major research findings that led to this study was that patients with Alzheimer’s disease seemed to have a loss of synaptic contacts in their neocortex and hippocampus. This loss of synaptic contacts demonstrates an association with cognitive ability and correlates strongly with dementia. It was unknown whether patients with mild cognitive impairment had significant synaptic loss compared to those with no cognitive impairment.
Alzheimer’s Disease is formed in the brain but yet, has no known cure or treatment. Alzheimer’s Disease has many symptoms. Memory is the biggest symptom along with mood swings and having a hard time with keeping a conversation. A patient with Alzheimer’s goes through 7 stages; The first stage, which is misplacing things or forgetting what something is used for, second stage, they start losing more of their memory and they begin to forget where they are or what they are doing, the third, fourth and fifth begin to mentally decline and need someone to take care of them and worsen over time.The sixth stage they begin to have an even more difficult time going to the bathroom and cleaning themselves or using electronic devices such as phones or televisions. The final stage, at which the long goodbye comes to an end, they now are mentally and physically gone. Some doctors prescribe medication to the patients to help deal with some of the symptoms.