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What is a pandemic? essay
Importance of vaccinations today
Importance of vaccinations today
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Pandemics and epidemics are diseases that affect many people all over the world. They cause millions of deaths and leave many people sick. Most epidemics are contagious and spread very quickly. One kind of epidemic is the variola virus. Variola virus is most known by the name smallpox. it got it’s nickname from the small blisters that appear on the face and arms. Smallpox is believed to have originated in Egypt or Northeastern Africa about 10,000 years ago. It soon reached Asia during the middle ages and reached Europe in 700 A.D.In 18th Century Europe it killed about 400,000 people a year. In the 20th Century alone, it has killed about 300 million. This disease has also led to the downfall of the Aztec Empire and killed many royal figures from France, Russia and other countries.
Most people do not know but, there are four types of the smallpox virus, variola major,variola minor, hemorrhagic smallpox and malignant smallpox. Variola major kills 30% of those infected with the disease while variola minor only kills 1% of those who are infected. Hemorrhagic smallpox causes the organs...
In closing, the variola virus affected a great amount in that era including, military strategy, trade, and native populations. Elizabeth A. Fenn’s book Pox Americana: The Great Smallpox Epidemic of 1775-82 sheds light on a significant aspect of that era that had not been given proper credence beforehand. She also illuminated the effect of smallpox when it came to race and social status. With regard to race, smallpox decimated much of the non European populations partly because of their lack of an innate immunity to that virus and Europeans lack of regard for those of a different race. Fenn’s argument on social status showed how the poorer strata’s of society suffered more severely from the variola virus because of their lack of finances to get inoculated; thus, the poor often suffered a worse strain of the virus which often lead to death.
Orthopoxvirus variola is the virus responsible for the well-known smallpox disease. It belongs to the Poxviridae family which is further split into the subfamilies Entomopoxivirinae which only affects insects, and Chordopoxivirinae which infects vertebrae (Hughes). It is in group one of the Baltimore Classification since it possesses double-stranded DNA. This group also includes viruses in the Herpesviridae family, certain bacteriophages, as well as the mimivirus. The linear genome consists of approximately 186 kb pair and, like all orthopoxviruses, is about 200 nm in diameter (Li; Riedel). Virus particles may be enveloped, but the majority will be nonenveloped when released from a lysed cell, ready and capable to affect another. Extracellular enveloped viruses evolve from their precursors intracellular enveloped virus and cell-associated enveloped virus and contain proteins that aid the virus in neutralizing host cell antibodies to enhance virus spread (Smith). Entrance into the host cell may be accomplished by fusion of endocytosis, contingent on the particular strain. Host cell cytoplasm is the site of poxvirus replication, therefore host nuclear enzymes are unavailable to the virus; to overcome this, DNA-dependent RNA polymerase enters the host with the virus (Hughes).
The perspective the author gives to this book is a unique. Smallpox according to most histories does not play the role of a major character, but a minor part. In my opinion smallpox was a major factor during the Revolutionary War, and Feen focuses on several key areas which allows us to see just how bad this epidemic was and the grip it had not only on the soldiers, but the colonist as well.
1. The contrast between Cottard and the other characters is that while everyone else is in constant fear of catching the plague and doing everything they can to fight the disease, Cottard is cheerful in the fact that the plague has put a stop to the police investigating his mysterious crime . Cottard probably also enjoys the camaraderie of everyone else finally being in the same position as he is.
Native Americans were completely susceptible to contracting the disease, but they weren't the only victims. Twenty people died on the Mayflower as a result of smallpox. There was a smallpox outbreak in Plymouth Colony around 1633. Twenty people died including their only physician. This was the beginning of the colonial's struggle with the disease.
In order to understand the history of smallpox one first has to understand how diseases like it evolve. Much like other species, diseases that survive in the long run are the microbes that most effectively reproduce and are able to find suitable places to live. For a microbe to effectively reproduce, it must "be defined mathematically as the number of new infected per each original patient." This number will largely depend on how long each victim is able to spread the virus to other victims (Diamond, 198).
Pandemics, once started, are expected to spread worldwide. They cannot be stopped from spreading, once they outbreak, they continuously spread. The Black Death was a disease that spread throughout the Mediterranean and Europe. There were approximately 25 million deaths in Europe alone. The Black Death was caused by the bacterium called Yersinia Pestis during the 13th century. The Black Death, also known as the Bubonic Plague was caused by a single contamination of one person. The Black Death was caused by a single bacterium, overcrowding in areas like Europe, which effected a huge part of the population by simply killing it off.
From 166 A.D. to 180 A.D., The Antonine Plague spread around Europe devastating many countries. This epidemic killed thousands per day and is also known as the modern-day name Smallpox. It is known as one of deadliest plagues around the world.
It was spread very slowly and less broadly than other viral illnesses which took a long time to identify the infection in the first two weeks. Infection of smallpox started to grow between 7 to 10 days when the scabs formed into bruises. The signs and symptoms of this disease include high fever, widespread rashes, redness, muscle pain, headache, common cold, vomiting, nausea and many more. Consequently, the virus was found in the bone marrow along with bloodstream in huge numbers. There are different types of the smallpox disease with other classifications.
Although the Columbian Exchange allowed for the beneficial exchange of cultures, ideas, foods, and animals around the world during the 1450-1750 time period, it also had a dark side. One detrimental result of the Columbian Exchange would be the spreading of smallpox from Europe to the New World.
A pandemic is an outbreak of an infectious disease that spreads through human populations across a large region, whether that be multiple continents or worldwide. In order to be considered a pandemic, a disease must cross international boundaries and be contagious or infectious. Pandemics are usually caused by a new virus strain that humans have either very little or no immunity against. This contagious virus spreads easily from person to person, through direct contact or coughing and sneezing. A serious illness is caused worldwide from the virus, wiping out entire populations. Some of the deadliest pandemics include the Black Death, the Spanish influenza, and the second cholera pandemic.
For approximately three-thousand years, smallpox has ravaged and plagued the four corners of the globe. In fact, in the 17th and 18th centuries, it was claimed to be the most infectious disease in the West, with an astounding 90% mortality rate in America. It wasn't until 1796, with English surgeon Edward Jenner's smallpox vaccination, that the world saw relief from this devastating virus. However, even with this inoculation in use, the world continued to witness death from both the virus and the vaccine. In the year 1966, it was estimated that 10-15 million infected citizens worldwide had passed away from smallpox that year alone ( “History” 12).
Throughout history many different diseases have infected the world. Such diseases consist of measles, mumps, malaria, typhus and yellow fever. Many of these diseases are caused by different things and originated in different countries.
Malaria (also called biduoterian fever, blackwater fever, falciparum malaria, plasmodium, Quartan malaria, and tertian malaria) is one of the most infectious and most common diseases in the world. This serious, sometimes-fatal disease is caused by a parasite that is carried by a certain species of mosquito called the Anopheles. It claims more lives every year than any other transmissible disease except tuberculosis. Every year, five hundred million adults and children (around nine percent of the world’s population) contract the disease and of these, one hundred million people die. Children are more susceptible to the disease than adults, and in Africa, where ninety percent of the world’s cases occur and where eighty percent of the cases are treated at home, one in twenty children die of the disease before they reach the age of five. Pregnant women are also more vulnerable to disease and in certain parts of Africa, they are four times as likely to contract the disease and only half as likely to survive it.
When looking back on history, it is evident to see that humans by nature are warriors. Humans often find themselves fighting mysterious battles against disguised enemies. Throughout history the earth has been afflicted with mysterious diseases, which tend to invisibly cause the preponderance of civilizations to perish. The evolution of infectious diseases has and always will provide challenges for humankind (Hoff, Smith, and Calisher 6-7). Over the course of time, humans gradually developed a preference to live in large urban settings. Urbanization and the cross-cultural interaction of civilizations have both strongly provoked widespread illness, which is known as an epidemic or pandemic based upon size. An epidemic is when a common disease affects a large number of people within a particular region (Lamb). A pandemic is similar to an epidemic but is even more widespread than an epidemic, and spreads throughout entire continents or even the world. Despite the slight variation in meaning, most pandemics are interchangeably denoted as epidemics (Friendlander 13-14). Epidemics and pandemics have formed the course of human history by inflicting lifestyle alterations and abruptly killing large masses of people. When one thinks of widespread disease it is easy to think that pandemics and epidemics are things of the past. Unfortunately, epidemics are commonly found today in poorer countries and major pandemics are still on the rise, such as the modern disease AIDS (Lampton 12-15). Nonetheless, epidemics and pandemics affect large portions of the world’s population; thus, these ongoing diseases will always influence the history of mankind because they force transformation amongst even the strongest civilizations.