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The aim of present study was to examine the effects of long-term/exhaustive exercise and spirulina intake on plasma, liver and muscle tissues’ oxidative state in adult male rats. We found that the exhaustive exercise resulted to increased levels of CK, CK-MB and LDH in the plasma of E group. An important finding of our study is that spirulina attenuated exhaustive exercise-induced CK increment in the plasma. Additionally, spirulina supplementation and acute or chronic exercise changed antioxidant status and oxidative stress parameters. MDA which is an end-product of lipid peroxidation decreased with both spirulina supplemented and chronic exercised rats in liver and skeletal muscle. We observed that the most important effects which are related to the oxidative stress are associated with adaptational responses that are linked to regular exercise.
Although influences of the exercise on metabolism is well-defined, weight gain of rats were not different than control rats. This finding is in concordance with previous studies (barcelos24334002, lima23405192). Though, it can be suggested that swimming exercise has not major impact on the weight of rats, probably due to exercise intensity and duration. Also, 750 mg/kg/day, pospirulina supplementation for 6 weeks did not altered the weight of rats when compared with control animals. We could not find any study in the medical literature which reports direct effects of spirulina on the body weight. Howbeit, there are several researches which point out how the spirulina influences the weight (ismail19521547, khan16858688, moura21569626) that are in consistency with our findings. So in sum, it can be deduced that spirulina supplementation has no effect on the weight of rats.
Moderate exercise ...

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...688) and gentamisin-induced (Kuhadve ark 2006- 16573712) oxidative stress in kidney tissue.
Conclusively, we suggest that spirulina platensis, a blue-green algae and a food supplement, ameliorates plasma CK activity which is used as an exhaustive exercise related muscular breakdown indicator, probably by decreasing pre-oxidative MDA levels in the skeletal muscle. However, it is apparent that spirulina supplementation to adult male rats has no positive effect on antioxidant activity and ergogenic status in our exercise protocol. There are few studies which investigates effects of spirulina supplementation to exercise-induced oxidative stress and exercise endurance capacity, and the action mechanism of spirulina on oxidative stress during exercise processes are not yet well understood whereas future studies is needed in this area to have a satisfactory comprehension.

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