Actifed Expectorant Case

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The name of the over-the-counter medication is Actifed Expectorant. Actifed Expectorant contains 1.25 mg Triprolidine HCL, 30mg Pseudoephedrine, and 100 mg Guaiphenesin HBr. All 3 of these ingredients are per 5mL syrup. The dose quantity and spacing as indicated on the product is 10 mL syrup 3 times a day, or 8-hourly. The label indicates that Actifed Expectorant is used to provide symptomatic relief of upper respiratory tract disorders accompanied by productive cough, which benefit from the administration of a nasal decongestant, a histamine H1-receptor antagonist, and an expectorant combination. The rationality of the product and its combination will now be discussed. The criteria used in order to gauge the safety and effectiveness of the medication …show more content…

6 The ingredients are present at active dose levels. The comparisons of the dosage and dose spacing for each ingredients have been tabulated: Ingredient Recommended dose and spacing (according to MIMS and APF) Dose and spacing indicated on product information leaflet 4 Triprolidine HCL 2.5 mg 4-6 hourly 2.5 mg 8 hourly Pseudoephedrine HCL 60 mg 4-6 hourly 60 mg 8 hourly Guaiphenesin 200-400 mg 4 hourly 200 mg 8 hourly Table 3 The dosage indicated on the product leaflet matches the recommended dose. However, there are mismatches between the dosing intervals. It can be seen that the doses are spaced too far apart (8 hourly) in comparison with the recommended dose spacing intervals (4-6 hourly). A recommended dosing interval would be 6 hourly. Upon rectifying, the new dose would be 10 mL Actifed Expectorant syrup 4 times a day, or most specifically, every 6 hours. This not only bears a closer resemblance to the literature dosage, it still falls within the maximum daily dose: Ingredients Maximum daily dose in literature Maximum daily dose after alteration (i.e every 6 hours) Triprolidine 10.0 mg 1 10.0 mg Pseudoephedrine 240.0 mg 5 240.0 mg Guaiphenesin 2400.0 mg 6 800.0 mg Table

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