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Cyclic Voltammetry in Electrochemical Method
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Cyclic Voltammetry is an electrochemical method used to study electrically active species. The basic theory behind cyclic voltammetry is that the species being studied undergoes excitation viva a potential. The potential is cycled between two points. Cyclic voltammetry can be used to study kinetics, mechanisms, synthesis, and quantitative analysis. In the following experiment, cyclic voltammetry will be used to study the concentration of acetaminophen in children’s pain reliever. The analysis of the elixir concentration was found to be 28.1 mg/L; given that the specified concentration was 32 mg/L. The percent error of the analysis was found to be 12.1 %. Introduction: Electrochemistry is a large branch in the disciplines of chemistry. Within electrochemistry, cyclic voltammetry is a method in which compounds undergo reduction and oxidation. Cyclic voltammetry (CV) offers methods in acquiring kinetic information, synthesis, mechanisms, and quantitative information about a species, reactions, or a compound. Cyclic voltammetry offers methods in …show more content…
Acetaminophen is a replacement pain reliever for children, due to aspirin side effects. The redox of acetaminophen is an irreversible, however, this under conditions where the pH is acidic. Acetaminophen is reduced to N-acetyl-4-quinoneimine. Due to acidic conditions, it is rapidly hydrolyzed to N-acetyl-4-quinoneimine hydrate, which cannot be forced back to acetaminophen. In order to overcome this, the analysis is done in a neutral or basic buffer. This prevents N-acetyl-4-quinoneimine from being hydrolyzed and allows it to be oxidized back to acetaminophen1. Acetaminophen under a neutral environment becomes a quasi-reversible system. Since not all of the N-acetyl-4-quinoneimine can be prevented from forming the hydrate, the data will contain errors. The amount of acetaminophen stated on the children’s Tylenol was 160 mg per 5
Everything from the kinetics of second order decomposition reactions to the electromotive force of the redox reactions in a voltaic cell. I soon discovered my interest to work in a lab setting from this class. I aspire to be part of this program to further my knowledge of the laboratory, including new procedures and
“Chemistry is the study of substances; their properties, structure, and the changes they undergo” (Lower). Chemistry is the study of all the stuff in the world and especially how they change. My experiment deals mostly with the change of substances. Some of the concepts involved in my experiment are Oxidation/Reduction (redox) reactions, electrolysis, pH, and electrical currents. A redox reaction is a reaction in which there is a transfer of electrons from one substance to another. There are two paired parts to a redox reaction: the oxidation and the reduction. The oxidation is the loss of electrons while the reduction is the gain of electrons. They always occur together because one substance has to receive the electrons that another substance is giving up. Electrolysis is a process where electricity goes through a liquid, which causes chemical reactions to occur. pH is the measure of how acidic or basic something is. More exactly, it is, at least indirectly, the number of hydrogen ions there are in a liter of solution. A hydrogen ion is a hydroge...
Oral acetaminophen is rapidly absorbed from the stomach and small intestines. The serum drug concentration peaks 1-2 hours once after ingestion. Peak plasma level occurs within 4 hours of post ingestion of over dose of an immediate release preparation. Therapeutic levels are 5-20 µg/ml. Acetaminophen primarily metabolized by liver to non toxic, water soluble form that is eliminated in the urine. Overdose leads to formation of hepatotoxic reactive metabolite causes an ensuring cascade of oxidative damage and mitochondrial dysfunction. This subsequent inflammatory response propagates hepatocellular injury and death. Similar enzymatic reaction occurs i...
The invention of aspirin, a medical-breakthrough, mainly belongs to the knowledge of chemistry. In order to study how aspirin actually work and its possible side-effect, pharmacology knowledge is also needed.
Rajagopal, Indira, and S.R. Rajangopalan. "Electrochemical Preparation of Potassium Gold Cyanide." Bull. Mater. Sci. 6.2 (1984): 165-75. Web. 14 Nov. 2013.
A common over-the-counter medication for symptoms such as headache, stomach ache, and heart burn is Alka-Seltzer tablets.1 One of three ingredients found in the tablets is acetyl salicylic acid (C8H12O4) to relief head ache pains. The other two components are sodium bicarbonate (NaHCO3) and citric acid (C6H8O7) which are utilized under the acid-base chemistry rule in order to produce the fizzing sensation needed to produce excess CO2 to aid in heartburn and stomach aches.1 The Brønsted-Lowery Acid-Base Rule simply states properties of both types of substances and how they will react with when added to a solution. A base will accept a proton donation while an acid will donate the proton.2 Utilizing all of this information an experiment was conducted
The purpose of this lab was to determine the concentration of an unknown copper solution using galvanic cells and the flow of electrons from chemical energy into electrical energy. Our hypothesis was that using the oxidation/reductions reaction in a galvanic cell that occur from the transfer of electrons, we would be able to determine the concentration of an unknown copper solution. In order to do this, Lab 10 was broken up into three sub-labs referred to as Lab 10A, Lab 10B, and Lab 10C, respectively. In Lab 10A, the objective was to determine the reduction potential for iron. This was done by submerging different
Equal amounts of fifty milliliters of hydrochloric acid and sodium hydroxide were obtained. The fifty milliliters of hydrochloric acid was added to the Erlenmeyer flask containing the antacid. The flask was swirled to allow the samples to completely dissolve. Approximately three drops of the bromocresol green indicator was added to the solution in the Erlenmeyer flask. The solution then turned urine yellow in color. A buret was obtained and cleaned out with deionized water to eliminate any remnants. The fifty milliliters of sodium hydroxide was then poured into the buret and the initial amount was recorded from the buret. The sodium hydroxide was then gradually titrated into the Erlenmeyer flask. With each drop of sodium hydroxide the flask was swirled to allow the solution to mix. The sodium hydroxide was added until the urine yellow solution in the flask turned a sea foam green color to detect the
The instructions created by our group were followed, although there were necessary changes made. Instead of using litmus paper to determine the pH of the substance, we used the universal indicator liquid. In terms of errors made, we failed to correctly test the conductivity of certain compounds. We were unable to recognize that we cannot test the conductivity in water if the compound did not dissolve in water.
There was a feud between feminists who wanted flibanserin regardless of the side effects, and FDA who believed the approval for safety of flibanserin was an elongated process. This paper will explain the six reasons why flibanserin had been mistakenly approved by FDA.
One significant advantage of capillary electrophoresis (CE) is the separation of a broad range of analytes at the same moment. Affinity Capillary Electrophoresis (ACE) is a technique used in order to separate substances which participate either in specific or in non-specific affinity interactions during the electrophoresis process, by using a capillary electrophoresis format. The molecules can be free in solution or they can be immobilized to a solid support (Heegaard, Nilsson and Guzman, 1998).
Electrodes: Are thin sheets of 6mm in length of pure-self annealed aluminium foil. Two electrodes are used in every single-phase capacitor. One electrode is positively charged, while the other is negatively charged.
In H. A. Laitinen’s thesis, he detailed new processes used for analyzing new evidence with electroanalytical chemistry: “Electroanalytical chemistry since 1950 has moved in several directions, including (a) ion selective electrodes, (b) other electrochemical sensors, and (c) combinations of electrochemical and optical techniques.” Electroanalytical chemistry is a form of chemistry involving electrical current, which can be measured using two different ways, potential (volts) and current (amps) (Chapter 22-Introduction to Electroanalytical Chemistry). This was a major breakthrough in the field as it made the process more reliable and the analysis was completed in a faster time. As the 1960s approached, ion selective electrodes were starting to be utilized. Ion selective electrodes selectively respond to different ions in the presence of different ions, these measure the gases and ions that are in a solution. The pH probe is the most common of all of the ion electrodes. Some other ion electrodes can include fluoride, cadmium, and bromide. These electrodes are used to determine different substances that are dissolved in solution. While gas chromatography was discovered in the early 1940s, it was not published until 1948, after World War II. The discovery was not widely accepted or acknowledged until the
Gusdinar T. COMPLEXOMETRIC TITRATION An application method of Inorganic Pharmaceutical Analysis [homepage on the internet] . No date. [cited 2014 Mar 20]. Available from: http://download.fa.itb.ac.id/filenya/Handout%20Kuliah/Inorganic%20Pharmaceutical%20Analysis%202008/English%20Version/05.%20COMPLEXOMETRIC%20TITRATION.pdf.
Conductivity is found out by measuring the AC resistance of the solution between two electrodes. Dilute solutions follow Kohlrausch's Laws of concentration dependence and additivity of ionic contributions. A theoretical explanation of Kohlrausch's law by extending the Debye–Hückel theory was given by Lars Onsager.