Germline therapy entails altering the genes in egg or sperm cells before they are fertilized. It necessitates the use of in-vitro fertilization when dealing with embryos (“Human Gene Transfer Research,” 2011) and any genetic variations will be passed to future offspring (“Germ Line Therapy,” 2011). Currently, germline therapy is still in its infancy and has only been tested on animals (Darnovsky, 2013). Although this type of therapy decreases the risk of defective genes and thus, has the possibility of preventing congenital diseases, it has elicited substantial ethical controversies.
The major argument raised in favour of germline gene therapy originates from its usefulness. Every year, approximately 7.9 million newborns suffer from a genetic defect (Lobo & Zhaurova, 2008). This therapy, which has a therapeutic impact on not only the person whose gene is altered, but also for future generations, may be the only effective way to address these virtually incurable conditions, such as mitochondrial disease (Mckie, 2014). However, others have argued that because the procedure is unaltera...
Germline gene therapy is where the correct "good" gene is inserted into the germline in place of the defective "bad" gene, and when reproduction occurs the gene will be passed on to the progeny. Inserting the "good" gene into the very early embryo sta ges of development allows for both germline and somatic cells to be corrected. Government has limited the research to only somatic cell gene therapy such as performed in Cystic Fibrosis research.
In this paper, I will argue that genetic therapies should be allowed for diseases and disabilities that cause individuals pain, shorter life spans, and noticeable disadvantages in life. I believe this because everyone deserves to have the most even starting place in life as possible. That is no being should be limited in their life due to diseases and disabilities that can be cured with genetic therapies. I will be basing my argument off the article by “Gene Therapies and the Pursuit of a Better Human” by Sara Goering. One objection to genetic therapies is that removing disabilities and diseases might cause humans to lose sympathy towards others and their fragility (332). However, I do not believe this because there are many other events and conditions in society that spark human compassion and sympathy towards others.
Some people oppose the therapy because the technology used for it could be abused, potentially leading to germline modifications, which are deliberate and purposeful alterations to human DNA that have implications on future children and generations. Germline modifications could lead to the picking of desired traits for babies (as seen in designer babies) and the production of genetically modified people. The creation of people with modified genes could create problems in society as these people could be smarter, more attractive, and stronger than people without modifications. (Kula) Another reason that mitochondrial replacement therapy is opposed is that scientists and doctors do not know how mitochondrial DNA from one female may interact with the nuclear DNA of a mother in an egg, and how this mix of DNA may affect the child. (Weintraub) Three-parent baby girls can pass their mitochondrial DNA onto their future children, which can impact the generations to come. (Kula) Despite its negatives, the therapy should still be permitted so that women with faulty mitochondria can have children free of mitochondrial
Picture a young couple in a waiting room looking through a catalogue together. This catalogue is a little different from what you might expect. In this catalogue, specific traits for babies are being sold to couples to help them create the "perfect baby." This may seem like a bizarre scenario, but it may not be too far off in the future. Designing babies using genetic enhancement is an issue that is gaining more and more attention in the news. This controversial issue, once thought to be only possible in the realm of science-fiction, is causing people to discuss the moral issues surrounding genetic enhancement and germ line engineering. Though genetic research can prove beneficial to learning how to prevent hereditary diseases, the genetic enhancement of human embryos is unethical when used to create "designer babies" with enhanced appearance, athletic ability, and intelligence.
In the modern world humans have been able to design and create nearly anything, most to aid us in our daily lives and improve our standard of living. It is only inevitable that eventually humans would take our superior knowledge and skill to manipulate life itself and change our genome to produce a healthier and even more superior human standard of life. In recent years discussion about gene therapy has changed into a promising possibility to treat many of our common human diseases and disorders. Although gene therapy might be the answer to many problems, it has been met with a number of logistical and ethical hardships. With the prospect of being a treatment for inherited genetic disorders, cancers, and viral infections, gene therapy seems like the logical fix-it-all bandage that many people would benefit from.
Despite being magical of gene therapy, it is high-risk. Few people got benefits from it, and it has a low rate of success. Prior to the human trial, Batshaw and Wilson had done experiment on animals to ensure the safety. Over 20 experiments have been done on mice but only 12 of them survived at last (Sophia, M. and Kolehmainen, J.D., 2000). More seriously, complicating diseases, which can be more dangerous than genetic diseases, might set in during the treatment period. In December 200...
People should not have access to genetically altering their children because of people’s views on God and their faith, the ethics involving humans, and the possible dangers in tampering with human genes. Although it is many parent’s dream to have the perfect child, or to create a child just the way they want, parents need to realize the reality in genetic engineering. Sometimes a dream should stay a figment of one’s imagination, so reality can go in without the chance of harming an innocent child’s life.
Gene therapy is a relatively simple process. First, the mutated gene at fault for the cause of the condition being treated must be identified. Second, the site of the unhealthy cells in the human has to be found. Then, a health...
Every year, the rate of mortality increasing because most diseases may lead to death if not treated early. One of the methods that can be used to cure some diseases is by using the treatment known as gene therapy. Based on Pruitt’s (2008) study, numbers of inherited and acquired diseases were reduced since gene therapy has the ability to provide new treatments to cure them. According to Shi and Zou (2008), gene therapy is defined as expression of protein or interrupts the synthesis of protein in cell by transferring the genetic material into a host in order to treat or prevent a disease. Besides that, Kelly (2007) stated that an “abnormal” hereditary disease-causing gene in an individual’s cells and tissues is treated and used gene therapy by to replace them with a “normal” gene. Around 1970’s, idea to use “genes” as “drugs” for human therapy was originally from United States (Giacca, 2010). Moreover, there are some objectives in using the gene therapy as a treatment. First, gene therapy is used to cure or slow the progression of disease by introducing the genetic material into target cells and next objective is to aim at the direct correction of endogenous genetic defects by delivered some additional copies of a gene (Pruitt, 2008; Giacca, 2010). Furthermore, Yadav and Tyagi (2008) found that there are two types of gene therapy which are germline gene therapy and somatic cell therapy. As stated by Shi and Zou (2008), therapy that involved modification of any cells in a patient’s body is called as somatic cell gene therapy while germ line gene therapy is therapy that involved modifying of human eggs or sperms that pass genes on to future generations. Other than that, animal tissue culture is used to test the effective...
[7] Stock, G., and Campbell, J.. "Engineering the Human Germline: an Exploration of the Science and Ethics of Altering the Genes We Pass to Our Children, New York; Oxford University Press, 2000. back
Test tube babies have long been stigmatized by society as the unnatural results of scientific dabbling. The words `test tube baby' have been used by school children as an insult, and many adults have seen an artificial means of giving birth as something perhaps only necessary for a lesbian woman, or a luxury item only available to the elite few. The reality is that assisted reproductive technologies (ART) have been helping infertile couples have children since 1978.1 The methods of in vitro fertilization, it's variants, and the other ART procedures are ways for persons that would otherwise have no hope of conception to conceive and, in a rapidly growing percentage of cases, give birth to healthy babies. As the technology has developed, the quality and range of assistance has developed as well. At present, the means of assisted reproduction and the capabilities of these procedures has grown at a somewhat dizzying pace. However, thought to the repercussions of the applications of ART are being disregarded to some extent while the public's knowledge and the understanding of embryologists and geneticists surges forward. It is possible given consideration to things such as the morality of these techniques, the unexplored alternative uses of these procedures, and the potential impact they posses that further development is unnecessary and possibly dangerous.
Since its inception, gene therapy has captured the attention of the public and ethics disciplines as a therapeutic application of human genetic engineering. The latter, in particular, has lead to concerns about germline modification and questions about the distinction between therapy and enhancement. The development of the gene therapy field and its progress to the clinic has not been without controversy. Although initially considered as a promising approach for treating the genetic of disease, the field has attracted disappointment for failing to fulfil its potential. With the resolution of many of the barriers that restricted the progress of gene therapy and increasing reports of clinical success, it is now generally recognised that earlier expectations may have been premature.
Pray, Leslie A., Ph.D. “Embryo Screening and the Ethics of Human Genetic Engineering.” Nature.com. Nature Publishing Group, 2008. Web. The Web.
Gene therapy gives patients who born with diseases that are incurable to traditional medicine a permanent cure. If patients received germ-line therapy, which involves replacing disordered genes in sperms or eggs, their offspring would also have correct gene orders. The positive effect would influence the whole family.
There are different ways and reasons why people wish to change the genes in their cells; the two categories split into “somatic and germline genetic engineering”. When a scientist uses “somatic genetic engineering” -the sex cells-- eggs and sperms are not affected; a specific gene code is changed and the genes do not pass down to the next generation. The other genetic engineering used is “germline” which, in contrast to somatic engineering, affects the eggs and sperms. When germline genetic engineering is used, the genes will be passed down to the next generation, affecting the physical and genetic traits. The debate rises and people question people’s free will. Bioethics is the formal and recognized term that describes the advantages and disadvantages that genetic enginee...