Phencyclidine: The Dawn of a New Age
April, 1956 : The pharmaceutical company Parke & Davis first synthesize what they believe to be the perfect anesthetic (Souza, 1995). When administered to patients, it causes a completely dissociative state, with no significant respiratory or cardiovascular depression. Patients appear to be awake, eyes open, breathing normally.but are unaware of their surroundings or the procedures being performed upon them (Souza, 1995). Indeed, this is the perfect drug.
Unfortunately, like all good things, this one has a darker side. 15% of patients awake from their slumber with what appeared to be an acute case of paranoid schizophrenia (Peterson; Stillman, 1978). The drug is PCP, and to this day it is the scourge of the underground drug community, and the focal point of intense scientific research. Parke Davis and Company did not know how terrible, and wonderful, a discovery they made that day; but our world has been changed forever because of it.quite possibly for the better.
The Dust of Angels
Phencyclidine, more commonly known as PCP, is a polycyclic compound belonging to the arylcyclohexylamine class of chemicals [figure 1.0] (Souza 1993). In pure form, it is a white powder which readily dissolves in water. The cyclohexamines are known for their the potent neurological effects, with PCP being the most potent. Almost every variation has been administered to, or abused by, humans at some time (Nintey Fifth Congress, 1978). All these compounds have similar pharmacological effects, which vary considerably according to the amount administered. Small doses produce a `drunken' state, in which subjects report a numbness in the extremities, while some species (like dogs and cats) become quite excited (Halberstadt, 1995). Intermediate doses have anesthetic and analgesic effects , with the psychic state resembling sensory isolation with one important exception: the sensory impulses (when tested electrophysiologically) reach the neocortex but "the neuronal signals are grossly distorted"
(Halberstadt, 1995). Large doses, especially of PCP, may produce convulsions.
Any dose produces cataleptoid muscle effects (Halberstadt, 1995). All the chemicals in this class produce a range a physiological effects, including tachydardia and hypertension (Halberstadt, 1995). Unlike the other cyclohexamines, however, PCP causes severe "e...
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...phy - dont forget this!
Carroll, Marilyn. (1992). Encyclopedia of Psychoactive Drugs. New York, N.Y:
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Halberstadt, A.L. (1995). The phencyclidine-glutamate model of schizophrenia.
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Nintey Fifth Congress. (1978). Abuse of dangerous and illicit drugs - psychotropics, phencyclidine (PCP), and talwin; Hearings before the select committee on narcotics abuse and control house of representatives. Washington,
DC: US Government Printing Office.
Okuyama, Shigeru. (1994). NE-100, a novel sigma receptor ligand: Effect on phencyclidine-induced behaviors in rats, dogs, and monkeys. Life Sciences. (Vol.
55) PL133-138
Peterson, R.C, & Stillman, R.C. (1978). PCP-Phencylidine Abuse: An appraisal.
New York, NY: National Institute on Drug Abuse.
Restak, R.M. (1994). Receptors. New York, N.Y: Bantam Books.
Souza, Errol B., & Clouet, D., & London, E.D. (1993). Sigma, PCP, and NMDA
Receptors. New York, NY: National Institute on Drug Abuse.
Svensson, T.H. (1995). Mode of action of atypical neuroleptics in relation to the phencyclidine model of schizophrenia. Journal of Clinical Psychopharmacology.
(Vol. 15) 11S-18S
Over the past 60 years there has been a recent phenomenon in the development and rise of gangs and gang violence. This is exceptionally apparent in South Central Los Angeles, where the Bloods and the Crips have taken control of the social structure and created a new type of counter culture. Poverty in this area is an enormous problem caused by a sheer lack of jobs; but just because there is a lack of jobs doesn’t mean that there will be a lack of bills to pay, so sometimes selling drugs in order to keep a roof over your head seems like the most logical option. Crime often times flourishes in these regions because the inconvenient truth is; crime pays. Senator Tom Hayden stated “It’s been defined as a crime problem and a gang problem
In the 1970’s Patricia Adler and her husband infiltrated a large drug smuggling and dealing ring located in Southwest County of southern California with the intent of learning more about the covert group. In Adler’s book Wheeling and Dealing: an Ethnography of an Upper-Level Drug Dealing and Smuggling Community, she delves into the multifaceted lifestyle and activities of those in the Southwest County drug world. In this paper, I will look into the factors that initiated their entry into the drug world, their activates that facilitated their smuggling and dealing of drugs, and their exit from the drug world, while applying multiple theories to explain their illegal behavior.
Philadelphia is the heights rat of crim in the USA over 30-40 homicides crimes per month and drug related crimes. This links in with the other text that we are looking at, the novel “Damage done” and how is shows that sometimes facts get in the way of a good story. This all promotes the current view Australia has one drugs, the way that there is supposably an ice epidemic happing. This document follows Theroux around Philadelphia’s drug action streets while he does interviews with the criminals and follows the police around finding out what is really happing out on the streets of Philadelphia. Some events that where selected to promote this view to the audiences was the interview with the street boys, showing just how carpeted Philadelphia is how they talk of “code of silence – never snitch!”. There was all so the confronting images of the dead body left in the abandoned house, from a suspected over does on ice. The drug issue in Philadelphia is represented in way that it controls the streets nothing ever happens unless its drug related. These parts have been purposely highlighted throughout the documentary to get the most dramatic message across to the views, as dose the novel. Tis representation achieves the goal of getting the message across of how street gangs and drugs are becoming to rules the streets. This message impacts and effects the way the audients sees this type of action and making them believe that it is taking place all around them. This documentary is to inform and promote the understanding of these types of actions, this is all so done with some help of filming
Due to the serious consequences of the drug problem and its related crimes in the United States, law enforcement identified six goals to handle cases of such nature. The first goal is to reduce the gang violence associated with drug trafficking and prevent the emergence of powerful organized criminal groups. Organized group are the main distribution of drugs in the community. They sell drugs for many reasons. It’s fast money, help fund other criminal activities and difficult for law enforcement to build a case against them for it. The drugs problem brings other crimes into the community. With drugs comes violence, drug wars and death. It is the main cause of the degradation of the community. Therefore, confronting the root of the problem by
In the 1980’s crack cocaine hit the streets of Los Angeles for some it brought quick fortune but for many doom. Crack cocaine had become a major source of income for those who had been locked out of mainstream America. Heavily armed the Rolling 60’s were one of the most violent, active gangs in Los Angeles. The Rolling 60’s gang members no longer fought over neighborhood rule but, profit endeavors. Gang members had became both a slave to the business, doing whatever the drugs demanded them to do. Crack cocaine had erased those codes of res...
Credibility material: Its intake results in adverse medical conditions that are further exalted by its addiction properties that ensure a continued intake of the substance. The drug can be abused through multiple means and is medically recorded to produce short-term joy, energy , and other effects such as increased heart rate and blood pressure. This ultimately results in numerous psychiatric and social problems; factors that played a major role in its illegalization after multiple and widespread cases of its effects were reported in the country during the 1900s. In addition to this, the drug results in immediate euphoric effect, a property which the National Institute of Drug Abuse (2010) attributes to be the root cause for its increased po...
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Drug trafficking is a prohibited, global trade that involves the production, the distribution, and the sales of drugs. It is a topic that has become a very large issue all over the world. It also has had a very big effect on many different countries because they often depend on the business that the drug trafficking creates. Since it has become such a problem, there have been many different efforts to put a stop to drug trafficking by different enforcement agencies. A website about drug statistics, drugabuse.net, indicated that the Drug Enforcement Agency or DEA, as it is well known as, makes over thirty thousand arrests each year dealing with the illegal sales or distribution of drugs. It is also believed that Mexico’s economy would shrink by over sixty-three percent if they lost their drug trafficking industry. There are many different tribulations like this that drug trafficking has created. Many people see it as such a vital asset to some countries, so it has emerged as an extremely big business that brings in a boatload of money. Just like any other immense problem, drug trafficking has its causes and effects
Crack is the name given to cocaine that has been transformed into a condensed, more pure, rock form that can be smoked. It is the most addictive form of cocaine due to a higher potency level than the typical batch of street cocaine. Crack cocaine has often been referred to as a ‘soul drug’ because it has a tendency to rob its victims of everything including money, family, morals, and even life itself. Furthermore, it is possible to become addicted to crack cocaine from the very first time it is used, creating a vortex of misery for those who come into contact with it. Compared to other drugs, crack cocaine has a rather short history in America since it was only introduced the 1980’s. However, within this short period, Crack cocaine
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In the 1970s, cocaine was expensive and considered a "status" drug. The introduction of inexpensive crack increased the accessibility of this substance, and crack has become the drug of choice for many users, especially for inner...
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