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Tissue Repair and Regeneration
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Skeletal, smooth, and cardiac muscles play a vital role in the everyday processes that allow the human body to function. Without these muscles, everyday tasks and functions could not be conducted. Injury to these muscles could cause serious problems, however, these muscles have the ability to regenerate, repair, and fix multiple problems all by themselves. Repair and regeneration of a muscle are two similar, yet different things. Repair restores muscle continuity so that it can continue to function in the same way as before injury, but does not completely restore the pre-injury structure like regeneration (Huijbregts, 2001). Muscle repair and regeneration take place after an injury, after surgery, after atrophy, and even after working out.
Repair after a muscle is damaged happens through the division of certain cells who then fuse to existing, undamaged muscle fibers to correct the damage. Different muscle types take different amounts of time to heal and regenerate after it has been damaged. Smooth muscle cells can regenerate with the greatest capacity due to their ability to divide and create many more cells to help out. While cardiac muscle cells hardly regenerate at all due to the lack of specialized cells that aid in repair and regeneration. In skeletal muscle, satellite cells aid in helping restoration after injury. Along with muscles, tendons are very important structures within the human body, and they to can be damaged. However, tendon repair involves fibroblast cells cross-linking collagen fibers that aid in not only reinforcing structural support, but also mechanical support as well (“Understanding Tendon Injury,” 2005). While quite different from muscle repair, tendon repair involves the similarity of reestablishing d...
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Tendinopathy is a generic description that encompasses many pathologies of clinical conditions arising from chronic overuse in and around the tendon such as ruptures/tendinitis, tendinosis and paratendinitis, which can only be classified post histopathological examination (Maffulli, Sharma, & Luscombe, 2004; Khan, Cook, Bonar, Harcourt, & Astrom, 1999). There has been a shift to replace the pathological term ‘tendinitis’ with ‘tendinosis’ as increasing research fails to detect the presence of prostaglandin mediated inflammatory cell infiltration within the pathological tendon (Khan, Cook, & Kannus, 2002; Khan et al. 1999). Achilles tendinosis pathology is now attributed to a failure of the cell matrix to adapt to repetitive trauma. With fiber disorientation, ...
Scibek, J. S., Gatti, J. M., & Mckenzie, J. I. (2012). Into the Red Zone. Journal of Athletic Training, 47(4), 428-434.
“What are the potential uses of human stem cells and the obstacles that must be overcome before these potential uses will be realized?” . InStem Cell Information. Bethesda, MD: National Institutes of Health, U.S. Department of Health and Human Services, 2009.
Muscular Dystrophy is a diverse group of disease which involves the weakness and wasting of muscles and leads to many other problems in physiological system. It is because of mutation in gene related to contraction and relaxation of muscles. Although recently no perfect treatment option is available for it but in nearby future cure of this disease will be available due to advanced technology and methods like gene therapy and stem cell technology.
New cells are often produced in the body during growth and development. In addition, new cells also develop as the body repairs and remodels its tissues after an injury. These new cells come from mesenchymal stem cells (MSCs), which are considered as multipotent cells. MSCs are found in various parts of the body during growth and development, but in adults, they are present in the bone marrow, where they later differentiate, mature and migrate to become more specialized cells with unique functions. These cells' potential to develop into bone cells, cartilage cells, muscle cells and fat cells makes their role in regeneration, repair and remodelling important, especially when the body undergoes the normal process of aging or recovers from disease or injury.
This report does a fairly comprehensive job on educating the public to the definition of stem cells, describing them as “a diverse group of remarkable multipotent cells that are relatively undifferentiated and unspecialized cells of the body.” Stem cells have the capacity for unlimited self-renewal and the possibility to produce differentiated descendant cell types. The main in...
People have created a hectic and busy world, that includes careers and daily activities that require physical activity. While attempting to attain the required physical conditioning, people often take chances with their personal health as they try to stretch their physical limits. Sometimes, people can surpass their current limits and form new boundaries; however, other times people are not so fortunate. These unfortunate times often lead to injury, including workplace accidents, sporting incidents, disease afflictions, as well as others; any or all of which could bring about the need of rehabilitation services. Many of these require physical therapy, which includes assisting injured or otherwise impaired patients as they recover to their pre-injury status or to recover as much as is physically possible. The field of physical therapy is a choice career for those who enjoy helping people recover from injury, and the following text will provide reason for choosing this profession.
Stem Cell Basics. In Stem Cell Information [World Wide Web site] Bethesda, MD: National Institutes of Health, U.S. Department of Health and Human Services, 2009 [cited Friday, November 08, 2013] Available at stemcells.nih.gov
The sarcomere is found in structures called myofibrils which make up skeletal muscle fibres. Within the sarcomere there are various different proteins. One of the most significant, myosin is found in the thick filaments of the sarcomere. Although both cells contain myosin, it is important to highlight that smooth muscle cells contain a much lower percentage of myosin compared to skeletal muscle cells. Despite this, myosin filaments in smooth muscle cells bind to actin filaments in a manner similar to that in skeletal muscle cells; although there are some differences. For instance, myosin filaments in smooth muscle cells are saturated with myosin heads so that myosin can glide over bound actin filaments over longer distances, enabling smooth muscle cells to stretch further, whilst in skeleta...
The solution to this problem is located in the lab. Researchers across the country are working day in and day out to come up with a solution to accelerate the healing of soft tissues. They have come up with many solutions, from vibration therapy, to personalized rehab plans, but none of these are yielding truly significant results. I believe the solution lies at the molecular level. I believe that we can observe the healing of these soft connective tissues and learn from it. Then we can design a method from the observations to accelerate the production of the fibrils and collagen that will go on to make up the soft connective tissue. I have begun to take the beginning steps in solving this problem through my mentorship with Dr. Weinhold. Our research goals go hand in hand, which has led us to beginning research on the release of an angiogenic growth factor through a gelatin that will coat sutures. In theory, this angiogenic growth factor, once released from the crosslinking with the gelatin will stimulate the development of blood vessels around the recently repaired collagenous tissue. This, in turn, will allow the tendon/ligament to have a better oxygen supply and allow for quicker
Wiese-Bjornstal, D. M., Smith, A. M., & LaMott, E. E. (1995). A model of psychological response to athletic injury and rehabilitation. Athletic training: Sport health care perspectives, 17-30.
Wang PhD, James, and Jianying Zhang PhD. "Platelet-Rich Plasma Releasate Promotes Differentiation of Tendon Stem Cells Into Active Tenocytes." The American Journal of Sports Medicine 88.12 (2010): 2477-486. Print.
Creative new training methods, developed by coaches, athletes and sport scientists, are aimed to help improve the quality and quantity of athletic training ( Kellmann, 2010, p.1). However, these methods have encountered a consistent set of barriers including overtraining ( Kellmann, 2010, p.1). Due to these barriers, the need for physical and mental recovery in athletics brought an increasing attention in practice and in research ( Kellmann, 2010, p.1).
Athletic staleness and burnout is a big problem for many of today’s athletes whether they are at the amateur or professional level. The good thing about this problem that ends up in total and complete physical and emotional exhaustion is that it can be recognized when it is taking place. It can also be treated if the recognition comes at too late of a stage of the onset of staleness and burnout. But the best remedy for athletic staleness and burnout is prevention of it in the first place. There are three different models that have been used to explain the causes of athlete burnout.
Regenerative medicine also seeks to understand the ability of a tissue or organ to repair itself. Many adult tissue contain stem cells but are at times not functional or is impaired by disease. Using factors to activate and promote instrinsic repair in a diseased organ opens up whole new prospect for therapies targeted toward many degenerative diseases.[9]