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The potential effects of teratogens during vulnerable periods of embryonic and fetal development
Factors Facting Prenatal Development
Factors Facting Prenatal Development
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Recommended: The potential effects of teratogens during vulnerable periods of embryonic and fetal development
The most critical times in development are when the fetus is in the womb of the mother. The fetus is at risk of harm from the things the mom consumes and is exposed to. Teratogens can especially do harm. They are defined as “an external agent that can cause damage or death during prenatal development.” (Siegler, DeLoache, Eisenberg, Saffran, & Leaper, 2014, p. 57) The consequences of a teratogen depends on when the unborn baby is exposed to it, how often they are in contact with the teratogen, and how susceptible one is to it. There are many known teratogens now, but determining one is difficult since you cannot expose them to fetuses because it would be unethical. For example, when thalidomide was given to women to help with morning sickness, people thought it was going to be safe because it was tested on lab animals and no effects were shown. It wasn't tested on any human fetuses, but since lab animals seemed to be fine it was assumed to be safe, however, babies were born with missing limbs. (Siegler, et al., 2014). Other known teratogens are certain prescribed drugs, pollutants, or a disease the mother has. They can all result in a birth defect and can affect the child’s future well being. Alcohol especially can have significant consequences when introduced during the …show more content…
For one of the tests the children were were shown images of animals on a computer for a certain amount of seconds and had to press a green key for “yes”, meaning the animal was previously shown, or a red button for “no”, it was not shown. Although there was no difference in information processing time between children of mothers who drank and those who did not, the number of correct answers shown from the choice reaction time shows there is a possible correlation with the mother’s alcohol consumption during pregnancy, but only with binge
The National Institution of Health published this article for the purpose of explaining about the human brain and it’s relation to alcohol. According to the article, people with alcoholism have been known to have problems with skills in their prefrontal cortex, the part of the brain that controls decision-making and emotions. These same people show exaggerated neural responses in the dorsal striatum due to alcohol-related cues. This information shows that excessive drinking can affect learning and control of behavior and emotion. This information can be helpful in my paper because it explains that alcohol is a disease that affects the brain and it will help me try to prove my point of view.
Slutske, W. S., D’Onofrio, B. M., Turkheimer, E., Emery, R. E., Harden, K. P., Heath, A. C., et al. (2008). Searching for an environmental effect of parental alcoholism on offspring alcohol use disorder: A genetically informed study of children of alcoholics. Journal of Abnormal Psychology, 117, 534-551.
There are many factors that are integrated into the successful development of a child from Prenatal growth into toddlerhood. Teratogens (outside factors) have a great impact on the babies’ inutero development. Some outside factors like second-hand smoke, smog, or fumes from cleaning chemicals can cause negative effects on the child inside the womb. A few major affects from teratogens could result in low birth weight, head circumference, slow physical growth as well as an effect on mental, behavioral and motor skills (Berk, 2003). The environment around the mother provides many of these outside factors affecting the baby’s growth. But the main link to teratogens during the gestation period is most likely the mother. Daniel S. Messinger and the National Institute on Drug Abuse found that 2.8% of pregnant women admitted to using illicit drugs during their pregnancy (1996). Through illicit drug use, tobacco use and alcohol use, the mother disrupts her baby’s growth with possibly permanent damage.
Tobacco use during pregnancy is another environmental influence. The nicotine, carbon monoxide, and many other harmful chemicals mixed together in cigarettes are very harmful to the mother and especially the unborn child. This can cut off the baby’s oxygen supply, increase the risk of
Childbirth is nothing short of a miracle. The placenta—the organ connecting a developing fetus to the uterine wall and allowing for waste elimination, nutrient uptake and gas exchange via the mother's blood supply—filters most harmful substances that threaten an embryo, though some may still pass on to the fetus. These harmful substances, called “teratogens,” range from environmental chemicals to the passing of maternal diseases, and can negatively impact the normal developmental cycle of a fetus. The title “teratogen,” however, effectually refers to any substance or chemical exposure with the potential to cause birth defects in prenatal development. Exposure to teratogens can result in a broad spectrum of physiological and psychological issues in later life, including malformations of the body. (Malformations resulting from exposure to one of the most common teratogens—alcohol—can be observed notoriously in Fetal Alcohol Syndrome, or FAS, where patterns of mental and physical defects develop in association with high levels of alcohol consumption during pregnancy.) Though the toxicity of these teratogens is particularly damaging during the fourth through tenth weeks of gestation, teratogens can harm throughout the span of development in the womb.
The data included 93 births before gestational week 22 which were included in a sensitivity analysis. In order to explore the potential impact of mothers who were nonresponsive regarding alcohol intake in pregnancy (n = 381), researchers compared data to the main analysis and found that the estimates regarding the impact of alcohol use on very early preterm birth were similar to previous results obtained regarding drinking prior to and during pregnancy. Thus, alcohol consumption in this study could not be linked to preterm birth (Dale et al., 2016).
Women who are pregnant, but drink moderate amounts of alcohol still pose many dangerous threats to their unborn child. A fetal alcohol effect is one of them, with slight deformities, mental retardation, and learning disabilities. Fetal alcohol effected children not only have physical differences from normal children, but also suffer with psychiatric problems and at more apt to get in trouble with the law. Pregnant women who drink not only run the risk of having a baby with fetal alcohol syndrome, but of having a child with alcohol-related neurodevelopmental disorder. Alcohol-related neurodevelopmental disorder occurs when children have prenatal exposure to alcohol. These babies have cognitive and behavioral problems that are alcohol-related, without the severe facial or growth deformities babies with fetal alcohol syndrome have. Pregnant women who drink expose their baby to teratogen ethanol- the active ingredient in alcohol. The fetus exposure is longer and more intense compared to the mother who is able to metabolize the teratogen ethanol.
Alcohol (wine, beer, or liquor) is the leading known preventable cause of developmental and physical birth defects in the United States. When a woman drinks alcohol during pregnancy, she risks giving birth to a child who will pay the price, in mental and physical deficiencies, for his or her entire life. One study (Phyllis Trujillo Lewis, MA, Philip A. May, PhD, and Virginia C. Shipman, PhD, 2007) asserted that “Numerous studies on alcohol-related birth defects have concluded that maternal drinking, compounded by other risk factors, leads to fetal alcohol syndrome (FAS). FAS is a serious birth defect and the most common non-genetic cause of mental retardation” as said by (Hankin, 2002; Abel & Sokol,1986; O’Connor, Kogan, & Findlay, 2002; May & Gossage, in press). It is unknown how much maternal alcohol consumption results in FAS or other related disorders, or why some women who drink are at substantially higher risk of giving birth to a child with alcohol-related disabilities than others (Stratton, Howe, & Battaglia, 1996). However, researchers have identified several maternal risk factors differentially associated with FAS. These include advanced maternal age, number of pregnancies, previous births of a child with FAS, cohabitation with a male partner who drinks heavily, and low socioeconomic status (SES; May et al. 2004; 2008a; Viljoen et al., 2002). FAS is 100% preventable, which makes awareness and education the core preventative method for FAS. It is seen through Lewis, May & Shipman’s research that women who are less educated are less aware of the risks involved with drinking while pregnant.
Forensic toxicology is one of the oldest disciplines in forensic science history and dates back hundreds of years. However, the actual understanding and examination of forensic toxicology only dates back for about 200 years. Due to the development of technology, this discipline has been able to progress and flourish.
In conclusion, the harmful effects of medications, alcohol and illicit drugs can be very dangerous to the health and development of a fetus during pregnancy. It is important to educate new mothers on the adverse effects that are associated with the use of these substances. With the right counselling and information provided, we can continue to keep newborns safe in the womb and be able to give them a chance at a healthy and painless future.
The affects teratogens can have on the developing fetus can vary greatly. Research provided from the University of Iowa’s on teratogens explains some of the possible outcome to exposure to certain teratogens. Listed birth defects resulting from exposure to teratogens, range from prenatal death, to physical and mental abnormalities.
In 2006, 49% of all pregnancies in the United States were reported unintended on a national survey.1 The highest rate of preventable birth defects and mental retardation is due to alcohol use.2 In this paper, I will further discuss FAS, the potential effects of binge drinking during the embryonic stage of gestation, and what actions need to be taken in order to reduce the incidences of alcohol-related birth defects. Alcohol Consumption During Pregnancy Alcohol is an ethanol containing substance that is a common beverage in many social and private settings. Alcohol is also a teratogen, therefore alcohol consumption and binge drinking potentially pose a substantial risk to the embryo or fetus. In 2013, the Centers for Disease Control conducted a telephone survey of women in the age range of 18-44 years regarding alcohol use.3
Dr. Mercola (2014) stated that in a survey of over 2,500 obstetricians 78 percent said they could reduce the risk of exposure to environmental toxins by consoling their patients. Dr. Mercola (2014) also noted that 50 percent of these doctors rarely take an environmental health history and less than 20 percent said they routinely ask about environmental exposures common to pregnant women. These numbers indicate to me that the doctors also have to take more of a responsivity of asking and preparing women for dealing with these toxins and risks it can have on the baby. We have to come together as citizens and doctors to do our best to limit birth defects especially birth defects by way of exposure to these toxins. This seems to be an issue a lot of doctors and patients don’t put a ton of spotlight on. Dr. Mercola (2014) also noted that the lead author of this research Naomi Stotland said “Providers were saying, if I bring this up with patients… it’s going to raise anxiety and questions that I don’t know how to deal with… There’s a sense that, yes, these things may be harmful, but I don’t how to tell her how to reduce the risk. “Reading this quote I was a bit in awe that for all the schooling that doctors go through they don’t how to deal with this important subject. More research needs to go into this so doctors can be more educated on how to deal with this so they
The first trimester of pregnancy is the most sensitive trimester for a developing fetus. There are a few different ways that mothers and fetuses can be exposed during this sensitive time. They can be exposed accidentally, knowledgably, or with no knowledge of the pregnancy. An example of an accidental exposure is a radiation accident, like Chernobyl. There was no way to record the actual dosage of radiation that each child received in utero, or the amount of women who had spontaneous abortions after being exposed to the accidental radiation. It has been shown that those babies “exposed during the most sensitive period of pregnancy performed less well [on verbal IQ tests] than those who were exposed after week 16 of pregnancy” (Heiervang 213). There appear to be more significant birth defects and abnormalities in fetuses who were exposed prior to the 16 week gestational mark.
Every woman when pregnant has a 3-5% chance of having a baby born with a birth defect, and these chances increase when the developing fetus/ embryos are exposed to teratogens, whether it’s intentional or unintentional (Bethesda (MD), 2006). Teratogens can cause severe birth defects, malformations, or terminate the pregnancy altogether (Jancárková, & Gregor, 2000). The placenta is known as an effective barrier from any detrimental pathogen that can potentially hurt the fetus. The timing of exposure of any teratogen is critical to the impact of prenatal development (Bethesda (MD), 2006). The most vulnerable time of the fetus for severe damage is during early pregnancy when all the major organ and central nervous system (CNS) are developing. Miscarriages have an important role in keeping a pregnancy from evolving when there is something serious going on with the developing fetus/embryo. Miscarriages are more common than we think and are the most familiar type of pregnancy loss (Bethesda (MD), 2006).