WILL PHUQ: The Arylcyclohexylamine

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WILL PHUQ - 'KETAMINE-RELATED: THE ARYLCYCLOHEXYLAMINES'
Ketamine numbers many relatives in the arylcyclohexylamine class (of which it is itself a member), although not all are dissociative in effect, or indeed pharmacologically active. Arylcyclohexylamines are useful tools for chemists and pharmacologists, due to their application in research on NMDA receptors, dopamine reuptake inhibitors, and opioid receptors. Other (unrelated) chemical classes with dissociative effect include Adamantane/ memantine, L-Arg, APV, Opioids, peptides, and simple gases.
With the explosion in popularity of ketamine (and latterly it’s cousin methoxetamine) across the UK’s recreational drug scene over the last decade, it seems logical to at least briefly delve …show more content…

It is often used medically alongside eticyclidine, in combination with which it acts as a prodrug – metabolising into a more pharmacologically active substance.
Eticyclidine (PCE, CI-400)
PCE is a less common (though still controlled) dissociative, similar in effects to PCP, yet a little more potent. First developed in the 1970s by Parke-Davis, as an anesthetic (under the name ‘CI-400’), research was discontinued subsequent to the development of ketamine, due to its perceived attractiveness over that of PCE. Rarely encountered in the modern recreational drugs scene, although briefly abused throughout the 1970s and 1980s (when users reportedly soon learnt to loathe the drug’s smell, taste, and nausea-inducing properties).
Methoxetamine (MXE, MKET, Mexxy/Mexi, Minx, Jipper, 3-MeO-2-Oxo-PCE)
Allegedly first synthesized circa 2010, by an underground arylcyclohexylamine chemist looking for “… something fantastic … the perfect dissociative … a stress-free version of ketamine”. MXE did not undergo any legal medical trials before entering into the illegal market, and should not be confused with its cousin Methoxyketamine, or 2-MeO-2-deschloroketamine. Until an April 2012 Temporary Class Drug Order (TCDO) by the government, no license was required in the UK to buy, sell or otherwise utilise MXE; however, in November 2012 it was classified as a Class B …show more content…

In 1965, human use was discontinued due to PCP’s strongly dissociative effects, resulting in an increase in clandestine laboratories producing the drug. Often demonised as basically turning users into unstoppable and violent psychotics, today PCP is rarely used as a veterinary medicine, yet is an infrequent but definite presence on the fringes of the black markets. It is active via most traditional routes of ingestion, with a tendency toward more euphoric/ less anesthetic effects when insufflated.
Rolicyclidine (PCPy)
Rolicyclidine is similar in effect to PCP, but with a lesser tendency towards stimulation, instead producing a sedative effect reportedly “somewhat similar to a barbiturate, but with additional PCP-like dissociative, anesthetic and hallucinogenic effects”. PCPy has never been widely available to the drug-using public, and as of the time of writing is seldom seen on the black market.
Tenocyclidine (TCP,

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