Solubility is defined as the greatest amount of a solid, liquid or gaseous chemical substance that will dissolve in equilibrium in a specified volume of solid, liquid or gaseous solvent at a particular temperature or pressure to form a homogenous solution. Meanwhile, dissolution is a process whereby the solid chemical substance is dissolved in the solvent to form a solution.
IUPAC Compendium of Chemical Terminology, 2009 defines solubility as the proportion of a specific solute in a specific solvent which can also be explained as the analytical composition of a saturated solution. Solubility can also be expressed as the concentration, molality, mole ratio and mole fraction.
Solubility is one of the important physicochemical properties affecting the bioavailability of a drug. Bioavailability is the rate and extent of drug absorption. Hence, the drug must first be in solution or solubilized so they can be absorbed to achieve the desired pharmacological response. Solubility is a critical factor if the
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Food and Drug Administration. This system restricts the prediction using the parameters solubility and intestinal permeability.
Solubility is based on the highest-dose strength of an immediate release product. A drug is considered highly soluble when the highest dose strength is soluble in 250 mL or less of aqueous media over the pH range of 1 to 7.5. The volume estimate of 250 mL is derived from typical bioequivalence study protocols that prescribe administration of a drug product to fasting human volunteers with a glass of water. A drug substance is considered highly permeable when the extent of intestinal absorption is determined to be 90% or higher. Otherwise, the drug substance is considered to be poorly permeable. (Yu et al., 2002)
Table 1. Biopharmaceutics Classification System (BCS) with characteristics of drugs.
BCS class
A mixture, according to definition, is a combination of components and substances mixed together to form one particular substance, uniform or not. Mixtures can be classified down to two types, homogeneous and heterogeneous. Homogeneous mixtures are generally uniform, or have the same consistent composition throughout, whereas heterogeneous mixtures are not entirely defined and vary in
The analysis is therefore one of the most effective methods of ensuring that each drug being prescribed to patients is safe. It also ensures that all drug components are understood in terms of their structure and chemical behavior. This understanding is very important in the manufacture of drugs and other pharmaceutical products.
...clearance and volume of distribution of unbound drug increased after post menstrual age with an increase of 41% and 25% of mature values respectively. The terminal half life decreased with an increase in age. This could be accounted for by differences in body weight and increase in metabolising enzymes as the subjects mature. Ropivacaine metabolism occurs by 1st order kinetics to PPX. the fraction metabolised utilised PPX urinary amounts. Post menstrual age and body weight were required in the expression of clearance, only body weight was required for the expression of volume. Clearance of unbound PPX achieved half of its mature value at 46.5 weeks post menstrual age. There was an increase of fraction metabolised in coloured and mixed race groups aged less than 1 year. The effects of increased volume and clearance are minimal as the metabolite in excreted anyway.
Precision of a patient’s intravenous medication is essential; it must be safe from. contamination, toxicity, and side effects. Most people believe these medications are compounded or mixed by a trained and licensed individual. However, this is inaccurate because the pharmacy technician actually compounds a large percentage of a patient’s medications. Compounding involves a technician’s math skills, aseptic technique, and professional ethics.... ...
Pharmacokinetics provides a basis to assess the course of drugs and their effects on the body (Dhillon & Kostrzewski, 2006). The processes of pharmacokinetics can be broken down into the absorption, distribution, biotransformation, and excretion in, through, and out of the body. These are major concepts that guide medication use and dosage selection (Association of Surgical Technologists, 2017).
When administering medications it is critical to pay great attention to the task at hand. This task becomes more important when administering medications to the elderly because of the different physiological and psychological changes that occur in the body. Equally important are, the lab values related to the medications being administered, differences in administering medications to the elderly, and the use of the six rights and three checks.
“Pharmacokinetics (PK) and pharmacodynamics (PD) can be seen as two sides of the same coin. PK and PD have a definite relationship, assessing how much drug gets to the site of action and then what that action is. Both activities are essential in the complete investigation of the interaction between the drug and body, and play significant roles in both drug development and their continual use in the clinical setting (Institute Of Clinical Research, Clinical Pharmacology Special Interest Group, Pharmacokinetics vs. Pharmacodynamics).”
To continue, compounding would be needed if a patient wants to change something about the medicine such as flavor or strength. It is vital that s...
In 2004, the United States Pharmacopeia put into place strict rules and regulations to govern aseptic preparation (Johnston,12). These regulations cover areas like: facility design, microbial contamination risk levels, personal training, atmosphere of the clean room, proper dress, and quality assurance (Johnston,12). A part of all this is to prepare the medications in germ free conditions, especially if the medication in question is going to be given intravenously (Johnston,12). USP 797 helps provide a safer environment for the production of sterile compounded medication to help save lives (Johnston,12).
Leonard G.S., Tovey G.D., Lee R.M., (1979) The Pharmaceutical Development and Bioavailability of Cimetidine Capsule and Tablet Formulations, DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 5 ( 2 ) , pp 217-226.
Solubility is the capacity of a substance to break down. During the time spent dissolving something, there is a solute and a solvent. The substance that is being disintegrated Known as solute and the substance that is doing the dissolving Known as Solvent. For instance, sugar is said to be a solute and water is a solvent . With this idea, solubility can be comprehend on a more particular level. Solubility is known not the most extreme measure of solute that can be disintegrated in a solvent at harmony. Equilibrium is the point at which the convergences of items and reactant have ended up equivalent after the response has occurred.
...sed. Usually, the criteria adopted for addition of medications in formulary ; proven results of that medication about effectiveness and efficiency ;
Vitamin B and C are water-soluble vitamins which mean that they can be dissolved in the presence of
The rate of reaction is how quickly or slowly reactants in chemical reactants turn into products. A low reaction rate is when the reaction takes a long time to take place; hence, a reaction that occurs quickly has a high reaction rate. A rate refers to how slow or quick the product is produced. It is possible to control the rate of chemical reactions and speed up or slow down the rate of chemical reactions by altering three main factors which are temperature, concentration and the surface area. When the temperature of the reactants increases, the molecules vibrate at a more intense speed therefore colliding with each other more frequently and with increased energy resulting in a greater rate of reaction. Accordingly, as the temperature decreases the molecules will move slower, colliding less frequently and with decreased energy resulting in the rate of reaction decreasing. Concentration is how much solute is dissolved into a solution and is also a factor that affects the rate of reaction. When the concentration is greater this means there is an increased amount of reactant atoms and molecules resulting in a higher chance that collisions between molecules will occur. A higher collision rate means a higher reaction rate. Consequently at lower concentrations there are reduced chances of the molecules colliding resulting in a lower reaction rate. The measurement of how much an area of a solid is exposed is called the surface area. The quicker a reaction will occur the more finely divided the solid is. For example, a powdered solid will usually have a greater rate of reaction in comparison to a solid lump that contains the same mass for it has a lower surface area than the powdered solid.
Pharmacokinetics is one of the two subsections of pharmacology, the other being pharmacodynamics. It studies the processes of Liberation Absorption, Distribution, Metabolism and Excretion of a chemical compound. Pharmacokinetics allows for mathematical practises to be applied to the four processes, and quantify and therefore assess the effect the concentration of a drug has on the body over time. The five parameters of Liberation Absorption, Distribution, Metabolism and Excretion (LADME for short) are responsible for the changes in concentration of a drug in the body, theory stands that the magnitude of the response requires, and depends on, the concentration of the drug in the fluid the is bathing the target tissue. A deep understanding of these processes is vital in order to provide the correct chemical therapy for a patient.