Hemophilia Research Paper

Hemophilia is a disease found in two forms, A and B. They are both caused by lack of a blood clotting factor, eight and nine respectively. I chose this disease because of a podcast I listen to. The podcast was about Grigori Rasputin, a “faith healer” who took care of the youngest child, Alexei Nikolaevich, of Emperor Nicholas II and Empress Alexandra Feodorovna who had Hemophilia. Hemophilia is a disease with a sex-linked pattern of inheritance. It is carried on the X chromosome and is inherited repressively. Males inherit one x chromosome from their mother and a y chromosome from their father. In the case of females, one x from mom and the other from their father. If a son inherits an x chromosome that carries hemophilia from his mother,

The most common treatment is the use of a concentrated Factor Eight product. “The main medication to treat hemophilia A is concentrated FVIII product, called clotting factor or simply factor. Recombinant factor products, which are are developed in a lab through the use of DNA technology, , preclude the use of human-derived pools of donor-sourced plasma.” (Hemophilia A) Using products created from donations of others and new technology, Hemophilia is able to be treated more efficiently. The factor gets injected straight into the veins or through a chest port. These are the safest forms of

Starting with the background, it notes that in the 1940's two concepts were formed. The first was that there are two types, A and B. The second discovery being that blood from one Hemophiliac could normalize blood from another. Shortly after these discoveries the three categories were classified: moderate, mild, and severe. It goes on to state that in some cases, a random mutation may occur causing the disease. This can result in a child with the disease with no family history of it. If a person with the disease is untreated in their early life, lifelong disabilities may