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Cocaine and the nervous system
Cocaine and its effect in the drug war
Neurobiology of cocaine on the brain
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Crack Cocaine
Crack is the name given to cocaine that has been transformed into a condensed, more pure, rock form that can be smoked. It is the most addictive form of cocaine due to a higher potency level than the typical batch of street cocaine. Crack cocaine has often been referred to as a ‘soul drug’ because it has a tendency to rob its victims of everything including money, family, morals, and even life itself. Furthermore, it is possible to become addicted to crack cocaine from the very first time it is used, creating a vortex of misery for those who come into contact with it. Compared to other drugs, crack cocaine has a rather short history in America since it was only introduced the 1980’s. However, within this short period, Crack cocaine
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has managed to wreak havoc in the American population, claiming the lives of thousands and leaving its mark on America’s war on drugs. Fortunantly, there is now a public awareness concerning the detriments caused by crack cocaine and its users. By understanding the drug itself, the physical and psychological power that it holds on its victims, and the detrimental effects that it causes both emotionally, physically, and socially, opens a door to treatment and rehabilitation among its users, in a hopes that they are able to reclaim their life. As mentioned previously, crack cocaine is the most potent form of the drug cocaine.
Cocaine itself is derived from the coca plant commonly found in South America. For centuries, the native people of South America have used the coca plant, its leaves in particular, as a stimulant for long work hours as well as for medical purposes. It was not until 1859 that modern cocaine was developed as a drug in Germany (Crack Cocaine History, n.d.). By the late 1800’s, the medical knowledge of cocaine had spread world-wide and many American doctors began to prescribe the use of cocaine as a medical drug to cure different illnesses and ease common pain. It wasn’t until the early 1900’s, however, that the negative side effects of cocaine became apparent; these side effects included addiction and death. With such detrimental side effects, cocaine was declared a threat to the nation and in 1914, cocaine became what’s known as a controlled substance that could only be obtained by a prescription from a doctor for medical reasons only (much like today’s ‘medical marijuana’). However, by controlling access and usage of cocaine, America inadvertently gave way to an entirely new drug cartel that they weren’t prepared to deal with. In the beginning of cocaine being a controlled substance, it became less popular and one of the lesser drugs to be abused in the United States. It wasn’t until the 1960’s and 70’s that the use of cocaine became popular again. This widespread ‘cocaine boom’ affected all …show more content…
social and economic classes throughout America. During this time, and even still today, the most common form of assimilation was through snorting the cocaine in its powdered form. However, some users did in fact inject the cocaine into their blood stream and only some could afford to smoke the cocaine available because it smoking the drug required a larger quantity of the substance. (Crack Cocaine History, n.d.) As a result of the continuous rise of cocaine usage, both shipping and dealing of the drug increased in the United States. However, “By the early 1980’s, the cocaine market became glutted with an excess of the drug, causing cocaine prices to drop sharply” (Crack Cocaine History, n.d.). Due to the influx in product and decrease in profit, cocaine dealers came up with a way to increase their profit once again by converting the powder into a smaller more potent form, giving birth to the notorious crack cocaine. The production of crack cocaine was simple and inexpensive, therefore, the profit margin was exceptional. Unlike typical cocaine, crack could be smoked by the user rather than snorted which produced an even more extreme high in a quicker manner. Crack cocaine was cheap, quick, and intense, making it extremely popular. Furthermore, crack cocaine did not discriminate; it affected people from all social and economic classes. With such popularity, it didn’t take long for crack to pervade most major cities throughout the nation, leading to a major drug epidemic and a nationwide crisis. Combining the fact that crack quickly became one of the most lucrative drugs in terms of dealing and that the drug was highly addictive to those who used it, the crime rate exploded in the United States. “Gangs fought over drug dealing territory, killing innocent victims who were caught in the crossfire, and crack cocaine addicts turned to criminal activity to support their habit” (Crack Cocaine History, n.d.). This high rise of crime resulted in a significant rise in jail sentences within the American population fueling the crisis even further. Unfortunately, crack cocaine had already gripped a large portion of society creating a proliferating demand for the drug, in which violence and illegalities continued to grow with the production and distribution of crack (Crack Cocaine History, n.d.). Most cocaine that is delivered to the United States is in the form of hydrochloride powder derived from the coca plant. The extraction of the cocaine from the coca leafs is an extremely laborious task that involves mixing the leaves with a solvent (such as gasoline) and then drying it. Several chemicals and processes take place to produce and synthesize the solid form of cocaine hydrochloride that is delivered to the states. In the hydrochloride form of cocaine, the drug can only be snorted, ingested, or dissolved for injection; the powder is unable to be smoked due to the fact that the drug evaporates as such a high temperature that the cocaine simply burns away. However, through different chemical manipulations and processes, cocaine can be turned into a smokeable form known as ‘freebase’. Essentialy, freebase is a product of cocaine that through chemical reactions with a liquid base (such as ammonia, baking soda, etc.) removes the hydrochloric acid from the substance thus creating a solid, more pure, form of what originally was cocaine (Crack Cocaine History, n.d.). The production and synthises of crack cocaine greatly resembles the chemical synthesis of freebase. During the cocaine boom, dealers of the drug searched for a quicker, cheaper way to crystalize the drug. It didn’t take long for them to figure it out. “Cocaine hydrochloride is dissolved in water, sodium bicarbonate (baking soda) is added, and the mixture is heated and then dried into hard, smokeable pellets. These pellets contain not only alkaloidal cocaine, but sodium bicarbonate and whatever other fillers and adulterants had been added earlier to the powder; thus, crack is not as highly purified as freebase, and street samples tend to range from 10 to 40 percent cocaine by weight (Crack Cocaine History, n.d.). When the crack is smoked, the vapor consists mostly of pure cocaine and is very similar to smoking freebase. However, crack cocaine is a much more simple process and is usually completed by the drug dealer. The dealers ‘cook up’ the crack and sell the crystalized form as crack, beginning the production and sales of the soul drug. Furthermore, the melting point of crack is substantially lower than that of Cocaine hydrochloride which is why crack is smokeable and cocaine is not (Agency, 2004). “Crack cocaine is a strong central nervous stimulant that interferes with, and causes excess amounts of dopamine in the brain. A neurotransmitter associated with pleasure and movement, dopamine is the neurotransmitter released as part of the brain’s reward system” (Research, n.d.). This sudden increase in pleasure and ‘good-feeling’ provides the user with a feeling of euphoria which is what makes the drug highly addictive. However, the euphoric feeling that crack provides is only temporary, lasting only a few minutes. Because of this, crack users begin to crave the drug so that they can go back to the euphoric state that they were in. As one researcher put it, “the psychological effects can be extremely reinforcing: after having tried crack cocaine, the user will rapidly develop an intense craving for the drug since the chemistry of the brain’s reward system ahs been altered (Research, n.d.). This is why crack users, or avid drug users in general, are labeled as ‘feigns’; their brain is sending uncontrollable craving signals to the rest of their body. Furthermore, when a drug is smoked rather than snorted it is able to reach the brain more rapidly which gives the user a quicker and more intense high making it even more addictive. As with any drug, the more someone uses it, the more of a tolerance the body builds against the drug (as a defense mechanism), thus making it more and more difficult to experience the initial high that the drug produced. Unfortunantly, despite the build up tolerance, most crack users continue to smoke crack at alarming rates in hopes of achieving that euphoric high (Research, n.d.) Crack cocaine produces a psychoactive effect by interacting with the central nervous system, stimulating it to perform its ordinary functions more intensely.
This system operates through the release of various neurochemical transmitters (from the nerve cells in which they are produced) and their binding to receptor sites on neighboring cells. The constant release and binding of these neurotransmitters forms a pathway of “messages” that travel throughout the body, sustaining life and making possible the organism’s response to environmental stimuli. The drug also has an impact in the autonomic (or involuntary) division of the central nervous system, which helps regulate a variety of bodily functions that are generally free of volitional impact, including respiration, circulation, digestion, and body temperature. Ordinarily, these functions are maintained at relatively stable levels throughout the day. But they are slowed down during periods of rest through diminished production, release, and binding of neurotransmitters and can be speeded up, as needed, through increased neurotransmitter activity. It operates in the system by increasing the concentration and binding activity of the body’s own neurotransmitters, particularly dopamine. Thus, what people experience as the stimulant effect is an intensification of the body’s normal stimulatory mechanisms. (Pharmacodynamics: Cocaines Interaction with the Human Organism,
n.d.)
“Just Say No!” A statement that takes us deep into yet another decade in the history of the United States which was excited by controversies, social issues, and drug abuse. The topic of this statement is fueled by the growing abuse of cocaine in the mid 1980s. I shall discuss the effects of the crack cocaine epidemic of the mid 1980s from a cultural and social stand point because on that decade this country moved to the rhythms and the pace of this uncanny drug. Cocaine took its told on American society by in the 1980s; it ravaged with every social group, race, class, etc. It reigned over the United States without any prejudices. Crack cocaine was the way into urban society, because of its affordability in contrast to the powdered form. In society the minorities were the ones most affected by the growing excess of crime and drug abuse, especially African Americans; so the question was “Why was nearly everybody convicted in California federal court of crack cocaine trafficking black?” (Webb: Day 3). The growing hysteria brought forth many questions which might seem to have concrete answers, but the fact of the matter is they are all but conspiracy in the end, even though it does not take away the ambiguity and doubt. I will take on only a few topics from the vast array of events and effects this period in time had tended to. Where and who this epidemic seemed to affect more notably, and perhaps how the drugs came about such territories and people. What actions this countries authority took to restore moral sanity, and how it affected people gender wise.
Cocaine is a classified ‘Schedule II’ drug, also known as “crack”, and “coke” it is a powerful drug, and addictive stimulant well known as a psychoactive substance. That comes from a plant called coca leaf that has been around since the mid-1800s and throughout the 20th century. “In the mid-1980s, addiction to the drug was seen as exaggerated or dismissed as psychological and not addiction” (Miller, Gold, Smith, 1997, p.62). In the past, cocaine’s original use was for medical purposes as local anesthetic for surgeries. Now its usage is illegal and this drug is immersed into the body through various ways. However,...
Clayton, R. R. (1996). Cocaine use in the United States: In a blizzard or just being snowed. Cocaine Use in America: Epidemiologic and Clinical Perspectives. National Institute on Drug Abuse Research Monograph, 61, 8-34.
Gootenberg, Paul. Andean Cocaine: The Making of a Global Drug. Chapel Hill, NC: The University of North Carolina Press, 2008.
...native Indians. The native people have used the coca leafs as a medicinal drug up until the present day. Until the early 1950’s the coca leaf was readily used in soft drinks and was considered socially excitable in the United States. In the early 1960’s the United States made cocaine illegal and created a large underworld in most Latin America countries. By the mid 1960’s over sixty five percent of Bolivia’s workers made their livelihood off the coca plant. The Bolivian government had no reason to try to stop the drug trade in their country; cartel leaders were paying huge payments to government officials. During the 1980’s Ronald Regan attempted to curve the in flux of cocaine in to the United States with no real results. During 1990’s the United States started to send large amounts of funding and training for Latin America’s military to combat the cartels.
United States Sentencing Commission. (2009). Report on Cocaine and Federal Sentencing Policy. Retrieved from http://www.ussc.gov/: http://www.ussc.gov/
Columbia became the main place where cocaine is grown and distributed. The rise of cocaine in the 1980’s lead to the rise of many criminals including The Cali Cartel and The Medellin Cartel which included Pablo Escobar. Cocaine is a highly addictive drug and a nervous system stimulant. The drug has many side effects and can lead to death when overdosed. Cocaine is a weak alkaline base which means it can easily be made into various salt forms. It is the purest form as a white pearly substance. It is metabolized in the liver and when mixed with alcohol cocaethylene. Cocaine can be taken orally, sniffing, injection, inhalation and suppository. Between 2000 and 2006 deaths from cocaine abuse approximately doubled, rising to over 6,000 deaths per year. Cocaine was historically used as a topical anesthetic in eye and nasal surgery but, has been replaced in western medical practices.
Cocaine can be traced back thousands of years, but its presence wasn’t widely known in North America until the late 1800’s and once it hit, there was an epidemic (Gootenberg 191-192). Cocaine was found to be highly addictive, forming a strong physiological and psychological dependence due to its direct effect on the brain’s central nervous system, specifically the reward pathway.
...a prolonged period of time. This sensation is followed by increase heart rate, blood pressure, and sexual appetite. Dopamine uptake continues to be blocked by constant use of cocaine as the system releases less and less dopamine and the reward system goes dry. The cocaine user becomes anxious and unable to experience pleasure without the drug. Consequently, the postsynaptic cells become hypersensitive and sprout new receptors in a desperate effort to pick up dopamine signals. A vicious cycle of addiction begins and cocaine is needed to experience pleasure as it suppresses dopamine release even more. Dopamine alone is not enough to maintain addiction, glutamate, which plays an important role in learning, is required to maintain addiction. Glutamate signaling seems to cause more permanent changes in the brain that leads to the drug-seeking behaviors elicited by users.
The use of cocaine in the United States has declined over the last twenty years while the use of crack has increased. Many people avoided the use of crack because of the harmful chemicals used in creating the drug. One of the reasons why crack became popular is because of not needing to inject the drug hence less risks of being infected by the AIDS virus. Carroll (2000) states cocaine is the most powerful stimulant of natural origin. Most users snort or inject the drug to enable a quicker “high.” Cocaine use brings on many health problems. Fatal complications occur from regular use, for example, liver damage, seizures, elevated blood pressure causing stroke, heart failure, or heart attack.
Crack is made from powered cocaine and is sold in rock form. The crack rocks are crystallized in the cooking process and are yellow and tasteless. The drug produces an intense and almost immediate high. Smoking crack allows doses of cocaine to reach the brain within seconds and effects begin within minutes. Leading us to experience a combination of abnormal strength feeling, poor impulse control and delusions.
In 2006, 8.6 million Americans over the age of 12 have admitted to having tried some form of crack cocaine (“Crack Cocaine Usage Statistics”). Considering the notorious effects of cocaine, that 's a very unsettling statistic. Whether snorted, smoked or injected, cocaine is an addictive and dangerous drug that is known for its prominence during the 1980s. It is common knowledge that crack has devastating effects on an individual 's body, but that may not be relevant to somebody who believes crack will not affect them if they abstain from usage.On the contrary, if crack starts to affect a large group of individuals, it can have negative societal and health effects that can negatively impact the communities in which it inhabits.
Cocaine is an addictive drug made of coca leaves, which are sacred leaves in Bolivia, as the leaves are believed to have healing powers. As I learned from https://www.yachana.org/teaching/ students/webpages/andean2k/cocaine/history.html, coca leaves have been used for a long time as a food substitute (because it satisfies your craving for food), simulant (it’s an antidepressant), medicine (weak to strong), to keep warm, and “as a measure of distance” (it allows you to work for long amounts of time with no pain). When Diego smoked the cocaine he was no longer hungry, he was very happy and he worked for hours in the pit with no pain. But I don’t think cocaine is important to the story because Diego smoked it, although to me it did symbolize the
I’ve learned that people who begin using, Cocaine will most likely become a heavy drug user. Cocaine is also known for being a very harmful drug, it can cause multiple symptoms. You can get Cocaine in 2 different forms, cocaine powder and crack. These are both different forms. It can be snorted, and you can inject it into yourself. This drug causes feelings of pleasure.
Cocaine, a substance of notoriety today, is certainly no new drug or menace on the global scene. From 1860, when first synthesized in a German lab from dried Peruvian coca leaf, to around the turn of the century, openly legal and legitimate cocaine stirred a massive boom among scientists and medical men, consumers and enthusiasts of many likes, and international traders and manufacturers, including some of the world’s leading pharmaceutical firms. Yet almost as rapidly, from 1900 to the 1920s, this early medical and commercial fascination with cocaine collapsed, its prestige replaced step by step until the 1960s by the global prohibitionist regimes and