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Cardiology boardnreview
Cardiology pathophysiology
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The Beat Goes On…
Make a fist. Is it possible that an organ that small is the possibility for life? The heart is made of pure muscle and although it would seem rather fragile, history has proven otherwise. It has shown its sturdiness and durability through the trial and error of the advancements in cardiology. Many things can go wrong with the heart however no matter how minuscule the problem may be, it can affect the entire heart, which in turn, would affect the entire body. The heart today is said to have evolved from the simple cells in the Porifera that pumps the water through the sponge (Zimmer), to a tube with an enlarged lump on it, to the multi-chambered pumping king we are now blessed with. Through the years it has been questioned how the heart has evolved and why, an eluding mystery we are still trying to solve. The mammalian heart is theorized to have developed to what it is today because of gene mutations. Although these gene mutations are usually beneficial, sometimes they can be detrimental and cause life threatening consequences.
Living from year to year, a specific gene sequence for an organism cannot be repeated with an exact clone millions of times. The sequence is often mutated and because of this evolution plays its role. In Carl Zimmer’s article The Hidden Unity of Hearts-the Evolution of the Human Heart, he writes about when the first heart related gene was found. In 1993, a scientist by the name of Rolf Bodmer found the single gene in fruit flies that when taken away, the heart was never developed (Zimmer). He named this gene tinman. Soon after this discovery, the Nkx gene was found and mice and had the same effect. These discoveries paved the way for scientists to find other genes that would affect the h...
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...ds a supply of its own blood to function properly. These arteries, called the coronary arteries, are responsible for this. The blockage of these arteries prevents oxygen from reach the heart tissue and leads to what is known as a heart attack.
The evolutionary development of the heart has come a long way from the singular tube to the multi-chambered complex ones that now operate in humans. Some scientists proclaim that the genetics over the years have not changed much at all. They also say that the human heart is a perfected machine that has seemed to reach the goal of its evolutionary time. However, the heart will continue to amaze us. With its constant abnormalities, gene mutations, and it’s striving for perfection, the heart will never be completely known and understood. Instead it will be an enigma, constantly dodging our rules and always providing us with life.
In this figure, SN = sinus node; AVN = AV node; RA = right atrium; LA
In the Tell-Tale Heart the story speak about a murder. The narrator telling the story
of the heart: one chamber is on the top and one chamber is on the
The development of the artificial heart began in the early 1950’s. The initial prototype, developed in 1970’s by the artificial developmental staff at the University of Utah, allowed 50 hours of sustained life in a sheep. Although this was called a success, the implantation of the artificial heart left the sheep in a weakened state. It wasn’t until late 1970’s and the early 1980’s where the improvement of the artificial heart actually received attention as a possible alternative to a heart transplant. The remodeled product of the early 1970’s did more than just the 50 hours of sustained life; it enabled the cow to live longer and to live a relatively normal life, with the exception of a machine attached to the animal.
The science and history of the heart can be traced back as far as the fourth century B.C. Greek philosopher, Aristotle, declared the heart to be the most vital organ in the body based on observations of chick embryos. In the second century A.D, similar ideas were later reestablished in a piece written by Galen called On the Usefulness of the Parts of the Body. Galen’s thesis was that the heart was the source of the body’s essential heat and most closely related to the soul. Galen made careful observations of the physical properties of the heart as well. He said “The heart is a hard flesh, not easily injured. In hardness, tension, in general strength, and resistance to injury, the fibers of the heart far surpasses all others, for no other instrument performs such continues, hard work as the heart”(Galen, Volume 1).
This condition is said to start within the sacromeric proteins, as past studies has called this disorder ‘the disease of the sacromere’ 6. The muscle around the left ventricle is so strong that is does not relax enough after contraction to regenerate blood back into the heart 5. Hypertrophic cardiomyopathy was discovered in approximately 50% of young individuals who died suddenly 5. A recent study observed the genes associated with hypertrophic cardiomyopathy. Within 20 sacromere and myofilament related genes, there were 1400 mutations noted in HCM 6. The mutations within the sacromere prevent normal shortening that causes the muscle to contract stronger, reducing relaxation. However, all the mutated genes are not proven to cause hypertrophy. The MYH7 gene seems to be the most frequent as 25-35% of patients with mild or severe HCM had this gene present 6. Despit...
Doctor Copeland and Jake Blount are as we have seen doomed to isolation because of
The cells of a cardiac muscle are shaped and wider and shorted than a skeletal muscle however they are stripped like skeletal
In “The Tell-Tale Heart” by Edgar Allan Poe, there are only five characters mentioned in the story: the narrator, the old man, and three police officers, none of whom is ever named. Throughout the story, the narrator tells the audience over and over that he is not mad. He becomes obsessed with trying to prove that he is not a madman and eventually goes crazy in the end. He tells the story of how he kills the old man after seven nights of watching him sleep. He has nothing against the old man and actually likes him, but it is the old man’s pale blue eye with a film over it that overwhelms the narrator with anger. This is when he decides to rid of this “vulture eye,” by murdering the old man. After finally finishing what he had set out to do, three policemen show up because of a complaint about a shriek. The narrator assures them that it was him that had shrieked because of a nightmare and asks the officers to sit with him. While talking with them, confident that they knew nothing, he starts to hear a noise increasingly get louder. He eventually cannot take it anymore and
The Tell-Tale Heart: An Analysis In Edgar Allan Poe’s short-story, “The Tell-Tale Heart,” the storyteller tries to convince the reader that he is not mad. At the very beginning of the story, he asks, "...why will you say I am mad? " When the storyteller tells his story, it's obvious why. He attempts to tell his story in a calm manner, but occasionally jumps into a frenzied rant.
Coronary heart disease is defined by the hardening of the epicardial coronary arteries. The buildup of plaque in the arteries slowly narrows the coronary artery lumen. In order to better understand the physiology of the disease, it is important to first know the basic anatomy of the human heart. The aorta, located in the superior region of the heart, branches off into two main coronary blood vessels, otherwise known as arteries. The arteries are located on the left and right side of the heart and span its surface. They subsequently branch off into smaller arteries which supply oxygen-rich blood to the entire heart (Texas Heart Institute, 2013). Therefore, the narrowing of these arteries due to plaque buildup significantly impairs blood flow throughout the heart.
In the “Tell-Tale Heart” by Edgar Allan Poe, the narrator is extremely uncanny due to the reader’s inability to trust him. Right from the beggining the reader can tell that the narrator is crazy although the narrator does proclaim that he is sane. Since a person cannot trust a crazy person, the narrator himself is unreliable and therefore uncanny. Also as the story progress the narrator falls deeper and deeper into lunacy making him more and more unreliable, until the end of the story where the narrator gives in to his insanity, and the reader loses all ability to believe him.
The heart is a pump with four chambers made of their own special muscle called cardiac muscle. Its interwoven muscle fibers enable the heart to contract or squeeze together automatically (Colombo 7). It’s about the same size of a fist and weighs some where around two hundred fifty to three hundred fifty grams (Marieb 432). The size of the heart depends on a person’s height and size. The heart wall is enclosed in three layers: superficial epicardium, middle epicardium, and deep epicardium. It is then enclosed in a double-walled sac called the Pericardium. The terms Systole and Diastole refer respectively and literally to the contraction and relaxation periods of heart activity (Marieb 432). While the doctor is taking a patient’s blood pressure, he listens for the contractions and relaxations of the heart. He also listens for them to make sure that they are going in a single rhythm, to make sure that there are no arrhythmias or complications. The heart muscle does not depend on the nervous system. If the nervous s...
The behavior of the narrator in The Tell-Tale heart demonstrate characteristic that are associated with people with obsessive-compulsive disorder and paranoid schizophrenia . When Poe wrote this story in 1843 obsessive-compulsive disorder and paranoia had not been discovered. However in modern times the characteristics demonstrated by the narrator leads people to believe that he has a mental illness. Poe’s narrator demonstrates classic signs throughout the story leading the reader to believe that this character is mad
Genetics & Personalized Medicine. (2013). University of Ottawa Heart Institute. Retrieved on February 3, 2014 from: http://www.ottawaheart.ca/research_discovery/genetics-personalized-medicine.htm